A New Way to Study Cytokine Release Syndrome
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Practicing culturally competent genomic medicine
Cultural competency is defined as the ability to understand, appreciate and interact with people from a culture or belief systems different from one’s own (American Psychological Society 2015)....
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Predictive Pre Clinical Oncology Studies Using Patient-Derived Xenograft Platforms
(recording date 03/18/2021) Grace Berryhill, Ph.D. speaks about patient-derived xenograft (PDX) mice, modeling the heterogeneity of human cancer, and conducting more translationally relevant cancer
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Introduction to In Vivo Platforms for Cancer Immunotherapy
(recording date: 3/04/2021) Grace Berryhill, Ph.D. provides an overview of in vivo platforms being used to improve the translational relevance of cancer immunotherapies. Covered in this webinar are:
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Quick Guide to Mouse Nomenclature
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How do I get from here to there? Navigating precision medicine in cancer
This scenario is more complicated than it may seem. With genomic tumor testing, a negative result is not always definitive. In some cases a genomic variant can be present but not detected by the...
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Human Immune System Engrafted Platforms for More Translatable Preclinical Research
Senior Manager and Technical Information Scientist, Brian Soper, Ph.D., discusses human immune system engrafted platforms and preclinical research.
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Study Considerations and Preclinical Testing to Study Aging
Dr. Kaitlyn Gilland, Senior Technical Information Scientist, discusses working with aged C57BL/6J mice, study considerations, and preclinical testing.
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JAX Tech Talk Episode 46: Let's Talk Genetic Humanization Using CRISPR/Cas9 (Nov. 16, 2021)
November 16, 2021 - In this episode, we discuss methods and considerations for generating your translationally-relevant humanized mice.
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Efficacy and Safety of Therapeutics in Immuno-modulatory Induced Cytokine Release Syndrome
Brian W. Soper, Ph.D. speaks about the efficacy and safety of therapeutics in immuno-modulatory induced cytokine release syndrome. Dr. Soper discusses human PBMC engraftment profiles; modeling human c
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Robust CAR-T Memory Formation and Function via Hematopoietic Stem Cell Delivery
Scott Kitchen, PH.D., Director of UCLA CFAR/JCCC Humanized Mouse Laboratory, presents at Humanized Mice Journal Club on October 26, 2021.
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Assessing patient health risks with limited or unknown family history
With November designated as Family Health History month, clinicians are sure to have seen lots of messaging encouraging their patients to discuss family health history around the holiday table....
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JAX Tech Talk Episode 45: Let's Talk Pre-Cannulated Mice & Other Surgical Services (Oct. 19, 2021)
October 19, 2021 - Many research and preclinical programs require surgically modified mice. JAX Surgical Services provide a fast and easy way to obtain study-ready mice when needed. In this episode, w
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JAX Tech Talk Episode 44: Let's Talk Grants for Genetic Background’s Impact on Translatability (Oct. 5, 2021)
October 5, 2021 - Is your treatment robust enough to "work" in different genetic backgrounds? Are your preclinical studies assessing translatability? In this episode, we will explore: how J:DO mice m
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A Humanized Preclinical in Vivo System to Predict the Immunotoxicity of Antibody Drug Candidates
James Keck, Ph.D., Senior Director, Innovation and Product Development, at JAX speaks about a humanized preclinical in vivo system to predict the the immunotoxicity of antibody drug candidates.
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Testing the Efficacy of Immuno-Modulatory Antibodies in Humanized Mice
Aaron Rose, Ph.D., Senior Study Director, In Vivo Services, The Jackson Laboratory speaks about testing the efficacy of immunomodulatory antibodies in humanized mice.
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The Humanized FcRn Platform: An Essential Tool for Preclinical PK Assessment of Therapeutic Antibody Candidates
Greg Christianson, Study Director, In Vivo Services, The Jackson Laboratory speaks about the use of human FcRn transgenic mouse models to select antibody therapeutic candidates with optimum pharmacoki
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Human Immune System Engrafted Mice and Their Role in Human Antibody-Based Drug Development
Brian Soper, Ph.D., Senior Manager, Technical Information Services, The Jackson Laboratory speaks about human immune system engrafted mice and their role in human antibody-based drug development.
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Human KIT+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma
Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.
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JAX Tech Talk Episode 43: Let’s Talk Assessing Efficacy of GvHD Therapeutics (Sept. 14, 2021)
September 14, 2021 - In this episode, we discuss how the xenogeneic GvHD model in NSG mice aligns with your drug development pipeline.
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GvHD Efficacy Study Fact Sheet
An example of study information provided when conducting a GvHD study with the Jackson Laboratory. This example shows Bispecific Antibodies in comparison with Abatacept.
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