Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models
Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.
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Immuno-Oncology/Oncology
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Enhanced Development of Human Innate Immunity in Humanized Mice
Learn about JAX's enhanced innate immune models: the CD34+ engrafted NSG-FLT3 and NSG-FLT3-IL15 mice, presented by Michael Brehm, Ph.D., UMass Medical School.
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Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research
During this webinar, we will discuss the most widely used immunodeficient mouse models and important considerations for selecting the most appropriate model.
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JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice
In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.
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Comparing Immune-Humanized Mouse Platforms for Preclinical Applications
During this presentation, we will compare strategies for immune humanization of NSG variants to support translatable preclinical immunology, and oncology research. researchers a powerful tool for cha
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NSG-FLT3-IL15: A More Comprehensive Immune Humanized Model for Natural Killer Cells
In this presentation, we introduce The Jackson Laboratory’s most comprehensive immune humanized mouse platform to date: NSG- FLT3-IL15.
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Cancer immunotherapy: getting a little help from ourselves
We review strategies and mouse models used to develop highly promising therapeutic treatments using the body’s own immune system in the fight against cancer.
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SITC 2023 Comparison of Blinatumomab and Biosimilar CD19xCD3 BiTE responses in PBMC-Humanized Mice Used as a Preclinical Lymphoma Mouse Mode
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De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)
In this webinar, we discuss the humanized FcRn platform, an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules.
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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages
In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.
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PEGS EU 2023 - Predicting the Clinical PK of Candidate Therapeutic Antibodies
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2023 AALAS P403 Comparing tumor erosion rate following P16MC38 subcutaneous (SC) vs. mammary fat pad (MFP) injections
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2023 AALAS P402 Evaluating sub-renal capsule cavity tumor growth in immunodeficient NSG-MHC I/II double knock-out mice
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Immunomodulatory Profile
Bispecifics and CAR-T sequences
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Of Mice and Men - FcRn Biology and it's Implications in a Therapeutic Perspective
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The Next Generation of Humanized Mice for Translational Research - Dr. Michael Brehm
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Humanized Mice: FcRn Biology
Simone Mester, PhD, Authera Biotech, speaking at The Jackson Laboratory EU Symposium. Of Mice and Men - FcRn biology and its implications in a therapeutic perspective.
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Humanized Mice: Hematopoietic Stem Cells and Antibody-Mediated Depletion
Frank Lehmann, PhD, Cimeio Therapeutics, speaking at The Jackson Laboratory EU Symposium. Molecular shielding protects hematopoietic stem cells from antibody-mediated depletion.
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Humanized Mice: Next Generation Mesenchymal Cell Therapy: From CAR-T to COVID-19
Tomer Bronshtein, PhD speaking at The Jackson Laboratory EU Symposium. Preclinical to clinical development of next-generation mesenchymal cell therapy: from CAR-T induced CRS in humanized models to re
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CRS Highlights for EU Symposium
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