Improved humanization of peripheral blood mononuclear cells in NSG-SGM3xIL15xDKO (S15-DKO) over that of NSG-MHC I/II DKO mice for immune-onc
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Immune Humanized Mice
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Inducing memory humoral responses using multiple vaccines in PBMC humanized mice
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In vivo Lentiviral CAR-T Gene Delivery Demonstrates High Specificity and Potent anti-Tumor Activity in a Humanized B Cell Lymphoma Model
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In Vivo Evaluation of Autologous Anti-BCMA CAR-T Therapy in PBMC-humanized S15-DKO Mice Reveals Donor-specific Immune Responses
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A novel NSG-SGM3xIL15xDKO-based PBMC humanized mouse model to evaluate efficacy and cytokine release of immunotherapies
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Robust Engraftment of Human γδ T Cells in Humanized NSG-SGM3-IL-15 x MHC I/II Double Knockout Mice For the Evaluation of γδ T Cell-based The
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Next-Gen Immune-Humanized Models for Antibody Drug Development
Dr. Brian Soper, Senior Scientific Engagement Manager at The Jackson Laboratory, presents Next-Gen Immune-Humanized Models for Antibody Drug Development
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Use of Humanized Mouse Models in Drug Development - Voot Yin
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Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models
Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.
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JAX Presentation - Use of Humanized Mouse Models in Drug Development - Brian Soper, Ph.D.
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Translatable Efficacy & Safety Testing of mAb, Bispecific, & CAR T Therapies
During this webinar, we discuss preclinical data showcasing efficacy and safety testing of immunotherapies in immune humanized mouse models.
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SITC 2023 Comparison of Blinatumomab and Biosimilar CD19xCD3 BiTE responses in PBMC-Humanized Mice Used as a Preclinical Lymphoma Mouse Mode
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SITC 2023 PBMC Humanized Mouse Model with Clinical Relevance in Assessing the Safety Profile of 4-1BB Agonist, Urelumab, in 5 Donors
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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages
In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.
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PEGS EU 2023 - Translational Humanized Models for Immunotherapy Drug Development
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CD34+ Hu-NSG-SGM3-IL15 Tech Sheet
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Evaluation of Safety and Efficacy of Antibody Therapies in Humanized Mice_Dr. James Keck
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A Novel PBMC Humanized Mouse Model_Dr. James Keck
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A humanized mouse model to study activity of cytotoxic and immunomodulatory human IgG - Dr. Anja Lux
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The Application of Humanized Mice in Manipulation of Myeloid Cells - Dr. Ali Roghanian
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