Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease
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Neurobiology
Neurobiology
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Mouse Model Generation: From Idea to Data
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Light Up Your Research: Use and Selection of Optogenetic Mouse Models
This video reviews the basics of optogenetic mouse models and how researchers are using them to investigate neural circuitries underlying complex behaviors and neural diseases.
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Booklet Neurobiology
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Generating Effective Mouse Models of Friedreich's Ataxia
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Working with ALS Mice: Guidelines for Preclinical Testing and Colony Management
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Research Using Aged B6 Mice: Considerations, Applications, and Best Practices
Aging studies are lengthy, resource-intensive, and require advance planning. This video highlights considerations for maximizing the translational value of data collected from aged research mice.
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Parkinson's Research Resources
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Proficiency with Larger Knockins
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Disaster Proofing Your Knowledge House: Tips to prepare your in vivo research for the worst
We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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Strategies to Minimize Genetic Drift
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600 trillion synapses and Alzheimers disease
Late-onset Alzheimer’s disease is extremely difficult to model in the laboratory, one reason why no successful therapy for it exists. But scientists are using new capabilities to create more...
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Want to know what to feed mice?
Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...
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Mouse Model of Niemann-Pick Type C Disease Reveals the Correlation Between Neuronal Cell Death and Motor Deficits
For decades, animal models have proven especially useful in revealing molecular changes for various conditions, including those in neurobiology. When researchers want to test existing or novel...
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Booklet Colony Management
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Booklet Mouse Models
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The Longest Day 2019
In what has become an annual event, researchers from The Jackson Laboratory Center for Alzheimer's and Dementia Research set out across Maine's Mount Desert Island to participate in The Longest...
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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If you’re happy and you know it, thank your bugs
Is there a relationship between your mental health and your gut microbiome? Research published in Nature Microbiology earlier this month suggests bidirectional communication between the brain...
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