MODEL-AD: Creating new mouse models for late-onset Alzheimer’s disease
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Neurobiology
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Early Electrophysiology & Biochemical Biomarkers in Mouse Models for Amyotrophic Lateral Sclerosis.
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Mouse Models of Rett Syndrome
The establishment of a new platform to assess preclinical allele dependent phenotypes
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Overview of Friedreich’s Ataxia Models - Cat Lutz, Ph.D.
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MiceTech Talk Episode 22: Let’s Talk Exploring Neurobiology Solutions (Oct. 27, 2020)
In this episode, we share with you highlights of JAX preclinical research studies using mouse models for ALS, Rett Syndrome, Friedreich's Ataxia, and more!
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A View on ALS Drug Discovery - Learnings From the Front Lines of Translational Disease Modeling
Join Cat Lutz, Ph.D., Senior Director In Vivo Pharmacology & Mouse Repository at JAX as she'll discuss neurodegenerative diseases, rare diseases, and her group’s latest work in preclinical studies usi
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MiceTech Talk Episode 12: Let's Talk Latest Advances in Alzheimer's Disease Research (Aug. 4, 2020)
We highlight some of the latest studies and discoveries presented at the AAIC Conference, the most influential international meeting dedicated to advancing dementia science.
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Moving beyond amyloid to treat Alzheimer's disease
Beta-amyloid peptid. The amyloid precursor protein being cleaved by gamma and beta secretases and releasing the amyloid beta peptide, which can accumulate to amyloid plaques, one of the main...
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Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease
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FcRn: Preclinical Therapeutic Antibody and Albumin-Conjugate Evaluation
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The Versatile Mouse Model for Rare Disease Research
More than 7,000 rare (or orphan) diseases have been described so far and affect over 350 million people worldwide. Unfortunately, less than 10% of these diseases have an approved treatment, and...
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Revealing antibody half-life and stability using FcRn mouse models from JAX
The approval of Orthoclone OKT3® (muromonab-CD3) in 1986 marked the first appearance of monoclonal antibodies in the clinic. In the over 20 years since, more than 70 antibodies have been approved...
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Women in science: Huda Zoghbi discovered the genetic basis of Rett syndrome
Dr. Huda Zoghbi was born Huda El Hibri in 1955 in Beirut, Lebanon. Her father owned a business manufacturing olive oil and soap, and her mother stayed at home to raise Huda and her four siblings....
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Understanding the connection between heart and nerves in a rare form of SMA
SMARD is a disease that affects nerve cells. These are the cells that relay information from the brain through the spinal cord to different muscles in your body. This is kind of like the wires...
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“Optopatch”: A New Wrench for the Neurobiologist’s Toolbox
Optogenetic mice have been revolutionizing neuroscience research since they burst onto the scene in the first decade of the 21st century. In combination with an ever-expanding collection of cre...
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Rebels with a neurobiological cause: Mouse models explore teen nicotine addiction
The majority of new smokers are teens Tobacco use is started and established primarily during adolescence. Indeed, according to the National Institute of Drug Abuse (NIDA) nearly 60 percent of...
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Can I Outrun Alzheimer's Disease?
This is the third in a series about my genome sequence. I’ve already posted about my general thoughts and a conversation with a genetic counselor. Below I focus on the ApoE4 gene, the one...
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Beyond nature versus nurture
How much do our genomes determine about our lives? It’s a hard question to answer, and it arises in various forms. The nature (genes) versus nurture (environment) child rearing debate has raged...
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Alzheimer's disease and the complex puzzle of degeneration
Alzheimer’s disease is frightening. Incurable, progressive, burdensome and still biologically mysterious, it afflicts primarily the elderly and inexorably degenerates the brain tissue of patients....
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Light Up Your Research: Use and Selection of Optogenetic Mouse Models
This video reviews the basics of optogenetic mouse models and how researchers are using them to investigate neural circuitries underlying complex behaviors and neural diseases.
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