Achieving Relevant Preclinical Characterization of CAR T Cell Therapies

This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.

A MHC Class I & II Deficient Platform Humanized with PBMCs

JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.

CRS Studies for CAR T Cell Therapy

Review JAX’s CRS evaluation capabilities and see how a CRS study can help move your CAR T therapeutic into the clinic faster, safer, and more confidently.

Preclinical Drug Development Fact Sheet

A glimpse at the wide range of platforms and services JAX offers to help move you from drug discovery to IND filing.

Poster: TGN1412-Induced Cytokine Release Syndrome and Pathological Evaluation in a Humanized PBMC Mouse Model

A New Way to Study Cytokine Release Syndrome

In vivo CRS assays have the potential to simultaneously derisk and accelerate the process of bringing successful therapies to the patients who need them most.