TechSpec_Aged NASH models
This document highlights the key differences between aged and young C57BL/6J mice when it comes to NASH.
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This document highlights the key differences between aged and young C57BL/6J mice when it comes to NASH.
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Metabolic phenotypes expected from the JAX MSNASH/PcoJ Model
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In this seminar, we discuss the environmental factors that can influence diabetic phenotypes and can confound research results.
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Join Danielle Fontaine, Ph.D. and Andrew Schile, Ph.D. on Wednesday, August 26 as they discuss the NASH mouse models and what to consider when choosing the appropriate model for your study.
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What is NASH? Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the United States. Liver disease is often closely associated with obesity and...
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The hardest thing to see is what is in front of your eyes.– Johann Wolfgang von Goethe That Goethe quote was taped to one of my mentor’s microscopes and I thought of it when a recent article...
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Gain insights into the array of mouse models that can be used for nonalcoholic steatohepatitis (NASH) research and their translational relevance.
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A direct way to test whether a specific genomic variant plays a role in disease etiology and progression– namely to validate it as a potential target for therapy- is to introduce a corresponding...
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Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important when it comes to aging studies...
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In a previous blog post, we discussed some important Do’s and Don’ts of working with diabetic mouse models. Here we will discuss some of the most common questions we get from investigators who are...
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Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Introduction Finding the most translationally-relevant mouse model is vital to generating meaningful and reproducible data, and critical in the development of disease therapeutics. However, for...
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Is there a relationship between your mental health and your gut microbiome? Research published in Nature Microbiology earlier this month suggests bidirectional communication between the brain...
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Mouse nutrition is a complex and multifaceted topic, especially in preclinical research. Diets have an enormous impact on the overall health and welfare of mice, their development, and changes to...
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We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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