The Jackson Laboratory Resource Center for Oncology Research

Exploring Biologics to Drive NK Cell Immunotherapy in Mouse Models of Human Cancer

Learn how mouse models, using different formats of human natural killer (NK) cells and human cancer cells, can be leveraged to evaluate the efficacy of biologics to amplify tumor control.

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about 1 month ago

The Hallmarks of Cancer – a Celebration of the 2026 Edition

Introduction: The History of “The Hallmarks of Cancer”Cancer researchers around the world are familiar with the landmark publication “The Hallmarks of Cancer,” initially set out by Hanahan and...

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2 months ago

Immune Cell Humanized Mice: CD34+ Hematopoietic Stem Cell Engrafted Mice

Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...

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over 2 years ago

SITC 2023 Comparison of Blinatumomab and Biosimilar CD19xCD3 BiTE responses in PBMC-Humanized Mice Used as a Preclinical Lymphoma Mouse Mode

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over 2 years ago

2023 AALAS P403 Comparing tumor erosion rate following P16MC38 subcutaneous (SC) vs. mammary fat pad (MFP) injections

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over 2 years ago

2023 AALAS P402 Evaluating sub-renal capsule cavity tumor growth in immunodeficient NSG-MHC I/II double knock-out mice

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9 months ago

Immunomodulatory Profile

Bispecifics and CAR-T sequences

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almost 3 years ago

The Next Generation of Humanized Mice for Translational Research - Dr. Michael Brehm

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about 3 years ago

2023 AACR Mouse models of cancer available from The Jackson Laboratory

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over 3 years ago

In vivo Preclinical Efficacy & Safety of CAR-T, -NK, and -Myeloid Based Therapies

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9 months ago

JAX Tech Talk Episode 60: Let's talk JAXBoy, a new and improved CD45.1 C57BL/6 mouse (Nov. 8, 2022)

November 8, 2022 - Congenic markers are a key tool for tracking cells in adoptive transfer and competitive bone marrow transplant experiments. But did you know that traditional strains harbor an artif

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over 3 years ago

2022 SITC 1427 Comparative analysis of human immune subsets and Rituximab antitumor response across multiple NSG strains engrafted with huma

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over 3 years ago

2022 SITC 1258 PBMC humanized mouse model with clinical relevance in assessing the safety profile of 4-1BB agonists utomilumab and urelumab

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over 3 years ago

Preclinical Assessment of Engineered Immunoglobulins in Immune Humanized Mice

Presented by Brian Soper, Ph.D. - Senior Scientific Engagement Manager, The Jackson Laboratory

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over 3 years ago

The Application of Humanized Mouse Models to Study LILRB-Mediated Regulation of Myeloid Cells

Presented by Ali Roghanian, Ph.D., Lecturer (Assistant Professor) in Cancer Immunology & Immunotherapy, University of Southampton

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over 3 years ago

Patient management after genomic testing

Provides an overview of the option to receive medically actionable results unrelated to the presenting condition

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9 months ago

Modeling Human Melanoma To Understand And Treat Resistance To Immunotherapy

Meenard Herlyn, DVM, DSc discusses the development of a variety of 3D models, from human skin equivalents to organoids, mimicking cellular interactions in normal and malignant tissues.

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Cancer Susceptibility Genes

Lists genes that are associated with hereditary cancer and should be considered for referral when identified on a tumor test report.

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Testing to Identify Genomic Variants Related to Cancer

Defines and compares benefits and limitations of type of testing: somatic, paired somatic/germline and concurrent somatic + germline.

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Benefits of Exome Testing

Outlines advantages of exome testing across various clinical specialties

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