Preclinical Neurobiology Services Booklet
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Neurobiology
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Leveraging Biomarkers to Track ALS Progression in Mouse Models for Drug Discovery
Watch this webinar to learn how JAX is leveraging biomarkers—measurable indicators of disease presence, progression, and treatment response—in ALS mouse models.
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Overcoming Challenges in Preclinical Gene Therapy Testing for Neurological Diseases
Watch this webinar to learn how JAX leverages validated models of neurodegenerative and neurodevelopmental disease to evaluate biodistribution, efficacy, and target engagement.
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JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice
In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.
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Digital Measures in an Animal Model of Neuromotor Disease
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Emerging Models for Alzheimer's Disease
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Optimize Your Studies: Key Considerations with Mouse Neurological Models
During this webinar, we discuss best practices for model selection, study design, and experimental reproducibility.
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Selecting and Using Mouse Models in Neurodevelopmental Drug Discovery
Join the JAX In Vivo Services team as they share insights from extensive neurobiology drug discovery studies conducted for both academic and commercial clients.
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Upcoming Release of iPSC Lines
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JAX Tech Talk Episode 68: Let’s Talk iPSC Disease Models as a Tool in Drug Discovery (Nov. 7, 2023)
During this JAX Tech Talk, Dr. Steven Rodriguez, Lab Head of the Rare & Neurological Diseases Therapeutic Area at Sanofi, discusses how his group uses iPSC models to understand disease biology.
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The Complexity of Rare Disease
Learn about the complexity of rare disease and the unique difficulty it presents to patients and families by exploring the patient journey—from diagnosis to research to drug development.
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Neurofilament Light Chain Tech Sheet
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Exploring Rare Disease Through Translational Research
Learn how mouse models help researchers disentangle the complexity of rare disease and help drive preclinical drug development.
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JAX Tech Talk Episode 62: Let’s Talk About the Uncommon: Rare Diseases (Feb. 7, 2023)
February 7, 2023 - In this episode, we discuss the importance of studying rare diseases and the critical preclinical steps leading to diagnosis and treatment development.
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2022 SfN 370.12 Characterization of Aging X Genetic X Environment as Precision Disease Models For Evaluation of Therapeutic Interventions Fo
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Preclinical Assessment of Investigational Gene Therapy Products for Neuroscience
Learn how to overcome the challenges to develop gene therapies, specifically for neurodevelopmental and neurodegenerative diseases.
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C9Orf72 Tech Spec Sheet
The Jackson Laboratory is the exclusive service provider for robust, reliable, reproducible gene therapy, efficacy, and safety studies in the C9orf72 mouse model, the most common form of familial ALS.
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JAX Tech Talk Episode 59: Let’s Talk iPSCs and Their Value in Tackling Neurodegenerative Diseases (Sep. 20, 2022)
Dr. Mark Cookson talks about the unique aspects of the collection of human isogenic iPSC lines and how it can benefit the wider scientific community in their shared quest to understand and fight ADRD.
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In Vivo Drug Discovery Platforms for Amyotrophic Lateral Sclerosis
Watch this webinar to review phenotypic characteristics, considerations for selecting therapeutically relevant ALS models, and more!
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ES Cell Microinjection: FAQ
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