Recent Searches

Share this Post

Share on facebook
Share on twitter
Share on linkedin
Share on email

Home
Humanized Mice
Case Study - Bispecific CRS Data Set

Case Study - Bispecific CRS Data Set

Published Date October 6, 2020

Download PDF

Previous Flipbook

Case Study: CRS and Efficacy using a BCMAxCD3 Bispecific Antibody
Next Flipbook

Case Study: PK/PD, Safety, and Efficacy Platforms

Other content in this Stream

16 days ago
JAX Humanized Mice PubCast: Mast cells & Anti-PD-1 Therapy (Apr. 3, 2024)

Join us as we discuss a collaborative effort between academia and a biopharmaceutical company, which utilized humanized mice to explore the role of mast cells in the melanoma tumor microenvironment.

Watch Video
about 1 month ago
JAX Humanized Mice PubCast: HIV-1 in Humanized Mice (Mar. 14, 2024)

In this PubCast, we discuss a study from Yale University that employed humanized PBMC-NSG mice to model HIV and test the efficacy of two novel long-acting antiretroviral delivery systems. Resource

Watch Video
2 months ago
Comparing Immune-Humanized Mouse Platforms for Preclinical Applications

February 20, 2024 - During this presentation, we compare strategies for immune humanization of NSG variants to support translatable preclinical immunology and oncology research.

Watch Video
3 months ago
Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research

January 16, 2024 - In this webinar, we discuss the most widely used immunodeficient mouse models and essential considerations for selecting the most appropriate model.

Watch Video
5 months ago
Translatable Efficacy & Safety Testing of mAb, Bispecific, & CAR T Therapies

During this webinar, we discuss preclinical data showcasing efficacy and safety testing of immunotherapies in immune humanized mouse models.

Watch Video
6 months ago
De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)

In this webinar, we discuss the humanized FcRn platform, an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules.

Watch Video
6 months ago
New Immune-humanized Models Support More Diverse Human Immune Cell Lineages

In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.

Watch Video
4 months ago
Rapid In Vivo Evaluation of Immuno-Modulatory Therapies Using Hu-PBMC NSG™ Mice

Learn about Hu-PBMC NSG models that can be used to test the efficacy of human T cell immunomodulatory therapeutics for graft-versus-host disease (GvHD), autoimmune disorders, and cancer.

Watch Video
over 1 year ago
Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics

Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.

Watch Video
over 1 year ago
DROSHA but not DICER is Required for Human Haematopoietic Stem Cell Function

Using lentiviral shRNA constructs, this presentation demonstrates that DROSHA, but not DICER, is required for the differentiation of human HSCs after engraftment into immunodeficient NSG-SGM3 mice.

Watch Video
almost 2 years ago
Novel Humanized Mouse Model for Assessment of Human Allogeneic Responses in Organ Transplantation

Ashwin Ajith Ph.D., a postdoctoral fellow at the Georgia Cancer Center, Augusta University, discusses using humanized mouse models to study alloimmune responsiveness between donor and recipients.

Watch Video
almost 2 years ago
Modeling Human Melanoma To Understand And Treat Resistance To Immunotherapy

Meenard Herlyn, DVM, DSc discusses the development of a variety of 3D models, from human skin equivalents to organoids, mimicking cellular interactions in normal and malignant tissues.

Watch Video
almost 2 years ago
Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer

The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm

Watch Video
almost 2 years ago
JAX Tech Episode 55: Let’s Talk of Mice and Monkeys (May 17, 2022)

This discussion focuses on preclinical efficacy and safety testing for novel antibody-based therapeutics.

Watch Video
about 2 years ago
How To Make Your New NSG Variant in a Fraction of the Time

CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...

Learn More
about 2 years ago
A Novel Clinically Relevant Graft-Versus-Leukemia Model in Humanized Mice

Hong Zheng, M.D., Ph.D., Associate Professor of Medicine at Penn State Cancer Institute, Penn State University College of Medicine joined us to lead a discussion on a new immune-humanized mouse model.

Watch Video
about 2 years ago
Achieving Relevant Preclinical Characterization of CAR T Cell Therapies

This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.

Read Flipbook
about 2 years ago
2022 AACR POSTER: Enhanced Development Of Functional Human Innate Immune Cells In A Novel FLT3NullNSG Mouse Strain Expressing Human FLT3L

Read Flipbook
7 months ago
A MHC Class I & II Deficient Platform Humanized with PBMCs

JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.

Read Flipbook
about 2 years ago
CRS Studies for CAR T Cell Therapy

Review JAX’s CRS evaluation capabilities and see how a CRS study can help move your CAR T therapeutic into the clinic faster, safer, and more confidently.

Read Flipbook

Return to Home