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Watch this webinar for guidance on the informed selection of in vivo mouse models for the preclinical evaluation of therapeutic candidates for Alzheimer’s disease.
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Watch this webinar to learn how to select appropriate combinations of Cre drivers and loxP-flanked alleles for tissue-specific effects.
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In this webinar, we’ll cover the basics of iPSCs, showcase real-world research applications, and discuss the biological questions these models help answer.
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Automated platform to generate high-quality induced iPSC lines and differentiate them into diverse, disease-relevant cell types. Advanced capabilities for efficient, reproducible research.
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What You'll Learn:PBMC models enable in vivo human immune system studiesDelayed GvHD supports longer, more flexible study windowsNSG-S15-DKO shows:Enhanced multi-lineage engraftment (T, NK,...
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Learn about the S15‑DKO strain (NSG-NSG‑MHC I/II DKO × NSG‑SGM3‑IL15), which supports broader human immune cell engraftment (T, B/plasma, NK, cDC, macrophages, γδ T cells) without acute xGvHD.
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Learn how the Behavioral Phenotyping Core at Seattle Children’s Research Institute expanded its capabilities with the integration of the Allentown Discovery IVC Rack powered by The Jackson Laboratory.
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Learn more about the JAX-NYSCF partnership to accelerate cures for the major diseases of our time through stem cell research, from large iPSC cohorts for specific disease areas to developing...
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IntroductionNatural killer (NK) cells occupy an intriguing niche between adaptive and innate immunity. Like cytotoxic T lymphocytes, they can recognize and kill infected or malignant cells and...
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View highlights and comparison of JAX genetically engineered isogenic iPSC and donor-derived, disease-specific iPSC lines.
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Watch this webinar to learn how different mouse models capture different facets of human metabolic disease.
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This webinar explores how to accelerate therapeutic antibody discovery by improving the quality and diversity of in vivo starting candidates using modern transgenic mouse platforms.
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In a previous post I discussed breeding Cre/lox mice to generate tissue-specific and inducible conditional knockout mouse strains. I would now like to continue the discussion of breeding Cre/lox...
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Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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Many commercial and academic researchers have access to a vivarium and have not seriously considered using outside resources. Rising model complexity, tighter budgets, and shrinking vivarium...
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Introduction: The History of “Hallmarks” in Biological ResearchLife science researchers worldwide are familiar with the publication series “The Hallmarks of Cancer”, initially laid out by Hanahan...
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Learn about JAX's collection of workhorse strains for tracking cells in adoptive transfer experiments, immunologically important cellular subsets, MHC Class I, II, and TCR-specific responses, & more.
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