Improved humanization of peripheral blood mononuclear cells in NSG-SGM3xIL15xDKO (S15-DKO) over that of NSG-MHC I/II DKO mice for immune-onc
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Humanized Mice
JAX humanized NSG mice represent an innovative and cost-effective platform to stimulate trials, evaluate multiple drugs alone or in combination, and produce reliable predicative data. Explore our collection of humanized mice resources and learn how this innovative platform models immunity to study and evaluate treatments for a variety of human diseases.
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Inducing memory humoral responses using multiple vaccines in PBMC humanized mice
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In vivo Lentiviral CAR-T Gene Delivery Demonstrates High Specificity and Potent anti-Tumor Activity in a Humanized B Cell Lymphoma Model
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In Vivo Evaluation of Autologous Anti-BCMA CAR-T Therapy in PBMC-humanized S15-DKO Mice Reveals Donor-specific Immune Responses
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A novel NSG-SGM3xIL15xDKO-based PBMC humanized mouse model to evaluate efficacy and cytokine release of immunotherapies
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Robust Engraftment of Human γδ T Cells in Humanized NSG-SGM3-IL-15 x MHC I/II Double Knockout Mice For the Evaluation of γδ T Cell-based The
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Use of Humanized Mouse Models in Drug Development - Voot Yin
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Human HSC & PBMC Platforms for In Vivo Immune Modulatory Drug Discovery
Watch this webinar to learn more about JAX's advanced humanized platforms that support in vivo human immune cell development and function.
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Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models
Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.
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Biology-Guided Design of Human Albumin Fusions
Presented by Jan Terje Andersen, Ph.D., Professor in Biomedical Innovation, University of Oslo
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Enhancing Antibody Development: Leveraging FcRn Transgenic Mice (tg32) for Drug Discovery of Therapeutic Antibodies
Presented by Martin Lechmann Ph.D., DMPK/PD Project Lead (DPL) Biologics, Roche Diagnostics GmbH
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Humanized FcRn Mouse Model for Evaluating PK and Allometric Scaling
Presented by Michael Kiffe, Ph.D., Director PK Sciences / Translational Medicine, & Monika Gajewska, Ph.D., M&S Group, PK Sciences, Novartis Pharma AG
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JAX Presentation - Use of Humanized Mouse Models in Drug Development - Brian Soper, Ph.D.
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Expedite Robust Outcomes of Biologics Efficacy Studies Using Humanized Mice
This webinar explores how to leverage humanized mouse models to expedite preclinical research in biologic therapeutics.by providing a rigorous scientific framework and practical insights for l
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Enhanced Development of Human Innate Immunity in Humanized Mice
Learn about JAX's enhanced innate immune models: the CD34+ engrafted NSG-FLT3 and NSG-FLT3-IL15 mice, presented by Michael Brehm, Ph.D., UMass Medical School.
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Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research
During this webinar, we will discuss the most widely used immunodeficient mouse models and important considerations for selecting the most appropriate model.
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JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice
In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.
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Humanized Mice for the Assessment of the Safety of Immunotherapies
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Next-Generation Humanized Models for the Preclinical Development of Therapeutic Antibodies
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Using the HuPK™ Platform to Predict the PK of Candidate Therapeutic Antibodies
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