As colleges and universities, research institutes and other organizations continue to create more high-quality online courses, these digital badges are becoming a common way for successful...
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But wait, didn’t the Human Genome Project accomplish that feat about 20 years ago? The simple answer is no, it did not. The first “complete” human genome sequence was actually complete only in...
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The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...
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CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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Introduction Since the first chimeric antigen receptor (CAR) T cell therapy received FDA approval in 2017, this promising immunotherapy modality has only continued to gather momentum. Existing...
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It’s been long recognized that aging is the single biggest risk factor for cancer and that age impacts treatment response. Research is urgently needed to develop a mechanistic understanding of the...
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Just last week, the Food and Drug Administration (FDA) published recommendations to drug developers and researchers urging them to consider alternatives to non-human primates (NHPs) in general...
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Although many mammals have immune systems that share important characteristics with humans, certain immune cell types and phenomena are unique to us. As a result, it has been difficult to design...
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Dr. Kimathi is a medical oncologist in a community setting where she sees patients with a variety of cancer diagnoses. Recently, she had several patients with toxicities to different treatments,...
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Our immune system is incredibly complex and powerful—sometimes almost too powerful. Occasionally, it responds to a disease or drug with an inflammatory overreaction known as cytokine release...
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Cultural competency is defined as the ability to understand, appreciate and interact with people from a culture or belief systems different from one’s own (American Psychological Society 2015)....
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This scenario is more complicated than it may seem. With genomic tumor testing, a negative result is not always definitive. In some cases a genomic variant can be present but not detected by the...
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With November designated as Family Health History month, clinicians are sure to have seen lots of messaging encouraging their patients to discuss family health history around the holiday table....
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Frustrated about lack of actionable results in genetic testing Donna is a 60-year-old Black woman with a personal history of breast cancer, diagnosed at age 49. Her oncologist recommended she...
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This user guide is designed to introduce you to the core concepts of genetic diversity, present diversity models, and their key features.
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The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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If you’ve been following our blog or participating in our courses, you’ll know that there are many hereditary cancer syndromes that increase adults’ lifetime cancer risks. Often, adults undergoing...
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Like one in five Americans, I wear a watch that also tracks several health-related statistics through the day. It tells me how well I slept, how many steps I took, how high my heart rate got...
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Aged C57BL/6J mice represent a new dietary model for nonalcoholic steatohepatitis (NASH) that accounts for the known risk factor of age in the human disease.
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Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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