Learn about new technologies and discoveries focused on precise and personalized treatments for patients.
What You'll Learn:PBMC models enable in vivo human immune system studiesDelayed GvHD supports longer, more flexible study windowsNSG-S15-DKO shows:Enhanced multi-lineage engraftment (T, NK,...
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IntroductionNatural killer (NK) cells occupy an intriguing niche between adaptive and innate immunity. Like cytotoxic T lymphocytes, they can recognize and kill infected or malignant cells and...
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Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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In a previous post I discussed breeding Cre/lox mice to generate tissue-specific and inducible conditional knockout mouse strains. I would now like to continue the discussion of breeding Cre/lox...
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Many commercial and academic researchers have access to a vivarium and have not seriously considered using outside resources. Rising model complexity, tighter budgets, and shrinking vivarium...
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Introduction: The History of “Hallmarks” in Biological ResearchLife science researchers worldwide are familiar with the publication series “The Hallmarks of Cancer”, initially laid out by Hanahan...
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Researchers have long relied on single measures and univariate analytical approaches to evaluate animal health, physiology, and behavior as proxies for complex biological states. While clearly...
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Animal physiological and behavioral research is subject to many confounding influences that can be difficult to control, potentially compromising experimental findings. Without proper experimental...
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Science depends on reproducibility, yet getting consistent results in biological systems can often be challenging. The inherent complexity of these systems makes it difficult to observe...
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Are you experiencing suboptimal breeding performance in your mouse colonies? Navigating mouse husbandry requires specialized knowledge. In this article we offer expert, JAX-approved guidance, in...
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Introduction: The History of “The Hallmarks of Cancer”Cancer researchers around the world are familiar with the landmark publication “The Hallmarks of Cancer,” initially set out by Hanahan and...
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Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...
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Charu Gupta, Ph.D., Senior Technical Information ScientistKey PBMC Takeaways:Rapid engraftment: PBMCs engraft in 2-3 days with mature, human-protein expressing T cells.Human-relevant modeling:...
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The NntC57BL/6J mutation in the nicotinamide (NAD) nucleotide transhydrogenase (Nnt) gene is found exclusively in B6/J-derived mice and has not been detected in any other B6 substrains, including...
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Cryopreservation is a powerful tool for colony management, protecting strains from loss while ensuring they remain available upon demand and at the scale needed (see IVF Speed Expansion...
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As gene therapy continues to revolutionize modern medicine, the demand for reliable, translational, and ethically sound preclinical models has never been higher. In vivo gene delivery systems,...
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At The Jackson Laboratory (JAX), cryopreservation is a cornerstone of our research and colony management strategy. With decades of experience, we have optimized our cryopreservation protocols and...
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Sam Eck, Ph.D. - Technical Information ScientistIntroduction: The Historical Context of Sex Bias In 1993, the NIH issued the Revitalization Act which for the first time required the inclusion of...
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The Jackson Laboratory Contributes to Landmark Consensus Standards for Metabolic ResearchScientific progress depends on standardization. Just as consensus standards in genomics and metabolics...
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As the industry leader in laboratory mouse breeding, care, and colony management, we know how complex—and fragile—animal research can be. Maintaining animal colonies and developing experimental...
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