MODEL-AD: Creating new mouse models for late-onset Alzheimer’s disease
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Neurocognitive Resources
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MiceTech Talk Episode 22: Let’s Talk Exploring Neurobiology Solutions (Oct. 27, 2020)
October 27, 2020 - In this episode, we share with you highlights of JAX preclinical research studies using mouse models for ALS, Rett Syndrome, Friedreich's Ataxia, and more!
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MiceTech Talk Episode 12: Let's Talk Latest Advances in Alzheimer's Disease Research (Aug. 4, 2020)
August 4, 2020 - We highlight some of the latest studies and discoveries presented at the AAIC Conference, the most influential international meeting dedicated to advancing dementia science.
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Moving beyond amyloid to treat Alzheimer's disease
Beta-amyloid peptid. The amyloid precursor protein being cleaved by gamma and beta secretases and releasing the amyloid beta peptide, which can accumulate to amyloid plaques, one of the main...
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Booklet Neurobiology
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Neurobiology Services
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The Versatile Mouse Model for Rare Disease Research
More than 7,000 rare (or orphan) diseases have been described so far and affect over 350 million people worldwide. Unfortunately, less than 10% of these diseases have an approved treatment, and...
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600 trillion synapses and Alzheimers disease
Late-onset Alzheimer’s disease is extremely difficult to model in the laboratory, one reason why no successful therapy for it exists. But scientists are using new capabilities to create more...
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Investigating Stroke Therapeutic Targets Using JAX Aged C57BL/6J Mice
Introduction The brain is a highly complex organ comprised of a large number of cells and molecules, each with its own unique function. Diseases that affect the central nervous system (CNS), such...
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Can I Outrun Alzheimer's Disease?
This is the third in a series about my genome sequence. I’ve already posted about my general thoughts and a conversation with a genetic counselor. Below I focus on the ApoE4 gene, the one...
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Alzheimer's disease and the complex puzzle of degeneration
Alzheimer’s disease is frightening. Incurable, progressive, burdensome and still biologically mysterious, it afflicts primarily the elderly and inexorably degenerates the brain tissue of patients....
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