Robust CAR-T Memory Formation and Function via Hematopoietic Stem Cell Delivery
Scott Kitchen, PH.D., Director of UCLA CFAR/JCCC Humanized Mouse Laboratory, presents at Humanized Mice Journal Club on October 26, 2021.
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Infectious Disease
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Novel antibody tests reveal complexity of immune response to covid-19
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Exclusively from JAX: The COVID-19 Model Portfolio
We invite you to explore our comprehensive portfolio of COVID-19 models.
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Improving Translational Relevance with Humanized NSG™ Mice
Watch this video to learn the process of generating and characterizing “humanized” NSG™ (Hu-NSG™) mice and view data demonstrating preclinical research applications of these novel mouse models.
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Battling COVID-19; A New Model of Cytokine Release Syndrome
Under certain circumstances in patients, the human immune system can spin out of control and become highly toxic, resulting in cytokine release syndrome (CRS). CRS has been observed in certain...
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JAX LIVE! A Dialogue on Immunotoxicity and COVID-19-related CRS
Join James Keck, Ph.D. and Aaron Rose, Ph.D. as they discuss testing potential Cytokine Release Syndrome therapies for COVID-19.
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Top Tips on Selecting the “Best” Immunodeficient Mouse Model for Your Research
Immunodeficient mice are invaluable tools for immunology, infectious disease, oncology, hematopoietic, and regenerative medicine studies. They can serve as hosts for engraftment of mouse tumor...
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hACE2 Transgenic Model For COVID-19 Research
In this broadcast, Drs. Cat Lutz and Qiming Wang discuss the new hACE2 transgenic platform and answer questions from viewers.
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Modeling Infectious Disease in the Mouse: Challenges and Innovations
Watch this video to learn how JAX inbred mouse strains can be used to model infection as well as treatment and prevention of human infectious diseases.
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Battling HIV with CRISPR
The availability of combination antiretroviral therapies that inhibit HIV replication in cells and robustly reduce plasma viremia means that HIV infections are survivable rather than fatal....
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Finally! Two mouse models to combat Zika virus
The rapid spread of the Zika virus into the US from Central and South America has US Health Officials at the CDC sounding the alarm and lobbying congress for more funding to combat the spread...
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Humanized NSG™ Mice for HIV Research
Infection with HIV (human immunodeficiency virus) is the underlying cause of AIDS (acquired immunodeficiency syndrome). By 2014, nearly 37 million people worldwide were infected with HIV, and...
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An Update: Trends in Ebola Research
Although it has been over a year since the Ebola virus (EBOV) outbreak in West Africa, many survivors are still suffering from chronic virus infection as well as from the devastation of having...
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Tips & Tricks for Care of NSG Mice
The NSG™ mouse model is used by investigators worldwide to advance research in cancer, infectious diseases, and immunological disorders. Watch this video to learn how to care for NSG™ Mice.
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Mouse Kidney Parvovirus: Here’s what you need to know
Researchers in Australia and North America have recently identified a novel parvovirus in laboratory mice: the Mouse Kidney Parvovirus (MKPV; Roediger B et al., 2018). A similar virus was...
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Humanized NSG Mice for Infectious Disease Research
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Humanized Mouse Models: Applications in Oncology & Infectious Disease
Our panel of experts will discuss the successes and caveats of using humanized mouse models to understand disease biology and evaluate therapeutic strategies.
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Strategies To Minimize Genetic Drift And Maximize Experimental Reproducibility In Mouse Research
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