A New Way to Study Cytokine Release Syndrome
In vivo CRS assays have the potential to simultaneously derisk and accelerate the process of bringing successful therapies to the patients who need them most.
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PREDiCT: Tumour Models London
Explore the latest JAX resources on immune-humanized mice, safety, and toxicity.
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Testing the Efficacy of Immuno-Modulatory Antibodies in Humanized Mice
Aaron Rose, Ph.D., Senior Study Director, In Vivo Services, The Jackson Laboratory speaks about testing the efficacy of immunomodulatory antibodies in humanized mice.
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The Humanized FcRn Platform: An Essential Tool for Preclinical PK Assessment of Therapeutic Antibody Candidates
Greg Christianson, Study Director, In Vivo Services, The Jackson Laboratory speaks about the use of human FcRn transgenic mouse models to select antibody therapeutic candidates with optimum pharmacoki
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GvHD Efficacy Study Fact Sheet
An example of study information provided when conducting a GvHD study with the Jackson Laboratory. This example shows Bispecific Antibodies in comparison with Abatacept.
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Use of FcRn Transgenic mice for drug discovery of therapeutic antibodies with Roche's Michael Otteneder, PhD
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JAX Guide: Assessing Antibody Pharmacokinetics Using the JAX FcRn Platform
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IgG production in humanized mice
Sebastian Theobald, Hannover Medical School Title: Modeling human cytomegalovirus infections in humanized mice for preclinical development of novel cellular and antibody-based therapies
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Why humanized mice?
You may have noticed that the latest biomedical breakthroughs are utilizing more and more humanized mice. But, what is a humanized mouse and why would scientists want to utilize this type of...
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CD34+ Hematopoietic Stem Cell Humanized Mice: The Basics
Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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