A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
Read Flipbook
Latest Content
Welcome to our Hub! We hope you find something interesting to read, watch and share.
-
-
immunomodulatory profile
Bispecifics and CAR-T sequences
Watch Video
-
JAX Tech Talk Episode 67: Let’s Talk Considerations for Using Cre-lox to Generate Complex New Models (Aug. 22, 2023)
Watch this JAX Tech Talk to obtain expert guidance on using Cre-lox technology to develop your new model.
Watch Video
-
Essential Tips for Choosing and Using Mouse Models in Research
Learn about finding and selecting mouse models, the basics of mouse nomenclature, the importance of choosing the appropriate controls for your experiment, and how genetic drift affects your colony.
Watch Video
-
JAX Tech Talk Episode 66: Let’s Talk J:ARC Swiss Outbred Mouse Model (Jul. 20, 2023)
Join us as we revisit the J:ARC Swiss Outbred model, a well-known outbred mouse model with numerous research applications, ranging from toxicity studies to recipient dams for in vitro fertilization.
Watch Video
-
JAX Tech Talk Episode 65: Let’s Talk Tools to Consider after Generating a New Mouse Model (Jul. 11, 2023)
JAX technical information scientists Neeraj Tiwari and Peter Kelmenson discuss JAX research services including model selection, model generation and breeding.
Watch Video
-
In Vivo Platforms for Autoimmune Pharmacology: MS-EAE Capabilities
Watch this webinar to learn about Experimental Autoimmune Encephalomyelitis (EAE), which serves as the gold standard preclinical model for MS research.
Watch Video
-
JAX Tech Talk Episode 64: Let’s Talk HET3 Mice - A Genetically Diverse Model to Study Mammalian Aging (Jun. 6, 2023)
In this episode, we discuss considerations for working with HET3 mice, a comparison of HET3 to other models, and how this model is used to identify agents that extend lifespan and health span in mice.
Watch Video
-
The Complexity of Rare Disease
Learn about the complexity of rare disease and the unique difficulty it presents to patients and families by exploring the patient journey—from diagnosis to research to drug development.
Learn More
-
CD34+ Humanized Mice
Human cord blood-derived hematopoietic CD34+ stem cells. Validated: greater than 25% human CD45+ cells in peripheral blood. Humanized NSG variants (hu-CD34+). Infectious disease, gene therapy, cancer,
Watch Video
-
CAR T studies with significantly delayed onset of GvHD
Assessing efficacy and toxicity in CAR-T studies in an accessible translational model. The Jackson Laboratory's in vivo PBMC-humanized mouse platform provides a wider window to look at cytokine releas
Watch Video
-
CAR T-induced Immunotoxicity: Tackling the Cytokine Release Syndrome Challenge
In this special joint webinar, we discuss CAR T-induced Immunotoxicity, highlighting cutting-edge platforms for assessing the safety and efficacy of CAR therapies and preventing the development of CRS
Watch Video
-
Evidence-Based Selection of the Starting Dose in First-in-Human Clinical Trials Using Humanized Mouse Models
Read Flipbook
-
Neurofilament Light Chain Tech Sheet
Read Flipbook
-
Exploring Rare Disease Through Translational Research
Learn how mouse models help researchers disentangle the complexity of rare disease and help drive preclinical drug development.
Learn More
-
JAX Tech Talk Episode 63: Let's talk FcRn: The Translational Platform for Antibody PK Assessment (Apr. 25, 2023)
Learn the benefits of using the FcRn mouse model platform in characterizing the PK of your therapeutic, from the long half-life to the types of antibody therapeutics that can be screened.
Watch Video
-
Using the Hu-PK Platform to Predict the PK of Candidate Therapeutic Antibodies
Read Flipbook
-
Type1 Diabetes Efficacy Studies Tech Sheet
Read Flipbook
-
Lupus Efficacy Studies Tech Sheet
Read Flipbook
-
Psoriasis Efficacy Studies Tech Sheet
Read Flipbook
-
Loading More...
