2022 SfN Poster: TGN1412-Induced Cytokine Release Syndrome and Pathological Evaluation in a Humanized PBMC Mouse Model
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Immunology
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Important Considerations for Generating Genetic Humanized Mouse Models
The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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Genetically Diverse Mouse Models for Every Stage of the Research Pipeline
Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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MiceTech Talk Episode 35: Let's Talk SARS-CoV-2 Testing in Mouse Models (Apr. 27, 2021)
April 27, 2021 - In this episode, we discuss the latest research on the topic and provide up-to-date information on current best practices.
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MiceTech Talk Episode 34: Let’s Talk Scientific Sessions – Oncology (Apr. 13, 2021)
April 13, 2021 - In today’s episode, we will discuss the latest developments in oncology research which were shared during the April 7, 2021 JAX Scientific Session.
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Oncology Session - April 7, 2021, Aaron Rose, Ph.D.
Talk Title: Are Young Mice the Right Tool for Evaluation of Immunotherapeutics? Aged C57Bl/6J Mice for Syngeneic Studies
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CRS: FAQs
The JAX CRS assay has a highly flexible design applicable to a wide variety of human specific immune modulatory therapies. The assay can test both immunostimulatory and immunosuppressive therapies.
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Novel antibody tests reveal complexity of immune response to covid-19
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CAR T therapy testing—how it started and how it’s going
At The Jackson Laboratory (JAX), we are working with our customers to test CAR T efficacy in solid and disseminated tumors and investigate new models of efficacy and safety testing of this nascent the
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Exclusively from JAX: The COVID-19 Model Portfolio
We invite you to explore our comprehensive portfolio of COVID-19 models.
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Using Humanized In Vivo Models for Preclinical Antibody Development: A Case Study
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Targeting Natural Killer Cell Activity with Humanized NSG IL-15 Mouse Model
The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.
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MiceTech Talk Episode 24: Let's Talk Caring for Immunodeficient Mice (Nov. 17, 2020)
November 17, 2020 - In this episode, we share recommendations from our JAX clinical veterinary team on caring for immunodeficient mice.
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An Introduction to Human FcRn Mice - Greg Christianson
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JAX Guide: Assessing Antibody Pharmacokinetics Using the JAX FcRn Platform
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Case Study: PK/PD, Safety, and Efficacy Platforms
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Poster: PK/PD, Safety, and Efficacy Platforms
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Preclinical Evaluation of Efficacy and Cytokine Release of Bispecific T Cell Engagers in Hu-NSG Mice
Dr. Li-Chin Yao of The Jackson Laboratory outlines her latest work on humanized NSG mice to test efficacy and cytokine release of bispecific T cell engagers
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An In Vivo Model to Evaluate Donor-Dependent Cytokine Release
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Effects of Aging on Immunosenescence and Checkpoint Inhibitor Efficacy in a C57BL/6J Syngeneic Model
Dr. Jiwon Yang discusses establishing a mouse model that exhibits immunosenescence and studying how immunosenescence affects checkpoint inhibitor efficacy in a C57BL/6J syngeneic model.
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