Open Access to an Improved Preclinical Mouse Model of Familial Alzheimer’s Disease
As part of the MODEL-AD consortium, JAX has generated a more clinically relevant mouse model of familial Alzheimer's Disease for preclinical testing. This APPSAA knock-in model (strain #034711) recapitulates clinical amyloid plaque pathology in vivo without disturbing intrinsic gene expression. There are no licenses or restrictions on commercial use.