February 7, 2023 - In this episode, we discuss the importance of studying rare diseases and the critical preclinical steps leading to diagnosis and treatment development.
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Christian Münz, Ph.D. - Professor and Co-director of the Institute of Experimental Immunology, University of Zürich, Switzerland Talk Title: Humanized mouse models for the influence of genetic variati
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Join Cat Lutz, Ph.D., Senior Director In Vivo Pharmacology & Mouse Repository at JAX as she'll discuss neurodegenerative diseases, rare diseases, and her group’s latest work in preclinical studies usi
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Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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For decades, animal models have proven especially useful in revealing molecular changes for various conditions, including those in neurobiology. When researchers want to test existing or novel...
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Dr. Huda Zoghbi was born Huda El Hibri in 1955 in Beirut, Lebanon. Her father owned a business manufacturing olive oil and soap, and her mother stayed at home to raise Huda and her four siblings....
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SMARD is a disease that affects nerve cells. These are the cells that relay information from the brain through the spinal cord to different muscles in your body. This is kind of like the wires...
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Bruce Curran, right, speaks with JAX researcher David Bergstrom, Ph.D., during a Rare Disease Day 2016 event at the Maine State House. Curran is battling Inclusion Body Myositis, a rare...
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This video reviews the basics of optogenetic mouse models and how researchers are using them to investigate neural circuitries underlying complex behaviors and neural diseases.
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The NSG™ mouse model is used by investigators worldwide to advance research in cancer, infectious diseases, and immunological disorders. Watch this video to learn how to care for NSG™ Mice.
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More than 7,000 rare (or orphan) diseases have been described so far and affect over 350 million people worldwide. Unfortunately, less than 10% of these diseases have an approved treatment, and...
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Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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View the suite of next generation NSG models.
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Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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