Cancer immunotherapy: getting a little help from ourselves
We review strategies and mouse models used to develop highly promising therapeutic treatments using the body’s own immune system in the fight against cancer.
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Immuno-Oncology/Oncology
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Comparing Immune-Humanized Mouse Platforms for Preclinical Applications
February 20, 2024 - During this presentation, we compare strategies for immune humanization of NSG variants to support translatable preclinical immunology and oncology research.
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Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research
January 16, 2024 - In this webinar, we discuss the most widely used immunodeficient mouse models and essential considerations for selecting the most appropriate model.
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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages
In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.
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The Promise of Cancer Genomics
Learn about the advantages of using genomic-based strategies in the fight against cancer
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Exploring Cancer Research: Tools and Technologies
Find out which tools and technologies are used by scientists to advance the field of cancer research, including sequencing, cell-based models of cancer, and mouse models of cancer.
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Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics
Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.
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JAX Clinical Knowledgebase - Identify Resistance Variants in Preclinical Drug Testing
One of the major challenges oncologists are often faced with when managing precision cancer treatment is acquired drug resistance.
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Making a Case for Preclinical Data - The JAX Clinical Knowledgebase
The JAX Clinical Knowledgebase (CKB) is a relational database that contains data associated with cancer variants, tumor types, and therapies.
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A Novel In Vivo Model to Simultaneously Assess Efficacy and Toxicity of Chimeric Antigen Receptor T-Cell Immunotherapy
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Exploring Cancer: Biology and Inheritance
Discover the fundamental properties of cancer cells and explore the genetic basis, inheritance, risk factors and prevention of this disease.
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Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer
The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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Predictive Pre Clinical Oncology Studies Using Patient-Derived Xenograft Platforms
This on-demand webinar provides strategies for using PDX models in predictive preclinical research and an introduction to PDX models for immuno-oncology research.
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How To Make Your New NSG Variant in a Fraction of the Time
CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies
This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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Designing Your In Vivo Studies
September 9, 2021 - Learn about unique experimental design considerations and critically important topics that affect the reproducibility of your In Vivo research studies.
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JAX Tech Talk Episode 48: Developing Immunotherapies with Hu-NSG-MHC I/II DKO Mice (Jan. 11, 2022)
January 11, 2022 - In this episode, we will discuss using PBMC humanized NSG-MHC I/II DKO mice in preclinical research to develop and assess efficacy of human immuno-therapeutics.
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JAX Tech Talk Episode 47: Let’s Talk Navigating the JAX Clinical Knowledgebase (Dec. 14, 2021)
oin us as we talk with a JAX-CKB curator about what goes into the knowledgebase.
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Introduction to In Vivo Platforms for Cancer Immunotherapy
Grace Berryhill, Ph.D. provides an overview of in vivo platforms being used to improve the translational relevance of cancer immunotherapies.
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Human KIT+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma
Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.
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