PEGS EU 2023 - Translational Humanized Models for Immunotherapy Drug Development
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Immunology Resources
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Rapid In Vivo Evaluation of Immuno-Modulatory Therapies Using Hu-PBMC NSG™ Mice
Learn about Hu-PBMC NSG models that can be used to test the efficacy of human T cell immunomodulatory therapeutics for graft-versus-host disease (GvHD), autoimmune disorders, and cancer.
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The Application of Humanized Mice in Manipulation of Myeloid Cells - Dr. Ali Roghanian
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In Vivo Platforms for Autoimmune Pharmacology: MS-EAE Capabilities
Watch this webinar to learn about Experimental Autoimmune Encephalomyelitis (EAE), which serves as the gold standard preclinical model for MS research.
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CRS Highlights for EU Symposium
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CAR T studies with significantly delayed onset of GvHD
Assessing efficacy and toxicity in CAR-T studies in an accessible translational model. The Jackson Laboratory's in vivo PBMC-humanized mouse platform provides a wider window to look at cytokine releas
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Potency of PD-1+CTLA-4 Bispecific or Combination in a Humanized Mouse Model
Presented by Richard Stebbings, Ph.D., Senior Director Oncology Safety Science, AstraZeneca
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Of Mice and Men - FcRn Biology and Its Implications in a Therapeutic Perspective - Jan Terje Andersen, Ph.D.
Of mice and men - FcRn biology and its implications in a therapeutic perspective Presented by Jan Terje Andersen, Ph.D. - Professor in Biomedical Innovation, University of Oslo, Co-founder, Authera,
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Preclinical Assessment of Engineered Immunoglobulins in Immune Humanized Mice - Brian Soper, Ph.D.
Preclinical Assessment of Engineered Immunoglobulins in Immune-humanized Mice Presented by Brian Soper, Ph.D. - Senior Scientific Engagement Manager, The Jackson Laboratory, Bar Harbor, USA Presen
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Mouse Models of Coronavirus Infection
In this webinar, we discuss upcoming and established strains in the JAX COVID-19 Model Portfolio, in the context of in vivo findings with SARS-CoV2 and related viruses.
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JAX Tech Talk Episode 51: Let’s Talk Accelerating Research with JAX’s GvHD Platform (Mar. 1, 2022)
March 1, 2022 - In this episode, the JAX Tech Talk Team welcomes Prabir Banerjee to discuss the JAX GvHD platform and its value in accelerating your preclinical research studies.
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NOD/scid IL-2Rγnull Mice Reconstituted with Peripheral Blood Mononuclear Cells of Crohn’s Disease
Veronika Weß leads an informative discussion on the use of the immune-humanized mouse platform to explore the biological underpinnings of inflammatory bowel disease (IBD).
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Studying Complex, Systemic Immune Responses in Humanized Mice
Although many mammals have immune systems that share important characteristics with humans, certain immune cell types and phenomena are unique to us. As a result, it has been difficult to design...
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JAX Tech Talk Episode 49: Let’s Talk COVID Models - 2022 Updates (Feb. 1, 2022)
February 1, 2022 - With COVID-19 research ever-evolving and novel research results becoming available, Team JAX Tech Talk looks to discuss the newest advancements in the field.
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JAX Tech Talk Episode 44: Let's Talk Grants for Genetic Background’s Impact on Translatability (Oct. 5, 2021)
October 5, 2021 - Is your treatment robust enough to "work" in different genetic backgrounds? Are your preclinical studies assessing translatability? In this episode, we will explore: how J:DO mice m
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JAX Tech Talk Episode 43: Let’s Talk Assessing Efficacy of GvHD Therapeutics (Sept. 14, 2021)
September 14, 2021 - In this episode, we discuss how the xenogeneic GvHD model in NSG mice aligns with your drug development pipeline.
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GvHD Efficacy Study Fact Sheet
An example of study information provided when conducting a GvHD study with the Jackson Laboratory. This example shows Bispecific Antibodies in comparison with Abatacept.
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Important Considerations for Generating Genetic Humanized Mouse Models
The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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Genetically Diverse Mouse Models for Every Stage of the Research Pipeline
Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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JAX Antibody Development Summit - Dave Serreze
Dr. Dave Serreze, Professor, The Jackson Laboratory, presents Targeting Autoreactive B-cells Contributing to Type 1 Diabetes Development as part of The Jackson Laboratory's Antibody Drug Development S
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