Humanized Mice

Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models

Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.

Biology-Guided Design of Human Albumin Fusions

Presented by Jan Terje Andersen, Ph.D., Professor in Biomedical Innovation, University of Oslo

Enhancing Antibody Development: Leveraging FcRn Transgenic Mice (tg32) for Drug Discovery of Therapeutic Antibodies

Presented by Martin Lechmann Ph.D., DMPK/PD Project Lead (DPL) Biologics, Roche Diagnostics GmbH

Humanized FcRn Mouse Model for Evaluating PK and Allometric Scaling

Presented by Michael Kiffe, Ph.D., Director PK Sciences / Translational Medicine, & Monika Gajewska, Ph.D., M&S Group, PK Sciences, Novartis Pharma AG

Expedite Robust Outcomes of Biologics Efficacy Studies Using Humanized Mice

This webinar explores how to leverage humanized mouse models to expedite preclinical research in biologic therapeutics.by providing a rigorous scientific framework and practical insights for l

Enhanced Development of Human Innate Immunity in Humanized Mice

Learn about JAX's enhanced innate immune models: the CD34+ engrafted NSG-FLT3 and NSG-FLT3-IL15 mice, presented by Michael Brehm, Ph.D., UMass Medical School.

Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research

During this webinar, we will discuss the most widely used immunodeficient mouse models and important considerations for selecting the most appropriate model.

JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice

In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.

Humanized Mice for the Assessment of the Safety of Immunotherapies

Next-Generation Humanized Models for the Preclinical Development of Therapeutic Antibodies

Using the HuPK™ Platform to Predict the PK of Candidate Therapeutic Antibodies

New Directions for Therapeutic Antibody Formats: An Overview of Development Trends and the Current Clinical Pipeline

Comparing Immune-Humanized Mouse Platforms for Preclinical Applications

During this presentation, we will compare strategies for immune humanization of NSG variants to support translatable preclinical immunology, and oncology research. researchers a powerful tool for cha

NSG-FLT3-IL15: A More Comprehensive Immune Humanized Model for Natural Killer Cells

In this presentation, we introduce The Jackson Laboratory’s most comprehensive immune humanized mouse platform to date: NSG- FLT3-IL15.

JAX Humanized Mice PubCast: IBD, Tregs, IL-2 + NSG mice

Learn about an immune humanized model of irritable bowel disease (IBD) used to investigate the mechanism of action and evaluate the therapeutic efficacy of interleukin-2 in treating ulcerative colitis

Biologics Drug Development Gets an Upgrade with Humanized Animal Models

JAX Study Director Aaron Rose, Ph.D., explores how biological therapeutics are reshaping the drug development process and why humanized models are essential for advancing biologics programs.

JAX Humanized Mice PubCast: CD19-CD28 Bispecific + FcRn mouse model to predict human PK

In this PubCast, we delve into Roche’s integration of humanized mice in their preclinical drug development pipeline to assess the safety and efficacy of their CD19-CD28 bispecific.

JAX Humanized Mice PubCast: Mast cells & Anti-PD-1 Therapy (Apr. 3, 2024)

Join us as we discuss a collaborative effort between academia and a biopharmaceutical company, which utilized humanized mice to explore the role of mast cells in the melanoma tumor microenvironment.