JAX Tech Talk Episode 67: Let’s Talk Considerations for Using Cre-lox to Generate Complex New Models (Aug. 22, 2023)
Watch this JAX Tech Talk to obtain expert guidance on using Cre-lox technology to develop your new model.
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Model Generation Services
Explore the latest JAX resources around Model Generation.
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Model Generation Services
Our team of subject matter experts will design your new mouse model based on your research goals.
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Introduction to Genetic Engineering
Learn the basics of three genetic engineering techniques that generate genetically modified mice used in biomedical research.
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JAX Tech Talk Episode 56: Let’s Talk Making Mouse Models with Large Transgenes (Jun. 28, 2022)
June 28, 2022 - In this episode, we chat about making mouse models with large transgene inserts comparing different methodologies, and introducing Bxb1 integrase.
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How To Make Your New NSG Variant in a Fraction of the Time
CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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JAX Tech Talk Episode 46: Let's Talk Genetic Humanization Using CRISPR/Cas9 (Nov. 16, 2021)
November 16, 2021 - In this episode, we discuss methods and considerations for generating your translationally-relevant humanized mice.
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Crafting a Precise Genetic Mouse Model with JAX
Craft the ideal model with JAX's Model Generation Services to design and produce the genetically modified mouse model that is precisely what you need for your research.
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Important Considerations for Generating Genetic Humanized Mouse Models
The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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JAXLive! Model Generation Part 1: An Introduction
Join us this week for a conversation on Model Generation. We'll cover the basics on what it is, what types of models JAX can generate, critical factors in developing the right model for you, and much
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Model Generation Part 2: Building Complex Models and Embracing Genetic Diversity
Join is on Wednesday, September 9 for a follow up discussion about Model Generation. We will dive a little deeper into model generation, look into layering mutations, B6 to NODs, and more! For more in
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MiceTech Talk Episode 18: Let's Talk Knockin Mouse Models (Sept. 15, 2020)
September 15, 2020 - In this episode, we discuss how to streamline mouse model generation.
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CRISPR/Cas9 Explained
Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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Zygote Editing of a NOD Mouse to Better Understand the Mechanism of Diabetes
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In the fight over the CRISPR patent, JAX customers win
In the beginning Thirty-four years ago, Richard Palmiter of the University of Washington and Ralph Brinster of the University of Pennsylvania created the world’s first transgenic mouse that,...
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Proficiency with Larger Knockins
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CRISPR delivers a crisp, new model for Chronic Granulomatous Disease
The trouble with ROS Approximately 6 million people worldwide suffer from primary inherited immunodeficiency diseases which pose a life-long challenge for those affected by them (Bousfiha et al.,...
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Cre-lox Technology in Mouse Modeling
Learn how to best use Cre-lox gene editing technology to genetically engineer general, tissue specific and inducible knockouts, apply the FLP-FRT system and turn on fluorescent reporter genes.
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Life After CRISPR – Steps to Take After Creating a New Mutant Mouse
Whether you’re developing a novel inhibitor or determining whether a gene variant is a disease-driver, you might need a mouse model that doesn’t exist yet. CRISPR technology allows you to generate...
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Mouse Model Generation: From Idea to Data
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Generating Better Mouse Models for Your Research: Approaches and Considerations
Check out this video for experience-based insights that can help you make decisions during your model development process.
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