Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models
Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.
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Immuno-Oncology/Oncology
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Enhanced Development of Human Innate Immunity in Humanized Mice
Learn about JAX's enhanced innate immune models: the CD34+ engrafted NSG-FLT3 and NSG-FLT3-IL15 mice, presented by Michael Brehm, Ph.D., UMass Medical School.
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Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research
During this webinar, we will discuss the most widely used immunodeficient mouse models and important considerations for selecting the most appropriate model.
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JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice
In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.
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Comparing Immune-Humanized Mouse Platforms for Preclinical Applications
During this presentation, we will compare strategies for immune humanization of NSG variants to support translatable preclinical immunology, and oncology research. researchers a powerful tool for cha
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NSG-FLT3-IL15: A More Comprehensive Immune Humanized Model for Natural Killer Cells
In this presentation, we introduce The Jackson Laboratory’s most comprehensive immune humanized mouse platform to date: NSG- FLT3-IL15.
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Cancer immunotherapy: getting a little help from ourselves
We review strategies and mouse models used to develop highly promising therapeutic treatments using the body’s own immune system in the fight against cancer.
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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages
In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.
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The Promise of Cancer Genomics
Learn about the advantages of using genomic-based strategies in the fight against cancer
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Exploring Cancer Research: Tools and Technologies
Find out which tools and technologies are used by scientists to advance the field of cancer research, including sequencing, cell-based models of cancer, and mouse models of cancer.
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Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics
Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.
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A Novel In Vivo Model to Simultaneously Assess Efficacy and Toxicity of Chimeric Antigen Receptor T-Cell Immunotherapy
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Exploring Cancer: Biology and Inheritance
Discover the fundamental properties of cancer cells and explore the genetic basis, inheritance, risk factors and prevention of this disease.
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Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer
The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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Predictive Pre Clinical Oncology Studies Using Patient-Derived Xenograft Platforms
This on-demand webinar provides strategies for using PDX models in predictive preclinical research and an introduction to PDX models for immuno-oncology research.
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How To Make Your New NSG Variant in a Fraction of the Time
CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies
This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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Designing Your In Vivo Studies
September 9, 2021 - Learn about unique experimental design considerations and critically important topics that affect the reproducibility of your In Vivo research studies.
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JAX Tech Talk Episode 48: Developing Immunotherapies with Hu-NSG-MHC I/II DKO Mice (Jan. 11, 2022)
January 11, 2022 - In this episode, we will discuss using PBMC humanized NSG-MHC I/II DKO mice in preclinical research to develop and assess efficacy of human immuno-therapeutics.
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Introduction to In Vivo Platforms for Cancer Immunotherapy
Grace Berryhill, Ph.D. provides an overview of in vivo platforms being used to improve the translational relevance of cancer immunotherapies.
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