The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...
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CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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Introduction Since the first chimeric antigen receptor (CAR) T cell therapy received FDA approval in 2017, this promising immunotherapy modality has only continued to gather momentum. Existing CAR...
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It’s been long recognized that aging is the single biggest risk factor for cancer and that age impacts treatment response. Research is urgently needed to develop a mechanistic understanding of the...
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Just last week, the Food and Drug Administration (FDA) published recommendations to drug developers and researchers urging them to consider alternatives to non-human primates (NHPs) in general...
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Although many mammals have immune systems that share important characteristics with humans, certain immune cell types and phenomena are unique to us. As a result, it has been difficult to design...
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Dr. Kimathi is a medical oncologist in a community setting where she sees patients with a variety of cancer diagnoses. Recently, she had several patients with toxicities to different treatments,...
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Our immune system is incredibly complex and powerful—sometimes almost too powerful. Occasionally, it responds to a disease or drug with an inflammatory overreaction known as cytokine release...
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Cultural competency is defined as the ability to understand, appreciate and interact with people from a culture or belief systems different from one’s own (American Psychological Society 2015)....
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This scenario is more complicated than it may seem. With genomic tumor testing, a negative result is not always definitive. In some cases a genomic variant can be present but not detected by the...
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With November designated as Family Health History month, clinicians are sure to have seen lots of messaging encouraging their patients to discuss family health history around the holiday table....
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Frustrated about lack of actionable results in genetic testing Donna is a 60-year-old Black woman with a personal history of breast cancer, diagnosed at age 49. Her oncologist recommended she...
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This user guide is designed to introduce you to the core concepts of genetic diversity, present diversity models, and their key features.
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The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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If you’ve been following our blog or participating in our courses (learn.education.jax.org), you’ll know that there are many hereditary cancer syndromes that increase adults’ lifetime cancer...
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Like one in five Americans, I wear a watch that also tracks several health-related statistics through the day. It tells me how well I slept, how many steps I took, how high my heart rate got...
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Aged C57BL/6J mice represent a new dietary model for nonalcoholic steatohepatitis (NASH) that accounts for the known risk factor of age in the human disease.
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Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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Dr. Yang is a community oncologist who sees patients with a range of cancer types and indications. She often recommends tumor biomarker testing, or genomic tumor testing, for patients with...
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But what about other organisms? Plants have proven to be particularly thorny sequencing subjects, with many containing massive, highly repetitive genomes. The largest yet identified is from Paris...
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