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Model Generation Services
Zygote Editing of a NOD Mouse to Better Understand the Mechanism of Diabetes

Zygote Editing of a NOD Mouse to Better Understand the Mechanism of Diabetes

Published Date March 24, 2020

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CRISPR/Cas9 Explained

Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.
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In the fight over the CRISPR patent, JAX customers win

In the beginning Thirty-four years ago, Richard Palmiter of the University of Washington and Ralph Brinster of the University of Pennsylvania created the world’s first transgenic mouse that,...

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about 2 months ago
Using Cre-lox Technology in Mouse Modeling

In this webinar, we discuss cre-lox technology, a widely used and sophisticated tool to create general knockouts, conditional knockouts, and reporter strains.

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8 months ago
JAX Tech Talk Episode 67: Let’s Talk Considerations for Using Cre-lox to Generate Complex New Models (Aug. 22, 2023)

Watch this JAX Tech Talk to obtain expert guidance on using Cre-lox technology to develop your new model.

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over 1 year ago
Model Generation Services

Our team of subject matter experts will design your new mouse model based on your research goals.

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Introduction to Genetic Engineering

Learn the basics of three genetic engineering techniques that generate genetically modified mice used in biomedical research.

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almost 2 years ago
JAX Tech Talk Episode 56: Let’s Talk Making Mouse Models with Large Transgenes (Jun. 28, 2022)

June 28, 2022 - In this episode, we chat about making mouse models with large transgene inserts comparing different methodologies, and introducing Bxb1 integrase.

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about 2 years ago
How To Make Your New NSG Variant in a Fraction of the Time

CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...

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over 2 years ago
JAX Tech Talk Episode 46: Let's Talk Genetic Humanization Using CRISPR/Cas9 (Nov. 16, 2021)

November 16, 2021 - In this episode, we discuss methods and considerations for generating your translationally-relevant humanized mice.

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almost 3 years ago
Crafting a Precise Genetic Mouse Model with JAX

Craft the ideal model with JAX's Model Generation Services to design and produce the genetically modified mouse model that is precisely what you need for your research.

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over 2 years ago
Important Considerations for Generating Genetic Humanized Mouse Models

The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev

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over 3 years ago
JAXLive! Model Generation Part 1: An Introduction

Join us this week for a conversation on Model Generation. We'll cover the basics on what it is, what types of models JAX can generate, critical factors in developing the right model for you, and much

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over 3 years ago
Model Generation Part 2: Building Complex Models and Embracing Genetic Diversity

Join is on Wednesday, September 9 for a follow up discussion about Model Generation. We will dive a little deeper into model generation, look into layering mutations, B6 to NODs, and more! For more in

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over 3 years ago
MiceTech Talk Episode 18: Let's Talk Knockin Mouse Models (Sept. 15, 2020)

September 15, 2020 - In this episode, we discuss how to streamline mouse model generation.

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about 4 years ago
CRISPR/Cas9 Explained

Did you know that CRISPR engineering can sometimes yield more than the allele you originally intended? Learn more about mosaicism, how to resolve it, and other CRISPR basics in this video.

Watch Video
over 7 years ago
In the fight over the CRISPR patent, JAX customers win

In the beginning Thirty-four years ago, Richard Palmiter of the University of Washington and Ralph Brinster of the University of Pennsylvania created the world’s first transgenic mouse that,...

Learn More
about 4 years ago
Proficiency with Larger Knockins

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almost 7 years ago
CRISPR delivers a crisp, new model for Chronic Granulomatous Disease

The trouble with ROS Approximately 6 million people worldwide suffer from primary inherited immunodeficiency diseases which pose a life-long challenge for those affected by them (Bousfiha et...

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Cre-lox Technology in Mouse Modeling

Learn how to best use Cre-lox gene editing technology to genetically engineer general, tissue specific and inducible knockouts, apply the FLP-FRT system and turn on fluorescent reporter genes.

Learn More
about 7 years ago
Life After CRISPR – Steps to Take After Creating a New Mutant Mouse

Whether you’re developing a novel inhibitor or determining whether a gene variant is a disease-driver, you might need a mouse model that doesn’t exist yet. CRISPR technology allows you to generate...

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about 4 years ago
Mouse Model Generation: From Idea to Data

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almost 4 years ago
Generating Better Mouse Models for Your Research: Approaches and Considerations

Check out this video for experience-based insights that can help you make decisions during your model development process.

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