Choosing Diet Based NASH Models
What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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Metabolic
Metabolic
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Tips for Working with Diabetic Mice
Genetic alterations predispose mice to develop human-like diabetes phenotypes. Watch this video to learn how to care for diabetic mice and what environmental factors can affect those phenotypes.
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Finding “DIAMONDS” in the rough – serendipity in research
The hardest thing to see is what is in front of your eyes.– Johann Wolfgang von Goethe That Goethe quote was taped to one of my mentor’s microscopes and I thought of it when a recent article...
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Choosing the Best Mouse Models for Your NASH Research
Gain insights into the array of mouse models that can be used for nonalcoholic steatohepatitis (NASH) research and their translational relevance.
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Novel Models Developed for Type 1 Diabetes Target Validation Studies
A direct way to test whether a specific genomic variant plays a role in disease etiology and progression– namely to validate it as a potential target for therapy- is to introduce a corresponding...
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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5 Common Questions for Diabetic Models
In a previous blog post, we discussed some important Do’s and Don’ts of working with diabetic mouse models. Here we will discuss some of the most common questions we get from investigators who are...
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Zygote Editing of a NOD Mouse to Better Understand the Mechanism of Diabetes
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Welcome MSNASH/PcoJ: the latest mouse model from JAX
Introduction Finding the most translationally-relevant mouse model is vital to generating meaningful and reproducible data, and critical in the development of disease therapeutics. However, for...
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If you’re happy and you know it, thank your bugs
Is there a relationship between your mental health and your gut microbiome? Research published in Nature Microbiology earlier this month suggests bidirectional communication between the brain...
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Booklet Colony Management
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Booklet Mouse Models
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Want to know what to feed mice?
Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...
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Disaster Proofing Your Knowledge House: Tips to prepare your in vivo research for the worst
We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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