JAX Metabolism & Type 2 Diabetes In Vivo Services
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Metabolic
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Old Age and Diet Together in Mice Represent a Unique Model of Human NASH
Aged C57BL/6J mice represent a new dietary model for nonalcoholic steatohepatitis (NASH) that accounts for the known risk factor of age in the human disease.
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Diet Composition of Diet-Induced Obesity in Mice
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Aged NASH Tech Spec Sheet
This document highlights the key differences between aged and young C57BL/6J mice when it comes to NASH.
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MSNASH Tech Spec Sheet
Metabolic phenotypes expected from the JAX MSNASH/PcoJ Model
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Overcoming the Challenges of Working With Diabetic Mice
In this seminar, we discuss the environmental factors that can influence diabetic phenotypes and can confound research results.
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A Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH) in Aged Male and Female C57BL/6J Mice
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Key Considerations for NASH Models
Join Danielle Fontaine, Ph.D. and Andrew Schile, Ph.D. on Wednesday, August 26 as they discuss the NASH mouse models and what to consider when choosing the appropriate model for your study.
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Tomorrow's Autoimmune Research Today: Mouse Models, Type 1 Diabetes, and More
An Interview with Professor Dave Serreze, Ph.D. and Jennifer Dwyer, Ph.D. on Type-1 Diabetes and Autoimmune diseases. Learn More Here: https://www.jax.org/explore-by-topic/diabetes/type-1-diabetes
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Choosing Diet Based NASH Models
What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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Choosing Among Type II Diabetes Mouse Models
JAX has been distributing mouse models for type II diabetes (Non-insulin Dependent Diabetes; NIDD; T2D) since the 1960s, and today there are several models to choose from. Unfortunately, no...
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Finding “DIAMONDS” in the rough – serendipity in research
The hardest thing to see is what is in front of your eyes.– Johann Wolfgang von Goethe That Goethe quote was taped to one of my mentor’s microscopes and I thought of it when a recent article...
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Choosing the Best Mouse Models for Your NASH Research
Gain insights into the array of mouse models that can be used for nonalcoholic steatohepatitis (NASH) research and their translational relevance.
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Novel Models Developed for Type 1 Diabetes Target Validation Studies
A direct way to test whether a specific genomic variant plays a role in disease etiology and progression– namely to validate it as a potential target for therapy- is to introduce a corresponding...
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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5 Common Questions for Diabetic Models
In a previous blog post, we discussed some important Do’s and Don’ts of working with diabetic mouse models. Here we will discuss some of the most common questions we get from investigators who are...
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Zygote Editing of a NOD Mouse to Better Understand the Mechanism of Diabetes
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Welcome MSNASH/PcoJ: the latest mouse model from JAX
Introduction Finding the most translationally-relevant mouse model is vital to generating meaningful and reproducible data, and critical in the development of disease therapeutics. However, for...
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If you’re happy and you know it, thank your bugs
Is there a relationship between your mental health and your gut microbiome? Research published in Nature Microbiology earlier this month suggests bidirectional communication between the brain...
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