A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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Bispecifics and CAR-T sequences
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Watch this JAX Tech Talk to obtain expert guidance on using Cre-lox technology to develop your new model.
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Learn about finding and selecting mouse models, the basics of mouse nomenclature, the importance of choosing the appropriate controls for your experiment, and how genetic drift affects your colony.
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Join us as we revisit the J:ARC Swiss Outbred model, a well-known outbred mouse model with numerous research applications, ranging from toxicity studies to recipient dams for in vitro fertilization.
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JAX technical information scientists Neeraj Tiwari and Peter Kelmenson discuss JAX research services including model selection, model generation and breeding.
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Watch this webinar to learn about Experimental Autoimmune Encephalomyelitis (EAE), which serves as the gold standard preclinical model for MS research.
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In this episode, we discuss considerations for working with HET3 mice, a comparison of HET3 to other models, and how this model is used to identify agents that extend lifespan and health span in mice.
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Learn about the complexity of rare disease and the unique difficulty it presents to patients and families by exploring the patient journey—from diagnosis to research to drug development.
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Human cord blood-derived hematopoietic CD34+ stem cells. Validated: greater than 25% human CD45+ cells in peripheral blood. Humanized NSG variants (hu-CD34+). Infectious disease, gene therapy, cancer,
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Assessing efficacy and toxicity in CAR-T studies in an accessible translational model. The Jackson Laboratory's in vivo PBMC-humanized mouse platform provides a wider window to look at cytokine releas
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In this special joint webinar, we discuss CAR T-induced Immunotoxicity, highlighting cutting-edge platforms for assessing the safety and efficacy of CAR therapies and preventing the development of CRS
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Learn how mouse models help researchers disentangle the complexity of rare disease and help drive preclinical drug development.
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Learn the benefits of using the FcRn mouse model platform in characterizing the PK of your therapeutic, from the long half-life to the types of antibody therapeutics that can be screened.
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