A New Way to Study Cytokine Release Syndrome
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Welcome to our Hub! We hope you find something interesting to read, watch and share.
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Assessing patient health risks with limited or unknown family history
With November designated as Family Health History month, clinicians are sure to have seen lots of messaging encouraging their patients to discuss family health history around the Thanksgiving...
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JAX Tech Talk Episode 45: Let's Talk Pre-Cannulated Mice & Other Surgical Services (Oct. 19, 2021)
October 19, 2021 - Many research and preclinical programs require surgically modified mice. JAX Surgical Services provide a fast and easy way to obtain study-ready mice when needed. In this episode, w
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JAX Tech Talk Episode 44: Let's Talk Grants for Genetic Background’s Impact on Translatability (Oct. 5, 2021)
October 5, 2021 - Is your treatment robust enough to "work" in different genetic backgrounds? Are your preclinical studies assessing translatability? In this episode, we will explore: how J:DO mice m
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A Humanized Preclinical in Vivo System to Predict the Immunotoxicity of Antibody Drug Candidates
James Keck, Ph.D., Senior Director, Innovation and Product Development, at JAX speaks about a humanized preclinical in vivo system to predict the the immunotoxicity of antibody drug candidates.
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Testing the Efficacy of Immuno-Modulatory Antibodies in Humanized Mice
Aaron Rose, Ph.D., Senior Study Director, In Vivo Services, The Jackson Laboratory speaks about testing the efficacy of immunomodulatory antibodies in humanized mice.
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The Humanized FcRn Platform: An Essential Tool for Preclinical PK Assessment of Therapeutic Antibody Candidates
Greg Christianson, Study Director, In Vivo Services, The Jackson Laboratory speaks about the use of human FcRn transgenic mouse models to select antibody therapeutic candidates with optimum pharmacoki
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Human Immune System Engrafted Mice and Their Role in Human Antibody-Based Drug Development
Brian Soper, Ph.D., Senior Manager, Technical Information Services, The Jackson Laboratory speaks about human immune system engrafted mice and their role in human antibody-based drug development.
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Human KIT+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma
Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.
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JAX Tech Talk Episode 43: Let’s Talk Assessing Efficacy of GvHD Therapeutics (Sept. 14, 2021)
September 14, 2021 - In this episode, we discuss how the xenogeneic GvHD model in NSG mice aligns with your drug development pipeline.
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GvHD Efficacy Study Fact Sheet
An example of study information provided when conducting a GvHD study with the Jackson Laboratory. This example shows Bispecific Antibodies in comparison with Abatacept.
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Underrepresented, underserved and understudied
Frustrated about lack of actionable results in genetic testing Donna is a 60-year-old Black woman with a personal history of breast cancer, diagnosed at age 49. Her oncologist recommended she...
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Diversity Mice User Guide
This user guide is designed to introduce you to the core concepts of genetic diversity, present diversity models, and their key features.
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Important Considerations for Generating Genetic Humanized Mouse Models
The term humanization is used, to much confusion, to mean several different things in mouse research. While broad in scope and technique, all humanized mouse models share a common goal – to better lev
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JAX Tech Talk Episode 42: Let's Talk Oncology Solutions Using Advanced Cre-Lox Technology (Aug. 24, 2021)
Aug. 24, 2021 - In this episode, we apply the concepts of Cre-lox technology to control spatial and temporal gene expression and allow you to expand the types of questions you can answer in oncology.
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JAX Tech Talk Episode 41: Let’s Talk Cre-Lox for Neuroscientists (Aug. 10, 2021)
Aug. 10, 2021 - In this episode, we will explore the use of Cre-lox technology to control gene expression in neuronal cell types, and more.
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JAX Metabolism & Type 2 Diabetes In Vivo Services
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JAX Metabolism & Type 2 Diabetes In Vivo Services
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Kids at risk? When parents should consider hereditary cancer testing for their children.
If you’ve been following our blog or participating in our courses (learn.education.jax.org), you’ll know that there are many hereditary cancer syndromes that increase adults’ lifetime cancer...
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Old Age and Diet Together in Mice Represent a Unique Model of Human NASH
Aged C57BL/6J mice represent a new dietary model for nonalcoholic steatohepatitis (NASH) that accounts for the known risk factor of age in the human disease.
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Understanding Natural Killer Cells in Cancer Immunotherapies
Basile Siewe, Ph.D. and Li-Chin (Lily) Yao, Ph.D., discuss cancer immunotherapies and specifically the role of NK cells in developing these therapies.
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