Updates in BRCA testing for People of Ashkenazi Jewish Ancestry

Julia is a woman in her early 20s establishing care in your practice. During the course of your conversation, she tells you that she recently did an at-home ancestry test and was surprised when...

CD34+ Hematopoietic Stem Cell Humanized Mice: The Basics

Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...

The ABC’s of CAR T Cell Therapies

All that glitters… Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor T-cells, promoting their own...

JAX CEO Dr. Edison Liu in the Portland Press Herald

JAX CEO Dr. Edison Liu Interviewed on WCSH

JAX President Edison Liu answers questions about the spread of COVID-19 on Maine Calling

Optimizing your courses for online delivery

The COVID-19 pandemic is forcing many program directors and instructors to adjust their curriculum from face to face to online formats. Making that transition can be difficult especially if you...

Know Thy Mouse: Variability in Aged Mice

Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...

Building in silico research models to accelerate discovery

An interview with Anshul Kundaje Machine learning and deep learning in particular have a growing influence on everything from how we shop to how we drive—or are driven by self-driving cars. Anshul...

Choosing Diet Based NASH Models

What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...

Using JAX NSG™ Mice to Test CAR T Therapy for Breast Cancer

Studying cancer cell development, including signaling pathways and other types of cell-cell communications between immune cells and tumors, is critical to generating and evaluating...

Using prenatal cell-free DNA screening to prepare for a gender reveal – what prenatal providers and expectant parents should know

Camille is a 32 year-old woman at 10 weeks gestation in her first pregnancy. At her first prenatal appointment, Camille elects cell-free DNA screening for aneuploidy. She is not concerned about...

Want to know what to feed mice?

Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...

Nude Mice - More than What Meets the Naked Eye

The mouse is arguably the most widely used mammalian model in biomedical research. Their relatively small size, and both genetic and physiological similarity to humans, make mice a model organism...

Genetic testing can decrease but not rule out cancer risk

Breast cancer risk assessment is increasingly included in primary care. As a rule of thumb, approximately 5-10% of individuals with a breast cancer diagnosis will be found to carry a pathogenic...

Genomic medicine: Into the 2020s and beyond

2010-2012 – Exomes and engineering Seven years removed from the publication of the first human genome sequence, a lot of excited talk had yielded… well, very little clinically. The cost of...

Mouse Model of Niemann-Pick Type C Disease Reveals the Correlation Between Neuronal Cell Death and Motor Deficits

For decades, animal models have proven especially useful in revealing molecular changes for various conditions, including those in neurobiology. When researchers want to test existing or novel...

Cancer evolution and the future of therapy - Interview with Ramanuj Dasgupta

Ramanuj Dasgupta received his Ph.D. in developmental biology and genetics from the University of Chicago in 2002 and went on to complete a postdoctoral fellowship at Harvard Medical School. He...

Assessing Patient Health Risks with Limited or Unknown Family History

With November designated as Family Health History month, clinicians are sure to have seen lots of messaging encouraging their patients to discuss family health history around the Thanksgiving...