A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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JAX Humanized Mice
With JAX Humanized Mice you can support multiple therapeutic approaches and leverage different components of the human immune system at the same time. This means getting to your research milestones faster and with more accurate data. Read our latest content to learn more about our solutions.
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Modeling Chimeric Antigen Receptor (CARS) and T Cell Bispecific (TCB) Therapies in Mice
Modeling chimeric antigen receptor (CARS) and T cell bispecific (TCB) therapies in mice
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JAX Antibody Development Summit - Jan Eckmann
Dr. Jan Eckmann, Group Leader Oncology Discovery Pharmacology at Roche, presents The Use of Humanized Mice in Antibody Drug Discovery as part of The Jackson Laboratory's Antibody Drug Development Summ
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Targeting Natural Killer Cell Activity with Humanized NSG IL-15 Mouse Model
The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.
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Transgenic Expression of Human IL15
Michael Brehm, University of Massachusetts Medical School Title: Transgenic expression of human IL15 in NOD-scid IL2rgnullmice enhances the development and survival of functional human NK cells
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Predicting CRS using humanized mice
Alba Matas Céspedes, Astra Zeneca Title: Use of human splenocytes in an innovative humanized mouse model for prediction of immunotherapy-inducedcytokine release syndrome
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IgG production in humanized mice
Sebastian Theobald, Hannover Medical School Title: Modeling human cytomegalovirus infections in humanized mice for preclinical development of novel cellular and antibody-based therapies
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Why humanized mice?
You may have noticed that the latest biomedical breakthroughs are utilizing more and more humanized mice. But, what is a humanized mouse and why would scientists want to utilize this type of...
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MiceTech Talk Episode 9: Let’s Talk Humanized Mice - Part 1 (July 14, 2020)
July 14, 2020 - In this episode, we cover the remaining murine immunity, the lack of engraftment of certain lineages, and what can be done about the lack of antigen-specific responses.
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MiceTech Talk Episode 10: Let's Talk Humanized Mice Part 2 (July 21, 2020)
July 21, 2020 - In this episode, we’ll highlight incredible new approaches to induce immune-mediated killing of tumors using mice with humanized immune systems.
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CD34+ Hematopoietic Stem Cell Humanized Mice: The Basics
Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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Advancing Humanized NSG Mice for Immuno-Oncology Efficacy Testing
Assessing novel therapeutics that function to modulate the interaction between the human immune system and cancer cells requires advanced preclinical efficacy testing platforms. Immunologically...
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Poster: Evaluation of Bispecific Antibody Efficacy and Drug-Induced Cytokine Release
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Improving Translational Relevance with Humanized NSG™ Mice
Watch this video to learn the process of generating and characterizing “humanized” NSG™ (Hu-NSG™) mice and view data demonstrating preclinical research applications of these novel mouse models.
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Case Study: Evaluation of the Anti-Tumor Efficacy of a Bispecific in Two Novel In Vivo Systems
The NSG Humanized Mouse platform is an efficient way to test bispecific antibodies, including CD3 binding bispecific. This case study highlights our recent data.
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