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Introduction: The History of “The Hallmarks of Cancer”Cancer researchers around the world are familiar with the landmark publication “The Hallmarks of Cancer,” initially set out by Hanahan and...
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This webinar provides a comprehensive, scientifically grounded overview of the diverse oncology model platforms available from The Jackson Laboratory
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This webinar explores the urgent need for innovative models and highlights JAX’s development of iPSC lines to advance understanding of PURA syndrome and enable drug discovery.
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Charu Gupta, Ph.D., Senior Technical Information ScientistKey PBMC Takeaways:Rapid engraftment: PBMCs engraft in 2-3 days with mature, human-protein expressing T cells.Human-relevant modeling:...
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Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...
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In this webinar, we share advice on maintaining mouse colonies that align with the 3Rs principles: replacement, reduction, and refinement.
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Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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The NntC57BL/6J mutation in the nicotinamide (NAD) nucleotide transhydrogenase (Nnt) gene is found exclusively in B6/J-derived mice and has not been detected in any other B6 substrains, including...
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This webinar provides key information about mouse strain nomenclature and genetic drift in the context of supporting research integrity.
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Learn about the MorPhiC Consortium and its initiative to generate a comprehensive catalog of molecular and cellular phenotypes for null alleles of every human protein-coding gene.
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As gene therapy continues to revolutionize modern medicine, the demand for reliable, translational, and ethically sound preclinical models has never been higher. In vivo gene delivery systems,...
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Cryopreservation is a powerful tool for colony management, protecting strains from loss while ensuring they remain available upon demand and at the scale needed (see IVF Speed Expansion...
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This document highlights the key differences between aged and young C57BL/6J mice when it comes to NASH.
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At The Jackson Laboratory (JAX), cryopreservation is a cornerstone of our research and colony management strategy. With decades of experience, we have optimized our cryopreservation protocols and...
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Sam Eck, Ph.D. - Technical Information ScientistIntroduction: The Historical Context of Sex Bias In 1993, the NIH issued the Revitalization Act which for the first time required the inclusion of...
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The Jackson Laboratory Contributes to Landmark Consensus Standards for Metabolic ResearchScientific progress depends on standardization. Just as consensus standards in genomics and metabolics...
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