June 28, 2022 - In this episode, we chat about making mouse models with large transgene inserts comparing different methodologies, and introducing Bxb1 integrase.
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CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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November 16, 2021 - In this episode, we discuss methods and considerations for generating your translationally-relevant humanized mice.
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Craft the ideal model with JAX's Model Generation Services to design and produce the genetically modified mouse model that is precisely what you need for your research.
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The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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Join us this week for a conversation on Model Generation. We'll cover the basics on what it is, what types of models JAX can generate, critical factors in developing the right model for you, and much
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Join is on Wednesday, September 9 for a follow up discussion about Model Generation. We will dive a little deeper into model generation, look into layering mutations, B6 to NODs, and more! For more in
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September 15, 2020 - In this episode, we discuss how to streamline mouse model generation.
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Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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In the beginning Thirty-four years ago, Richard Palmiter of the University of Washington and Ralph Brinster of the University of Pennsylvania created the world’s first transgenic mouse that,...
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The trouble with ROS Approximately 6 million people worldwide suffer from primary inherited immunodeficiency diseases which pose a life-long challenge for those affected by them (Bousfiha et al.,...
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Learn how to best use Cre-lox gene editing technology to genetically engineer general, tissue specific and inducible knockouts, apply the FLP-FRT system and turn on fluorescent reporter genes.
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Whether you’re developing a novel inhibitor or determining whether a gene variant is a disease-driver, you might need a mouse model that doesn’t exist yet. CRISPR technology allows you to generate...
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Check out this video for experience-based insights that can help you make decisions during your model development process.
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Watch this video to understand the potential of CRISPR/Cas to accelerate your research.
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