Generating Better Mouse Models for Your Research: Approaches and Considerations
Check out this video for experience-based insights that can help you make decisions during your model development process.
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Essentials
Essentials
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Genetic Drift – What It Is and How to Minimize Its Impact on Your Research
Watch this video to learn how The Jackson Laboratory's unique Genetic Stability Program effectively limits cumulative genetic drift.
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CD34+ Hematopoietic Stem Cell Humanized Mice: The Basics
Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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Making Sense of Mouse Nomenclature and Promoting Genetic Stability
Learn how maintaining genetic stability is critical to generating the most reliable and reproducible data.
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Best Practices for Efficient Colony Management
Watch this video to learn how to manage mouse colonies more efficiently in today's economic climate.
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Cre-lox Basics: Cre-lox Technology in Mouse Modeling
Watch this video to learn about the principles of the technology, basic research applications and how to access the world’s largest collection of Cre-lox strains.
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Achieving Reproducible Mouse Studies
Success in the drug development pipeline depends on success in basic and preclinical research. Watch this video to learn about unique experimental design considerations for mouse-based research.
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Generating Mouse Models Using CRISPR/Cas9 Technology
Watch this video to understand the potential of CRISPR/Cas to accelerate your research.
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Designing & Optimizing Mouse Breeding Schemes
Watch this video to get a refresher on the fundamentals of basic mouse genetics and learn some tricks from our experts to plan your next experiment better.
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The ABC’s of CAR T Cell Therapies
All that glitters… Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor T-cells, promoting their own...
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JAX Handbook: Genetically Standardized Mice
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Appendix 2: MHC H2 Haplotypes
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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Choosing Diet Based NASH Models
What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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Want to know what to feed mice?
Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...
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Nude Mice - More than What Meets the Naked Eye
The mouse is arguably the most widely used mammalian model in biomedical research. Their relatively small size, and both genetic and physiological similarity to humans, make mice a model organism...
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Disaster Proofing Your Knowledge House: Tips to prepare your in vivo research for the worst
We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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