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Immune Humanized Mice
Use of Humanized Mouse Models in Drug Development - Voot Yin

Use of Humanized Mouse Models in Drug Development - Voot Yin

Published Date November 26, 2025

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Next-Gen Immune-Humanized Models for Antibody Drug Development

Dr. Brian Soper, Senior Scientific Engagement Manager at The Jackson Laboratory, presents Next-Gen Immune-Humanized Models for Antibody Drug Development
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Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models

Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.

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6 days ago
Next-Gen Immune-Humanized Models for Antibody Drug Development

Dr. Brian Soper, Senior Scientific Engagement Manager at The Jackson Laboratory, presents Next-Gen Immune-Humanized Models for Antibody Drug Development

Watch Video
4 months ago
Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models

Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.

Watch Video
8 months ago
JAX Presentation - Use of Humanized Mouse Models in Drug Development - Brian Soper, Ph.D.

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5 months ago
Translatable Efficacy & Safety Testing of mAb, Bispecific, & CAR T Therapies

During this webinar, we discuss preclinical data showcasing efficacy and safety testing of immunotherapies in immune humanized mouse models.

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about 2 years ago
SITC 2023 Comparison of Blinatumomab and Biosimilar CD19xCD3 BiTE responses in PBMC-Humanized Mice Used as a Preclinical Lymphoma Mouse Mode

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about 2 years ago
SITC 2023 PBMC Humanized Mouse Model with Clinical Relevance in Assessing the Safety Profile of 4-1BB Agonist, Urelumab, in 5 Donors

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5 months ago
New Immune-humanized Models Support More Diverse Human Immune Cell Lineages

In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.

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about 2 years ago
PEGS EU 2023 - Translational Humanized Models for Immunotherapy Drug Development

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about 2 years ago
CD34+ Hu-NSG-SGM3-IL15 Tech Sheet

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over 2 years ago
Evaluation of Safety and Efficacy of Antibody Therapies in Humanized Mice_Dr. James Keck

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over 2 years ago
A Novel PBMC Humanized Mouse Model_Dr. James Keck

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over 2 years ago
A humanized mouse model to study activity of cytotoxic and immunomodulatory human IgG - Dr. Anja Lux

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over 2 years ago
The Application of Humanized Mice in Manipulation of Myeloid Cells - Dr. Ali Roghanian

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over 2 years ago
The Next Generation of Humanized Mice for Translational Research - Dr. Michael Brehm

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over 2 years ago
Immunobiology of Human Immune Engrafted Platforms for Preclinical Drug Discovery - Dr. Brian Soper

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over 2 years ago
Humanized (NRG) Mice Supplemented with Dendritic Cells, Herpes Viruses or Lentiviral Vaccines Mount Antigen-Specific T and B Responses - Dr.

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5 months ago
Humanized Mice: Activity of Cytotoxic and Immunomodulatory IgG Antibodies

Anja Lux, PhD, Friedrich Alexander University, speaking at The Jackson Laboratory EU Symposium. A humanized mouse model to study activity of cytotoxic and immunomodulatory human IgG antibodies.

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5 months ago
Humanized Mice: Application of Humanized Mice in Manipulation of Myeloid Cells

Ali Roghanian, PhD, University of Southampton speaking at The Jackson Laboratory EU Symposium. The application of humanized mice in manipulation of myeloid cells.

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over 2 years ago
Humanized Mice Highlights for EU Symposium

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5 months ago
CD34+ Humanized Mice

Human cord blood-derived hematopoietic CD34+ stem cells. Validated: greater than 25% human CD45+ cells in peripheral blood. Humanized NSG variants (hu-CD34+). Infectious disease, gene therapy, cancer,

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