Exome Testing For Diagnosis
Watch this video for an overview of the clinical indications for exome testing, associated benefits, risks and limitations, and interpreting results.
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Latest Content
Welcome to our Hub! We hope you find something interesting to read, watch and share.
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Mouse Genetic Diversity: Translating Discoveries to Humans
This MiniCourse introduces core concepts of genetically diverse mouse models and their applicability for common translational research studies.
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Evidence-based selection of the starting dose in first-in-human clinical trials using humanized mouse models
The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...
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Predictive Pre Clinical Oncology Studies Using Patient-Derived Xenograft Platforms
This on-demand webinar provides strategies for using PDX models in predictive preclinical research and an introduction to PDX models for immuno-oncology research.
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JAX Tech Talk Episode 54: Let's talk HET3 Mice Used to Test Anti-Aging Compounds (Apr. 19, 2022)
April 19, 2022 - Is your team involved in aging studies? In this episode, we dive into the advantages of aged HET3 mice from The Jackson Laboratory.
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How To Make Your New NSG Variant in a Fraction of the Time
CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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In Vivo Preclinical Efficacy & Safety of CAR-T, -NK, and -Myeloid Based Therapies
Technical Information Services Manager, Brian Soper, Ph.D., explores recent advances in CAR mediated strategies for human immuno-oncology. Recorded on 4-7-22
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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies
Introduction Since the first chimeric antigen receptor (CAR) T cell therapy received FDA approval in 2017, this promising immunotherapy modality has only continued to gather momentum. Existing CAR...
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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies
This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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New Fellowship at JAX to Unravel the Complexities Between Aging and Cancer
It’s been long recognized that aging is the single biggest risk factor for cancer and that age impacts treatment response. Research is urgently needed to develop a mechanistic understanding of the...
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JAX Tech Talk Episode 53: Let's Talk Fighting Cancer with CAR-based Therapies (Apr. 5, 2022)
April 5, 2022 - In the battle to fight cancer, one ingenious approach being pursued is chimeric antigen receptor (CAR) -based therapies. As cancer cells look to shut off the cytotoxic activity of anti
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A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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Preclinical Drug Development Fact Sheet
A glimpse at the wide range of platforms and services JAX offers to help move you from drug discovery to IND filing.
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CRS Studies for CAR T Cell Therapy
Review JAX’s CRS evaluation capabilities and see how a CRS study can help move your CAR T therapeutic into the clinic faster, safer, and more confidently.
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Poster: TGN1412-Induced Cytokine Release Syndrome and Pathological Evaluation in a Humanized PBMC Mouse Model
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JAX Tech Talk Episode 52: Let's Talk JAX Consulting & Advisory Services (Mar. 15, 2022)
March 15, 2022 - Is your team looking for more detailed and personalized support? In this episode, we will dive into all that our JAX Consulting and Advisory Services can offer your research program.
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JAX Tech Talk Episode 51: Let’s Talk Accelerating Research with JAX’s GvHD Platform (Mar. 1, 2022)
March 1, 2022 - In this episode, the JAX Tech Talk Team welcomes Prabir Banerjee to discuss the JAX GvHD platform and its value in accelerating your preclinical research studies.
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A translationally-relevant alternative to non-human primates
Just last week, the Food and Drug Administration (FDA) published recommendations to drug developers and researchers urging them to consider alternatives to non-human primates (NHPs) in general...
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Designing Your In Vivo Studies
September 9, 2021 - Learn about unique experimental design considerations and critically important topics that affect the reproducibility of your In Vivo research studies.
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JAX Tech Talk Episode 50: Let’s Talk Accelerating Development of CAR T Therapies (Feb. 15, 2022)
February 15, 2022 - With new advances being unraveled in the world of CAR T therapies, Team JAX Tech Talk discusses the latest advancements JAX has developed to support drug developers in the field.
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Studying Complex, Systemic Immune Responses in Humanized Mice
Although many mammals have immune systems that share important characteristics with humans, certain immune cell types and phenomena are unique to us. As a result, it has been difficult to design...
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