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Many commercial and academic researchers have access to a vivarium and have not seriously considered using outside resources. Rising model complexity, tighter budgets, and shrinking vivarium...
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Introduction: The History of “Hallmarks” in Biological ResearchLife science researchers worldwide are familiar with the publication series “The Hallmarks of Cancer”, initially laid out by Hanahan...
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Researchers have long relied on single measures and univariate analytical approaches to evaluate animal health, physiology, and behavior as proxies for complex biological states. While clearly...
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Animal physiological and behavioral research is subject to many confounding influences that can be difficult to control, potentially compromising experimental findings. Without proper experimental...
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Science depends on reproducibility, yet getting consistent results in biological systems can often be challenging. The inherent complexity of these systems makes it difficult to observe...
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Are you experiencing suboptimal breeding performance in your mouse colonies? Navigating mouse husbandry requires specialized knowledge. In this article we offer expert, JAX-approved guidance, in...
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Introduction: The History of “The Hallmarks of Cancer”Cancer researchers around the world are familiar with the landmark publication “The Hallmarks of Cancer,” initially set out by Hanahan and...
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Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...
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Charu Gupta, Ph.D., Senior Technical Information ScientistKey PBMC Takeaways:Rapid engraftment: PBMCs engraft in 2-3 days with mature, human-protein expressing T cells.Human-relevant modeling:...
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Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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The NntC57BL/6J mutation in the nicotinamide (NAD) nucleotide transhydrogenase (Nnt) gene is found exclusively in B6/J-derived mice and has not been detected in any other B6 substrains, including...
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Cryopreservation is a powerful tool for colony management, protecting strains from loss while ensuring they remain available upon demand and at the scale needed (see IVF Speed Expansion...
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As gene therapy continues to revolutionize modern medicine, the demand for reliable, translational, and ethically sound preclinical models has never been higher. In vivo gene delivery systems,...
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At The Jackson Laboratory (JAX), cryopreservation is a cornerstone of our research and colony management strategy. With decades of experience, we have optimized our cryopreservation protocols and...
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Sam Eck, Ph.D. - Technical Information ScientistIntroduction: The Historical Context of Sex Bias In 1993, the NIH issued the Revitalization Act which for the first time required the inclusion of...
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The Jackson Laboratory Contributes to Landmark Consensus Standards for Metabolic ResearchScientific progress depends on standardization. Just as consensus standards in genomics and metabolics...
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As the industry leader in laboratory mouse breeding, care, and colony management, we know how complex—and fragile—animal research can be. Maintaining animal colonies and developing experimental...
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Induced pluripotent stem cells (iPSCs) have become a cornerstone of modern biomedical research, offering unprecedented opportunities to model human development, investigate disease mechanisms, and...
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Imagine, after years of research, you and your team discover an unfortunate mutation in the mouse model you have been using. The work you have dedicated yourself to for so long must be discarded,...
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In the field of stem cell research, the quest to define a “reference” induced pluripotent stem cell (iPSC) line is ongoing and nuanced. As we deepen our understanding of human biology, one thing...
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