Mouse Strains for the Study of Common Autoimmune Diseases
In this webinar, we discuss strains available from JAX that have yielded insight into lupus, psoriasis, Type I Diabetes, and Multiple Sclerosis.
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Autoimmune/Inflammation
The Jackson Laboratory has developed and validated numerous autoimmune in vivo models to interrogate therapeutic candidates in a relevant and translational manner. These platforms and readouts can help you make informed decisions about which candidates to move forward towards IND.
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In Vivo Platforms for Autoimmune Pharmacology: MS-EAE Capabilities
Watch this webinar to learn about Experimental Autoimmune Encephalomyelitis (EAE), which serves as the gold standard preclinical model for MS research.
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Genetically Diverse Mouse Models for Every Stage of the Research Pipeline
Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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Crafting a Precise Genetic Mouse Model with JAX
Craft the ideal model with JAX's Model Generation Services to design and produce the genetically modified mouse model that is precisely what you need for your research.
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HuMouse models for the influence of genetic variation on the immune control of Epstein Barr
Christian Münz, Ph.D. - Professor and Co-director of the Institute of Experimental Immunology, University of Zürich, Switzerland Talk Title: Humanized mouse models for the influence of genetic variati
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CAR T therapy testing—how it started and how it’s going
At The Jackson Laboratory (JAX), we are working with our customers to test CAR T efficacy in solid and disseminated tumors and investigate new models of efficacy and safety testing of this nascent the
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Tomorrow's Autoimmune Research Today: Mouse Models, Type 1 Diabetes, and More
An Interview with Professor Dave Serreze, Ph.D. and Jennifer Dwyer, Ph.D. on Type-1 Diabetes and Autoimmune diseases. Learn More Here: https://www.jax.org/explore-by-topic/diabetes/type-1-diabetes
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Moving beyond amyloid to treat Alzheimer's disease
Beta-amyloid peptid. The amyloid precursor protein being cleaved by gamma and beta secretases and releasing the amyloid beta peptide, which can accumulate to amyloid plaques, one of the main...
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Using Autoimmune Disease Models in Pre-clinical Drug Discovery
What are the best mouse models for studying autoimmune disease? What in vivo services are available for pre-clinical autoimmune research? Watch this live stream for the answers.
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CD34+ Hematopoietic Stem Cell Humanized Mice: The Basics
Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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Tips & Tricks for Care of NSG Mice
The NSG™ mouse model is used by investigators worldwide to advance research in cancer, infectious diseases, and immunological disorders. Watch this video to learn how to care for NSG™ Mice.
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The ABC’s of CAR T Cell Therapies
All that glitters… Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor...
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Light Up Your Research: Use and Selection of Optogenetic Mouse Models
This video reviews the basics of optogenetic mouse models and how researchers are using them to investigate neural circuitries underlying complex behaviors and neural diseases.
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Know Thy Mouse: Variability in Aged Mice
Before undertaking a large study, it’s very beneficial to understand the biology of the model you are going to work with. This is particularly important...
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Investigating immunomodulation: Examining GvHD using Humanized NSG™ mice from JAX
Novel treatment strategies for GvHD Graft-versus-Host Disease (GvHD), a systemic inflammatory condition, is the result of a reaction between transplanted donor T cells recognizing the antigenic...
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Strategies To Minimize Genetic Drift And Maximize Experimental Reproducibility In Mouse Research
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Research Using Aged B6 Mice: Considerations, Applications, and Best Practices
Aging studies are lengthy, resource-intensive, and require advance planning. This video highlights considerations for maximizing the translational value of data collected from aged research mice.
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NSG Models: The Most Versatile Immunodeficient Strain
View the suite of next generation NSG models.
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Revealing antibody half-life and stability using FcRn mouse models from JAX
The approval of Orthoclone OKT3® (muromonab-CD3) in 1986 marked the first appearance of monoclonal antibodies in the clinic. In the over 20 years since, more than 70 antibodies have been approved...
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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