How-to Guide for Selecting Xenografts & Mouse Models for Preclinical Cancer Research
If you’re gearing up to evaluate your drug candidates in clinically translatable, in vivo models, this webinar is for you.
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Learn. Engage. Connect.
If you’re gearing up to evaluate your drug candidates in clinically translatable, in vivo models, this webinar is for you.
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Join us as we discuss a collaborative effort between academia and a biopharmaceutical company, which utilized humanized mice to explore the role of mast cells in the melanoma tumor microenvironment.
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In this PubCast, we discuss a study from Yale University that employed humanized PBMC-NSG mice to model HIV and test the efficacy of two novel long-acting antiretroviral delivery systems. Resource
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In this presentation, we share a data-supported framework designed to trim costs, save time, and reduce the number of animals used for colony maintenance and cohort production.
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CD34 and PBMC humanized NSG mice are powerful preclinical models for studying the actions of immuno-modulators, either alone or in combination with other treatments.
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We review strategies and mouse models used to develop highly promising therapeutic treatments using the body’s own immune system in the fight against cancer.
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Limitations to scientific progress often arise not from a lack of curiosity or imagination, but rather from the tools and technologies available. While some research questions can be sufficiently...
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February 20, 2024 - During this presentation, we compare strategies for immune humanization of NSG variants to support translatable preclinical immunology and oncology research.
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In this webinar, we discuss cre-lox technology, a widely used and sophisticated tool to create general knockouts, conditional knockouts, and reporter strains.
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We recently published a paper in Journal of Genetic Counseling outlining our successful team-based approach to developing education for cardiology clinicians. Our collaboration with clinical and...
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During this seminar, we discuss unique experimental design considerations for mouse-based research.
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If you have ever screened a compound library and successfully killed tumor cells in a dish, you might be surprised to find that many of those compounds may have little or no effect when those...
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Immunodeficient mice are invaluable tools for immunology, infectious disease, oncology, hematopoietic, and regenerative medicine studies. They can serve as hosts for engraftment of mouse tumor...
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January 16, 2024 - In this webinar, we discuss the most widely used immunodeficient mouse models and essential considerations for selecting the most appropriate model.
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I started covering the field of human genomics in depth around 2008. It was a time when whole genome sequencing (WGS) still cost millions of dollars per genome, and genome editing methods were so...
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In this episode, we discuss the common discrepancies we encounter when strains are imported into The Jackson Laboratory’s repository and how JAX ensures our strains meet our high standards.
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Omitting sex as a biological variable has several consequences. Watch this webinar to learn the scientific impact sex bias has on your research.
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Learn about Hu-PBMC NSG models that can be used to test the efficacy of human T cell immunomodulatory therapeutics for graft-versus-host disease (GvHD), autoimmune disorders, and cancer.
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