The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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This on-demand webinar provides strategies for using PDX models in predictive preclinical research and an introduction to PDX models for immuno-oncology research.
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CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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September 9, 2021 - Learn about unique experimental design considerations and critically important topics that affect the reproducibility of your In Vivo research studies.
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January 11, 2022 - In this episode, we will discuss using PBMC humanized NSG-MHC I/II DKO mice in preclinical research to develop and assess efficacy of human immuno-therapeutics.
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(recording date: 3/04/2021) Grace Berryhill, Ph.D. provides an overview of in vivo platforms being used to improve the translational relevance of cancer immunotherapies. Covered in this webinar are:
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Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.
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September 14, 2021 - In this episode, we discuss how the xenogeneic GvHD model in NSG mice aligns with your drug development pipeline.
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An example of study information provided when conducting a GvHD study with the Jackson Laboratory. This example shows Bispecific Antibodies in comparison with Abatacept.
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Aug. 24, 2021 - In this episode, we apply the concepts of Cre-lox technology to control spatial and temporal gene expression and allow you to expand the types of questions you can answer in oncology.
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The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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Basile Siewe, Ph.D. and Li-Chin (Lily) Yao, Ph.D., discuss cancer immunotherapies and specifically the role of NK cells in developing these therapies.
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Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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Modeling chimeric antigen receptor (CARS) and T cell bispecific (TCB) therapies in mice
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Dr. Jan Eckmann, Group Leader Oncology Discovery Pharmacology at Roche, presents The Use of Humanized Mice in Antibody Drug Discovery as part of The Jackson Laboratory's Antibody Drug Development Summ
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Dr. James Keck, Senior Director, Innovation and Product Development, The Jackson Laboratory, presents De-risking Therapeutic Antibody Preclinical Drug Development: Simultaneous Assessment of Efficacy
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Dr. Danyig Cai, Associate Director, Innovation & Product Development, The Jackson Laboratory, presents An In Vivo PBMC Humanized Mouse Model for Determining Immunotherapy Related Cytokine Release Synd
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Frederic Thalheimer, Ph.D. Talk title: Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors
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Craft the ideal model with JAX's Model Generation Services to design and produce the genetically modified mouse model that is precisely what you need for your research.
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