When are mice considered old?
Mice are widely used models for both aging and senescence because of their similarity to humans. These two terms, though often used interchangeably, are not the same. Aging refers to biological...
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Aging Resources
Some diseases, such as Alzheimer's and cancer, develop later in life— both in humans and mice. Here are our aged mouse resources.
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important...
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JAX Aging Services
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Including Aged Mice in Immuno-Oncology Research
Introduction The famous author, Betty Friedan, once said: "Aging is not lost youth but a new stage of opportunity and strength." This powerful quote not only applies to life, but to those...
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Aged C57BL/6J Mice for Research Studies
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Research Using Aged B6 Mice: Considerations, Applications, and Best Practices
Aging studies are lengthy, resource-intensive, and require advance planning. This video highlights considerations for maximizing the translational value of data collected from aged research mice.
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Eight Considerations for Designing Studies with Aged Mice
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What is a normal phenotype for aging mice?
No substitute for proper controls When making a determination as to whether an experimental outcome is related to a mutation or treatment, there is no substitute for proper controls: contemporary...
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Aged C57BL/6J Mouse Models
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Investigating Stroke Therapeutic Targets Using JAX Aged C57BL/6J Mice
Introduction The brain is a highly complex organ comprised of a large number of cells and molecules, each with its own unique function. Diseases that affect the central nervous system (CNS), such...
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