An Introduction to iPSCs: Applications, Models, and Best Practices
In this webinar, we’ll cover the basics of iPSCs, showcase real-world research applications, and discuss the biological questions these models help answer.
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Latest Content
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The JAX-NYSCF Global Stem Cell Array®️
Automated platform to generate high-quality induced iPSC lines and differentiate them into diverse, disease-relevant cell types. Advanced capabilities for efficient, reproducible research.
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An Advanced PBMC-Humanized NSG-S15-DKO Mouse Model for Comprehensive Evaluation of Immunotherapeutics
What You'll Learn:PBMC models enable in vivo human immune system studiesDelayed GvHD supports longer, more flexible study windowsNSG-S15-DKO shows:Enhanced multi-lineage engraftment (T, NK,...
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S15-DKO: New Platform for Engraftment of Human PBMC Supporting Multilineage Immune Cells, Low GvHD
Learn about the S15‑DKO strain (NSG-NSG‑MHC I/II DKO × NSG‑SGM3‑IL15), which supports broader human immune cell engraftment (T, B/plasma, NK, cDC, macrophages, γδ T cells) without acute xGvHD.
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Home Sweet Home: Leveraging Continuous Home-Cage Monitoring to Improve Science and Animal Welfare
Learn how the Behavioral Phenotyping Core at Seattle Children’s Research Institute expanded its capabilities with the integration of the Allentown Discovery IVC Rack powered by The Jackson Laboratory.
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Partner with JAX-NYSCF
Learn more about the JAX-NYSCF partnership to accelerate cures for the major diseases of our time through stem cell research, from large iPSC cohorts for specific disease areas to developing...
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New JAX NSG portfolio strains support development of human NK cells in oncology models
IntroductionNatural killer (NK) cells occupy an intriguing niche between adaptive and innate immunity. Like cytotoxic T lymphocytes, they can recognize and kill infected or malignant cells and...
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Powering Discovery with JAX iPSC Models
View highlights and comparison of JAX genetically engineered isogenic iPSC and donor-derived, disease-specific iPSC lines.
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Comparing Mouse Models for Metabolic Disease: Diabetes, Obesity, and MASH
Watch this webinar to learn how different mouse models capture different facets of human metabolic disease.
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Guide to Using Cre-lox Technology to Generate Tissue-Specific Modifications
Watch this webinar to learn how to select appropriate combinations of Cre drivers and loxP-flanked alleles for tissue-specific effects.
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Driving Better Therapeutic Antibodies with Next Generation Mouse Models
This webinar explores how to accelerate therapeutic antibody discovery by improving the quality and diversity of in vivo starting candidates using modern transgenic mouse platforms.
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Cre Lox Breeding for Beginners, Part 2
In a previous post I discussed breeding Cre/lox mice to generate tissue-specific and inducible conditional knockout mouse strains. I would now like to continue the discussion of breeding Cre/lox...
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Cre Lox Breeding for Beginners, Part 1
Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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Insourcing or Outsourcing your Breeding Projects: Considerations and Advice for Making this Critical Decision
Many commercial and academic researchers have access to a vivarium and have not seriously considered using outside resources. Rising model complexity, tighter budgets, and shrinking vivarium...
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The Hallmarks of Aging – Key Mechanisms and Models in Neurobiology
Introduction: The History of “Hallmarks” in Biological ResearchLife science researchers worldwide are familiar with the publication series “The Hallmarks of Cancer”, initially laid out by Hanahan...
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Novel Mouse Models for Cancer Research
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The Immunologist’s Toolbox: Workhorse Strains in the JAX Repository
Learn about JAX's collection of workhorse strains for tracking cells in adoptive transfer experiments, immunologically important cellular subsets, MHC Class I, II, and TCR-specific responses, & more.
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Robust Engraftment of Human γδ T Cells in Humanized NSG-SGM3-IL-15 x MHC I/II Double Knockout Mice For the Evaluation of γδ T Cell-based The
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Improved humanization of peripheral blood mononuclear cells in NSG-SGM3xIL15xDKO (S15-DKO) over that of NSG-MHC I/II DKO mice for immune-onc
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Age-related transcriptional and alternative splicing changes in lung progenitor cells predisposing to immune dysfunction
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