Humanized mice are powerful tools for modeling complex immune cell interactions and functions. The Humanized Mice PubCast was created to illustrate the incredible breadth of applications for these platforms by looking at examples from the published literature. Explore our podcast series, where JAX scientists discuss peer-reviewed publications from various fields that utilize immune humanized mice.
In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.
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Learn about an immune humanized model of irritable bowel disease (IBD) used to investigate the mechanism of action and evaluate the therapeutic efficacy of interleukin-2 in treating ulcerative colitis
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In this PubCast, we delve into Roche’s integration of humanized mice in their preclinical drug development pipeline to assess the safety and efficacy of their CD19-CD28 bispecific.
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Join us as we discuss a collaborative effort between academia and a biopharmaceutical company, which utilized humanized mice to explore the role of mast cells in the melanoma tumor microenvironment.
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In this PubCast, we discuss a study from Yale University that employed humanized PBMC-NSG mice to model HIV and test the efficacy of two novel long-acting antiretroviral delivery systems. Resource
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