Exome Testing For Diagnosis
Watch this video for an overview of the clinical indications for exome testing, associated benefits, risks and limitations, and interpreting results.
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Learn. Engage. Connect.
Watch this video for an overview of the clinical indications for exome testing, associated benefits, risks and limitations, and interpreting results.
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Immunomodulatory therapies are the latest weapon to be added to the cancer-fighting arsenal. These therapies work by generating or augmenting the immune response to a tumor. Discovering and validating
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But wait, didn’t the Human Genome Project accomplish that feat about 20 years ago? The simple answer is no, it did not. The first “complete” human genome sequence was actually complete only in...
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July 26, 2022 - In this episode, we consider methods to reduce bias in order to increase the translatability of your results to the clinic.
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As colleges and universities, research institutes and other organizations continue to create more high-quality online courses, these digital badges are becoming a common way for successful...
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June 28, 2022 - In this episode, we chat about making mouse models with large transgene inserts comparing different methodologies, and introducing Bxb1 integrase.
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JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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For over 90 years JAX has been helping researchers reliably and cost-effectively mitigate risk by preserving strains through our reproductive services.
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This video explores Onco-Hu® models, a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells. The platform is based on NSG™ and NSG™-SGM3 tr
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The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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In this webinar, we discuss upcoming and established strains in the JAX COVID-19 Model Portfolio, in the context of in vivo findings with SARS-CoV2 and related viruses.
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This discussion focuses on preclinical efficacy and safety testing for novel antibody-based therapeutics.
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The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...
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This on-demand webinar provides strategies for using PDX models in predictive preclinical research and an introduction to PDX models for immuno-oncology research.
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April 19, 2022 - Is your team involved in aging studies? In this episode, we dive into the advantages of aged HET3 mice from The Jackson Laboratory.
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CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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Technical Information Services Manager, Brian Soper, Ph.D., explores recent advances in CAR mediated strategies for human immuno-oncology. Recorded on 4-7-22
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Introduction Since the first chimeric antigen receptor (CAR) T cell therapy received FDA approval in 2017, this promising immunotherapy modality has only continued to gather momentum. Existing...
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This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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