Reproductive Biology of Mice
This video reviews mouse reproductive biology, focusing on optimizing the breeding productivity of research mouse colonies.
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Metabolic
Metabolic
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Making Sense of Mouse Nomenclature and Promoting Genetic Stability
What is in a name? From mouse strain nomenclature, you can determine genetic background, genetic modifications, who created the strain and who currently distributes it.
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Best Practices for Efficient Colony Management
In today's economic climate, research funding and vivarium space are becoming increasingly limited. As a result, investigators are challenged with managing their mouse colonies more efficiently.
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Tips for Working with Diabetic Mice
Genetic alterations predispose mice to develop human-like diabetes phenotypes. However, overlooking the environmental factors that influence those phenotypes can confound research results.
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Designing & Optimizing Mouse Breeding Schemes
Have you ever had to delay an experiment because you didn’t design your breeding scheme to produce enough knockout (KO) or control mice? Are you unsure of the most efficient way to set up your cross?
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Mouse Model Generation: From Idea to Data
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Booklet_Colony_Management
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Booklet_Mouse_Models
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Zygote Editing of a NOD Mouse to Better Understand the Mechanism of Diabetes
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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Choosing Diet Based NASH Models
What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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Want to know what to feed mice?
Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...
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Disaster Proofing Your Knowledge House: Tips to prepare your in vivo research for the worst
We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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5 Common Questions for Diabetic Models
In a previous blog post, we discussed some important Do’s and Don’ts of working with diabetic mouse models. Here we will discuss some of the most common questions we get from investigators who are...
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Novel Models Developed for Type 1 Diabetes Target Validation Studies
A direct way to test whether a specific genomic variant plays a role in disease etiology and progression– namely to validate it as a potential target for therapy- is to introduce a corresponding...
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Welcome MSNASH/PcoJ: the latest mouse model from JAX
Introduction Finding the most translationally-relevant mouse model is vital to generating meaningful and reproducible data, and critical in the development of disease therapeutics. However, for...
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If you’re happy and you know it, thank your bugs
Is there a relationship between your mental health and your gut microbiome? Research published in Nature Microbiology earlier this month suggests bidirectional communication between the brain and...
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