HuPK: A Humanized Platform for therapeutic antibody PK evaluation
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Latest Content
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Key Considerations to Optimize Preclinical Aging Studies
During this webinar, we discuss how mouse phenotypes change over time, review study design considerations, and share several examples of using aged C57BL/6J mice in preclinical studies.
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Utility Of Case Reports And JAX-CKB In Mitigating The Challenge Of Treating Patients With EGFR EXON 20 Insertions In Non-small Cell Lung Can
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JAX Tech Talk Episode 68: Let’s Talk iPSC Disease Models as a Tool in Drug Discovery (Nov. 7, 2023)
During this JAX Tech Talk, Dr. Steven Rodriguez, Lab Head of the Rare & Neurological Diseases Therapeutic Area at Sanofi, discusses how his group uses iPSC models to understand disease biology.
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CKB FAQ 2023
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Preclinical Neurobiology Services Booklet
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SITC 2023 Comparison of Blinatumomab and Biosimilar CD19xCD3 BiTE responses in PBMC-Humanized Mice Used as a Preclinical Lymphoma Mouse Mode
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SITC 2023 PBMC Humanized Mouse Model with Clinical Relevance in Assessing the Safety Profile of 4-1BB Agonist, Urelumab, in 5 Donors
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2022 AALAS P31 Practicing the 3R's
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De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)
In this webinar, we discuss the humanized FcRn platform, an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules.
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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages
In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.
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Aged HET3 Mice Postcard
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They're More than Mice They're J Mice
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Rapid In Vivo Evaluation of Immuno-Modulatory Therapies Using Hu-PBMC NSG™ Mice
Learn about the characteristics of PBMC-humanized mice that enable the testing of novel therapeutics for immune suppression or immune activation across multiple genetically diverse donors.
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JAX Resources for the Management of Transgenic Mice
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CD34+ Hu-NSG-SGM3-IL15 Tech Sheet
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CD34+ Hu-NSG-FLT3 Tech Sheet
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Comparing Mouse Models for Obesity and Diabetes Research
Watch this webinar to learn about the strengths and weaknesses of popular mouse models of human type 2 diabetes and obesity. webinar to learn about: • The benefits and limitations of some common
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The Many Faces of C57BL/6 Mice: Research Impact of B6 Substrain Differences
In this webinar, we cover the considerations for choosing and using the most appropriate B6 substrain for your research needs.
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A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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