A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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With JAX Humanized Mice you can support multiple therapeutic approaches and leverage different components of the human immune system at the same time. This means getting to your research milestones faster and with more accurate data. Read our latest content to learn more about our solutions.
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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Modeling chimeric antigen receptor (CARS) and T cell bispecific (TCB) therapies in mice
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Dr. Jan Eckmann, Group Leader Oncology Discovery Pharmacology at Roche, presents The Use of Humanized Mice in Antibody Drug Discovery as part of The Jackson Laboratory's Antibody Drug Development Summ
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The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.
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Michael Brehm, University of Massachusetts Medical School Title: Transgenic expression of human IL15 in NOD-scid IL2rgnullmice enhances the development and survival of functional human NK cells
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Alba Matas Céspedes, Astra Zeneca Title: Use of human splenocytes in an innovative humanized mouse model for prediction of immunotherapy-inducedcytokine release syndrome
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Sebastian Theobald, Hannover Medical School Title: Modeling human cytomegalovirus infections in humanized mice for preclinical development of novel cellular and antibody-based therapies
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You may have noticed that the latest biomedical breakthroughs are utilizing more and more humanized mice. But, what is a humanized mouse and why would scientists want to utilize this type of...
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July 14, 2020 - In this episode, we cover the remaining murine immunity, the lack of engraftment of certain lineages, and what can be done about the lack of antigen-specific responses.
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July 21, 2020 - In this episode, we’ll highlight incredible new approaches to induce immune-mediated killing of tumors using mice with humanized immune systems.
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Frequently Asked Questions about CD34+ HSC Humanized Mice Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in...
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Assessing novel therapeutics that function to modulate the interaction between the human immune system and cancer cells requires advanced preclinical efficacy testing platforms. Immunologically...
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Watch this video to learn the process of generating and characterizing “humanized” NSG™ (Hu-NSG™) mice and view data demonstrating preclinical research applications of these novel mouse models.
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The NSG Humanized Mouse platform is an efficient way to test bispecific antibodies, including CD3 binding bispecific. This case study highlights our recent data.
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