GvHD Efficacy Study Fact Sheet
An example of study information provided when conducting a GvHD study with the Jackson Laboratory. This example shows Bispecific Antibodies in comparison with Abatacept.
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Latest Content
Welcome to our Hub! We hope you find something interesting to read, watch and share.
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Underrepresented, underserved and understudied
Frustrated about lack of actionable results in genetic testing Donna is a 60-year-old Black woman with a personal history of breast cancer, diagnosed at age 49. Her oncologist recommended she...
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Diversity Mice User Guide
This user guide is designed to introduce you to the core concepts of genetic diversity, present diversity models, and their key features.
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Important Considerations for Generating Genetic Humanized Mouse Models
The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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JAX Tech Talk Episode 42-Let's Talk Oncology Solutions Using Advanced Cre-Lox Technology-24Aug2021
Aug. 24, 2021 - Some cancer-driver mutations you might be studying could cause unintended illness or lethality if expressed too early in development or in too many tissues. In this episode, we will ap
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JAX Tech Talk, Episode 41: Let’s Talk Cre-Lox for Neuroscientists - 10Aug2021
Aug. 10, 2021 - Defining, manipulating, and controlling the spatial and temporal expression of genes is critical for understanding the complex genetic architecture of the nervous system. In this epis
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JAX Metabolism & Type 2 Diabetes In Vivo Services
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JAX Metabolism & Type 2 Diabetes In Vivo Services
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Kids at risk? When parents should consider hereditary cancer testing for their children.
If you’ve been following our blog or participating in our courses (learn.education.jax.org), you’ll know that there are many hereditary cancer syndromes that increase adults’ lifetime cancer...
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Old Age and Diet Together in Mice Represent a Unique Model of Human NASH
Aged C57BL/6J mice represent a new dietary model for nonalcoholic steatohepatitis (NASH) that accounts for the known risk factor of age in the human disease.
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Understanding Natural Killer Cells in Cancer Immunotherapies
Basile Siewe, Ph.D. and Li-Chin (Lily) Yao, Ph.D., discuss cancer immunotherapies and specifically the role of NK cells in developing these therapies.
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Wearables, clinical data and COVID-19
Like one in five Americans, I wear a watch that also tracks several health-related statistics through the day. It tells me how well I slept, how many steps I took, how high my heart rate got...
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JAX Tech Talk, Episode 40: Let’s Talk Aligning Mice Generation with Preclinical Studies (20Jul2021)
July 20, 2021 - Having the right number and genotype of mice, just when you need them, can be as challenging as designing the perfect research or drug efficacy study itself. In today’s episode, we wi
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Genetically Diverse Mouse Models for Every Stage of the Research Pipeline
Mouse research is often performed in genetically-defined inbred mouse strains, where each mouse within a strain is virtually identical to one another.
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JAX Tech Talk, Episode 39: Let's Talk JAX Swiss Outbred Mice (29-Jun-2021)
June 29, 2021 - In this episode, we will discuss the new JAX Swiss Outbred mouse model also known as J:ARC. We will talk about how this strain is maintained using the Poiley method of rotational non-s
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JAX Antibody Development Summit - Jan Eckmann
Dr. Jan Eckmann, Group Leader Oncology Discovery Pharmacology at Roche, presents The Use of Humanized Mice in Antibody Drug Discovery as part of The Jackson Laboratory's Antibody Drug Development Summ
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JAX Antibody Development Summit - James Keck
Dr. James Keck, Senior Director, Innovation and Product Development, The Jackson Laboratory, presents De-risking Therapeutic Antibody Preclinical Drug Development: Simultaneous Assessment of Efficacy
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JAX Antibody Development Summit - Delphine Valente
Dr. Delphine Valente, Head of Pharmacokinetics at Sanofi, presents Humanized FcRn Mice: a Promising Tool for Evaluating the Pharmacokinetics of Engineered Monoclonal and Multi Specific Antibodies as p
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JAX Antibody Development Summit - Jan Terje Andersen
Dr. Jan Terje Andersen, Professor, University of Oslo, presents FcRn as a Target for Engineering of Albumin-Based Biologics with Favorable In Vivo Properties as part of The Jackson Laboratory's Antibo
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JAX Antibody Development Summit - Geoff Hale
Dr. Geoff Hale, CEO, mAbsolve, presents Characterisation of Novel Antibodies Which are Completely Silenced with Respect to Fc Binding Function as part of The Jackson Laboratory's Antibody Drug Develo
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