Julia is a woman in her early 20s establishing care in your practice. During the course of your conversation, she tells you that she recently did an at-home ancestry test and was surprised when...
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All that glitters… Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor T-cells, promoting their own...
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Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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Using patient-derived xenograft (PDX) mice enables modeling the heterogeneity of human cancer and conducting more translationally-relevant cancer research studies.
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Studying cancer cell development, including signaling pathways and other types of cell-cell communications between immune cells and tumors, is critical to generating and evaluating...
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Watch this video to learn about cutting edge preclinical mouse platforms used to evaluate immuno-modulatory therapies for human cancer.
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We’ve all heard the famous Ben Franklin quote, “if you fail to plan, you are planning to fail,” and any researcher knows, he was right. Planning is an essential part of any study: you plan for...
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The JAX Clinical Knowledgebase (CKB) is a valuable resource that can be utilized to interpret somatic variants and identify the most relevant therapy via efficacy evidence annotations. Here is a...
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What is in a name? From mouse strain nomenclature, you can determine genetic background, genetic modifications, who created the strain and who currently distributes it.
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In today's economic climate, research funding and vivarium space are becoming increasingly limited. As a result, investigators are challenged with managing their mouse colonies more efficiently.
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The revolutionary NOD scid gamma (NSG™) mouse model is used by investigators worldwide to advance research in cancer, infectious diseases and a wide array of immunological disorders.
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Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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This video reviews mouse reproductive biology, focusing on optimizing the breeding productivity of research mouse colonies.
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Aging studies are lengthy, resource intensive, and require advance planning. Learn special considerations for maximizing the translational value of data collected from aged research mice.
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