The term “humanized” mouse can mean many things to many people, but we’ll define it as a mouse that harbors engrafted human tissue or cells, such as immune cells. Here are some helpful tips.
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You may have noticed that the latest biomedical breakthroughs are utilizing more and more humanized mice. But, what is a humanized mouse and why would scientists want to utilize this type of...
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Under certain circumstances in patients, the human immune system can spin out of control and become highly toxic, resulting in cytokine release syndrome (CRS). CRS has been observed in certain...
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When people think of innovation, often times they think of new products like iPhones and companies like SpaceX. But innovation spans far beyond what one may typically think of and can be applied...
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Beta-amyloid peptid. The amyloid precursor protein being cleaved by gamma and beta secretases and releasing the amyloid beta peptide, which can accumulate to amyloid plaques, one of the main...
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How to address secondary findings from genomic testing Consider this scenario: Jayne is 50 years old and has experienced progressing neurological symptoms over the past two years with no...
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Immunodeficient mice are invaluable tools for immunology, infectious disease, oncology, hematopoietic, and regenerative medicine studies. They can serve as hosts for engraftment of mouse tumor...
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Explore the options available to set you up for success and get back in the race as quickly as possible.
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Julia is a woman in her early 20s establishing care in your practice. During the course of your conversation, she tells you that she recently did an at-home ancestry test and was surprised when...
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Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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All that glitters… Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor T-cells, promoting their own...
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The COVID-19 pandemic is forcing many program directors and instructors to adjust their curriculum from face to face to online formats. Making that transition can be difficult especially if you...
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Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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An interview with Anshul Kundaje Machine learning and deep learning in particular have a growing influence on everything from how we shop to how we drive—or are driven by self-driving cars....
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What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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Studying cancer cell development, including signaling pathways and other types of cell-cell communications between immune cells and tumors, is critical to generating and evaluating...
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Camille is a 32 year-old woman at 10 weeks gestation in her first pregnancy. At her first prenatal appointment, Camille elects cell-free DNA screening for aneuploidy. She is not concerned about...
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Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...
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The mouse is arguably the most widely used mammalian model in biomedical research. Their relatively small size, and both genetic and physiological similarity to humans, make mice a model organism...
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Breast cancer risk assessment is increasingly included in primary care. As a rule of thumb, approximately 5-10% of individuals with a breast cancer diagnosis will be found to carry a pathogenic...
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