April 13, 2021 - In today’s episode, we will discuss the latest developments in oncology research which were shared during the April 7, 2021 JAX Scientific Session. We invite you to join our discussio
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For the first time ever, drug developers have the option to accurately assess immunotoxicity and drug efficacy in the same study utilizing a novel humanized platform.
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The NSG Humanized Mouse platform is an efficient way to test bispecific antibodies, including CD3 binding bispecific. This case study highlights our recent data.
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The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.
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Assessing novel therapeutics that function to modulate the interaction between the human immune system and cancer cells requires advanced preclinical efficacy testing platforms. Immunologically...
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In this episode, we will be discussing what PDX models are, why they are considered more translatable, and examples of preclinical cancer studies conducted at JAX.
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Abstract When time isn’t on anyone’s side, how can clinicians and patients make the most educated decision for their treatment? Implementation of next-generation sequencing to uncover the...
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Join Rick Huntress and Natalie Hurlen, Ph.D. on Wednesday, August 12 as they discuss humanizing immunodeficient mice. Learn more here: https://resources.jax.org/jax-blog/working-with-humanized-nsg-mic
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Join Rick Huntress and Aaron Rose, Ph.D. today as they discuss the ways that JAX can support custom humanization projects, including the NBSGW or NSG-Kit (026622). Learn More at: https://www.jax.org/j
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The term “humanized” mouse can mean many things to many people, but we’ll define it as a mouse that harbors engrafted human tissue or cells, such as immune cells. Here are some helpful tips.
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Join Drs. Kyle Draheim and Dr. Jenny Morgenweck today as they give a preview of our upcoming Immunology scientific sessions on Monday, July 20.
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Watch this video to learn the process of generating and characterizing “humanized” NSG™ (Hu-NSG™) mice and view data demonstrating preclinical research applications of these novel mouse models.
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When people think of innovation, often times they think of new products like iPhones and companies like SpaceX. But innovation spans far beyond what one may typically think of and can be applied...
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Join Grace Berryhill, Ph.D. and Andrew Schile, Ph.D. as they discuss the considerations in choosing an immunodeficent mouse model. Learn more at: JAX.org/Immunodeficient-Models-YT
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Immunodeficient mice are invaluable tools for immunology, infectious disease, oncology, hematopoietic, and regenerative medicine studies. They can serve as hosts for engraftment of mouse tumor...
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Basile Siewe, Ph.D. and Li-Chin (Lily) Yao, Ph.D., discuss cancer immunotherapies and specifically the role of NK cells in developing these therapies.
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Searching for data JAX provides researchers free access to the Mouse Tumor Biology (MTB) database, a continuously updated repository of tumor biology data. MTB supports the use of mice as a model...
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