The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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Frederic Thalheimer, Ph.D. Talk title: Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors
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Craft the ideal model with JAX's Model Generation Services to design and produce the genetically modified mouse model that is precisely what you need for your research.
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April 13, 2021 - In today’s episode, we will discuss the latest developments in oncology research which were shared during the April 7, 2021 JAX Scientific Session. We invite you to join our discussio
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Immunomodulatory Induced Cytokine Release; What In Vivo Tells You That In Vitro Cannot
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Talk Title: A Tour of Humanized Mouse Models for Immunotherapy Efficacy Studies
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Talk Title: Are Young Mice the Right Tool for Evaluation of Immunotherapeutics? Aged C57Bl/6J Mice for Syngeneic Studies
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The JAX CRS assay has a highly flexible design applicable to a wide variety of human specific immune modulatory therapies. The assay can test both immunostimulatory and immunosuppressive therapies.
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At The Jackson Laboratory (JAX), we are working with our customers to test CAR T efficacy in solid and disseminated tumors and investigate new models of efficacy and safety testing of this nascent the
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For the first time ever, drug developers have the option to accurately assess immunotoxicity and drug efficacy in the same study utilizing a novel humanized platform.
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The NSG Humanized Mouse platform is an efficient way to test bispecific antibodies, including CD3 binding bispecific. This case study highlights our recent data.
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The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.
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Assessing novel therapeutics that function to modulate the interaction between the human immune system and cancer cells requires advanced preclinical efficacy testing platforms. Immunologically...
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In this episode, we will be discussing what PDX models are, why they are considered more translatable, and examples of preclinical cancer studies conducted at JAX.
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Abstract When time isn’t on anyone’s side, how can clinicians and patients make the most educated decision for their treatment? Implementation of next-generation sequencing to uncover the...
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During this episode, we share recommendations from our JAX clinical veterinary team on caring for immunodeficient mice.
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Join Rick Huntress and Natalie Hurlen, Ph.D. on Wednesday, August 12 as they discuss humanizing immunodeficient mice. Learn more here: https://resources.jax.org/jax-blog/working-with-humanized-nsg-mic
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