Achieving Relevant Preclinical Characterization of CAR T Cell Therapies

This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.

A MHC Class I & II Deficient Platform Humanized with PBMCs

JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.

A New Way to Study Cytokine Release Syndrome

In vivo CRS assays have the potential to simultaneously derisk and accelerate the process of bringing successful therapies to the patients who need them most.

Eight Considerations for Designing Studies with Aged Mice

Comprehensive Evaluation of Human Immune System Reconstitution in NSG and NSG-SGM3 Mouse Models

Humanized NSG Mice for Infectious Disease Research

Strategies to Minimize Genetic Drift

Aged C57BL/6J Mice for Research Studies