Modeling Differential Patient Responses to B Cell Elimination with S15-DKO
Learn how S15-DKO mice can be used to evaluate tri-specific killer engagers (TriKEs) in the settings of lupus and B cell lymphoma.
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Immuno-Oncology
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Mouse Models that Bridge the Gap in Immunotherapy Discovery
Immunotherapy is an effective way to fight cancer using the body’s own immune system. From basic research to drug discovery, in vivo modeling has become the cornerstone of immunotherapy...
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What is a Humanized Mouse? FAQs about models for immunology, immuno-oncology, and pharmacokinetics.
What is a humanized mouse model?A humanized mouse refers to a mouse that carries some aspect(s) of human biology. For instance, “humanized” could refer to a mouse expressing a human gene...
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An Advanced PBMC-Humanized NSG-S15-DKO Mouse Model for Comprehensive Evaluation of Immunotherapeutics
What You'll Learn:PBMC models enable in vivo human immune system studiesDelayed GvHD supports longer, more flexible study windowsNSG-S15-DKO shows:Enhanced multi-lineage engraftment (T, NK,...
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S15-DKO: New Platform for Engraftment of Human PBMC Supporting Multilineage Immune Cells, Low GvHD
Learn about the S15‑DKO strain (NSG-NSG‑MHC I/II DKO × NSG‑SGM3‑IL15), which supports broader human immune cell engraftment (T, B/plasma, NK, cDC, macrophages, γδ T cells) without acute xGvHD.
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New JAX NSG portfolio strains support development of human NK cells in oncology models
IntroductionNatural killer (NK) cells occupy an intriguing niche between adaptive and innate immunity. Like cytotoxic T lymphocytes, they can recognize and kill infected or malignant cells and...
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Exploring Biologics to Drive NK Cell Immunotherapy in Mouse Models of Human Cancer
Learn how mouse models, using different formats of human natural killer (NK) cells and human cancer cells, can be leveraged to evaluate the efficacy of biologics to amplify tumor control.
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Guide to Choosing the Right Cancer Research Model
This webinar provides a comprehensive, scientifically grounded overview of the diverse oncology model platforms available from The Jackson Laboratory
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Immune Cell Humanized Mice: CD34+ Hematopoietic Stem Cell Engrafted Mice
Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...
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Immune Cell Humanized Mouse Models: PBMC Engrafted Mice
Charu Gupta, Ph.D., Senior Technical Information ScientistKey PBMC Takeaways:Rapid engraftment: PBMCs engraft in 2-3 days with mature, human-protein expressing T cells.Human-relevant modeling:...
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De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)
In this webinar, we discuss the humanized FcRn platform, an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules.
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HuPK™: A Humanized Platform for therapeutic antibody PK evaluation
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PEGS EU 2023 - Predicting the Clinical PK of Candidate Therapeutic Antibodies
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Immunomodulatory Profile
Bispecifics and CAR-T sequences
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Of Mice and Men - FcRn Biology and it's Implications in a Therapeutic Perspective
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Humanized Mice: FcRn Biology
Simone Mester, PhD, Authera Biotech, speaking at The Jackson Laboratory EU Symposium. Of Mice and Men - FcRn biology and its implications in a therapeutic perspective.
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Humanized Mice: Hematopoietic Stem Cells and Antibody-Mediated Depletion
Frank Lehmann, PhD, Cimeio Therapeutics, speaking at The Jackson Laboratory EU Symposium. Molecular shielding protects hematopoietic stem cells from antibody-mediated depletion.
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Humanized Mice: Next Generation Mesenchymal Cell Therapy: From CAR-T to COVID-19
Tomer Bronshtein, PhD speaking at The Jackson Laboratory EU Symposium. Preclinical to clinical development of next-generation mesenchymal cell therapy: from CAR-T induced CRS in humanized models to re
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CRS Highlights for EU Symposium
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Evidence-Based Selection of the Starting Dose in First-in-Human Clinical Trials Using Humanized Mouse Models
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