Guide to Using Cre-lox Technology to Generate Tissue-Specific Modifications
Watch this webinar to learn how to select appropriate combinations of Cre drivers and loxP-flanked alleles for tissue-specific effects.
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Driving Better Therapeutic Antibodies with Next Generation Mouse Models
This webinar explores how to accelerate therapeutic antibody discovery by improving the quality and diversity of in vivo starting candidates using modern transgenic mouse platforms.
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Cre Lox Breeding for Beginners, Part 2
In a previous post I discussed breeding Cre/lox mice to generate tissue-specific and inducible conditional knockout mouse strains. I would now like to continue the discussion of breeding Cre/lox...
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Cre Lox Breeding for Beginners, Part 1
Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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Insourcing or Outsourcing your Breeding Projects: Considerations and Advice for Making this Critical Decision
Many commercial and academic researchers have access to a vivarium and have not seriously considered using outside resources. Rising model complexity, tighter budgets, and shrinking vivarium...
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The Hallmarks of Aging – Key Mechanisms and Models in Neurobiology
Introduction: The History of “Hallmarks” in Biological ResearchLife science researchers worldwide are familiar with the publication series “The Hallmarks of Cancer”, initially laid out by Hanahan...
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Novel Mouse Models for Cancer Research
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The Immunologist’s Toolbox: Workhorse Strains in the JAX Repository
Learn about JAX's collection of workhorse strains for tracking cells in adoptive transfer experiments, immunologically important cellular subsets, MHC Class I, II, and TCR-specific responses, & more.
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Robust Engraftment of Human γδ T Cells in Humanized NSG-SGM3-IL-15 x MHC I/II Double Knockout Mice For the Evaluation of γδ T Cell-based The
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Improved humanization of peripheral blood mononuclear cells in NSG-SGM3xIL15xDKO (S15-DKO) over that of NSG-MHC I/II DKO mice for immune-onc
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Age-related transcriptional and alternative splicing changes in lung progenitor cells predisposing to immune dysfunction
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Phone-based Portable Slide Digitization System for AI-Enabled Histopathology
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Inducing memory humoral responses using multiple vaccines in PBMC humanized mice
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Establishment of patient-derived lung epithelial progenitor lines as a foundation for autologous immune and tumor modeling
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In vivo Lentiviral CAR-T Gene Delivery Demonstrates High Specificity and Potent anti-Tumor Activity in a Humanized B Cell Lymphoma Model
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In Vivo Evaluation of Autologous Anti-BCMA CAR-T Therapy in PBMC-humanized S15-DKO Mice Reveals Donor-specific Immune Responses
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A novel NSG-SGM3xIL15xDKO-based PBMC humanized mouse model to evaluate efficacy and cytokine release of immunotherapies
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Why Single Measures Fail: The Case for Systems-Based Analysis in Animal Research
Researchers have long relied on single measures and univariate analytical approaches to evaluate animal health, physiology, and behavior as proxies for complex biological states. While clearly...
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From Awareness to Action in Experimental Design
Animal physiological and behavioral research is subject to many confounding influences that can be difficult to control, potentially compromising experimental findings. Without proper experimental...
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Exploring Biologics to Drive NK Cell Immunotherapy in Mouse Models of Human Cancer
Learn how mouse models, using different formats of human natural killer (NK) cells and human cancer cells, can be leveraged to evaluate the efficacy of biologics to amplify tumor control.
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