Old Age and Diet Together in Mice Represent a Unique Model of Human NASH
Aged C57BL/6J mice represent a new dietary model for nonalcoholic steatohepatitis (NASH) that accounts for the known risk factor of age in the human disease.
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NASH Resources
NASH is a complex metabolic disease which can require the use of multiple mouse models to evaluate mechanistic details. Utilize JAX’s expansive portfolio of NASH models to support your research needs and validate key phenotypic endpoints including hepatic steatosis, ballooning, inflammation, and fibrosis.
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Genetically Diverse Mouse Models for Every Stage of the Research Pipeline
Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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Aged NASH Tech Spec Sheet
This document highlights the key differences between aged and young C57BL/6J mice when it comes to NASH.
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MiceTech Talk Episode 29: Let's Talk New Data on Old Mice (Feb. 2, 2021)
February 2, 2021 - In this episode, we will discuss new data in the field of aged mice and how it allows scientists to better represent disease in humans.
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MSNASH Tech Spec Sheet
Metabolic phenotypes expected from the JAX MSNASH/PcoJ Model
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A Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH) in Aged Male and Female C57BL/6J Mice
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Key Considerations for NASH Models
Join Danielle Fontaine, Ph.D. and Andrew Schile, Ph.D. on Wednesday, August 26 as they discuss the NASH mouse models and what to consider when choosing the appropriate model for your study.
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Choosing Diet Based NASH Models
What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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Choosing the Best Mouse Models for Your NASH Research
Gain insights into the array of mouse models that can be used for nonalcoholic steatohepatitis (NASH) research and their translational relevance.
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Welcome MSNASH/PcoJ: the latest mouse model from JAX
Introduction Finding the most translationally-relevant mouse model is vital to generating meaningful and reproducible data, and critical in the development of disease therapeutics. However, for...
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Finding “DIAMONDS” in the rough – serendipity in research
The hardest thing to see is what is in front of your eyes.– Johann Wolfgang von Goethe That Goethe quote was taped to one of my mentor’s microscopes and I thought of it when a recent article...
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