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Humanized Mice
2022 AACR POSTER: Enhanced Development Of Functional Human Innate Immune Cells In A Novel FLT3NullNSG Mouse Strain Expressing Human FLT3L

2022 AACR POSTER: Enhanced Development Of Functional Human Innate Immune Cells In A Novel FLT3NullNSG Mouse Strain Expressing Human FLT3L

Published Date March 31, 2022

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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies

This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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A MHC Class I & II Deficient Platform Humanized with PBMCs

JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.

Other content in this Stream

about 1 month ago
JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice

In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.

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2 months ago
Humanized Mice for the Assessment of the Safety of Immunotherapies

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2 months ago
Next-Generation Humanized Models for the Preclinical Development of Therapeutic Antibodies

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2 months ago
Using the HuPK™ Platform to Predict the PK of Candidate Therapeutic Antibodies

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2 months ago
New Directions for Therapeutic Antibody Formats: An Overview of Development Trends and the Current Clinical Pipeline

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about 1 year ago
HuPK: A Humanized Platform for therapeutic antibody PK evaluation

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3 months ago
Comparing Immune-Humanized Mouse Platforms for Preclinical Applications

During this presentation, we will compare strategies for immune humanization of NSG variants to support translatable preclinical immunology, and oncology research. researchers a powerful tool for cha

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3 months ago
NSG-FLT3-IL15: A More Comprehensive Immune Humanized Model for Natural Killer Cells

In this presentation, we introduce The Jackson Laboratory’s most comprehensive immune humanized mouse platform to date: NSG- FLT3-IL15.

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5 months ago
JAX Humanized Mice PubCast: IBD, Tregs, IL-2 + NSG mice

Learn about an immune humanized model of irritable bowel disease (IBD) used to investigate the mechanism of action and evaluate the therapeutic efficacy of interleukin-2 in treating ulcerative colitis

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7 months ago
Biologics Drug Development Gets an Upgrade with Humanized Animal Models

JAX Study Director Aaron Rose, Ph.D., explores how biological therapeutics are reshaping the drug development process and why humanized models are essential for advancing biologics programs.

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8 months ago
JAX Humanized Mice PubCast: CD19-CD28 Bispecific + FcRn mouse model to predict human PK

In this PubCast, we delve into Roche’s integration of humanized mice in their preclinical drug development pipeline to assess the safety and efficacy of their CD19-CD28 bispecific.

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9 months ago
JAX Humanized Mice PubCast: Mast cells & Anti-PD-1 Therapy (Apr. 3, 2024)

Join us as we discuss a collaborative effort between academia and a biopharmaceutical company, which utilized humanized mice to explore the role of mast cells in the melanoma tumor microenvironment.

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10 months ago
JAX Humanized Mice PubCast: HIV-1 in Humanized Mice (Mar. 14, 2024)

In this PubCast, we discuss a study from Yale University that employed humanized PBMC-NSG mice to model HIV and test the efficacy of two novel long-acting antiretroviral delivery systems. Resource

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12 months ago
Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research

January 16, 2024 - In this webinar, we discuss the most widely used immunodeficient mouse models and essential considerations for selecting the most appropriate model.

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about 1 year ago
Translatable Efficacy & Safety Testing of mAb, Bispecific, & CAR T Therapies

During this webinar, we discuss preclinical data showcasing efficacy and safety testing of immunotherapies in immune humanized mouse models.

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about 1 year ago
De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)

In this webinar, we discuss the humanized FcRn platform, an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules.

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about 1 year ago
New Immune-humanized Models Support More Diverse Human Immune Cell Lineages

In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.

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about 1 year ago
Rapid In Vivo Evaluation of Immuno-Modulatory Therapies Using Hu-PBMC NSG™ Mice

Learn about Hu-PBMC NSG models that can be used to test the efficacy of human T cell immunomodulatory therapeutics for graft-versus-host disease (GvHD), autoimmune disorders, and cancer.

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about 2 years ago
Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics

Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.

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about 2 years ago
DROSHA but not DICER is Required for Human Haematopoietic Stem Cell Function

Using lentiviral shRNA constructs, this presentation demonstrates that DROSHA, but not DICER, is required for the differentiation of human HSCs after engraftment into immunodeficient NSG-SGM3 mice.

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