Guide to Choosing the Right Cancer Research Model
This webinar provides a comprehensive, scientifically grounded overview of the diverse oncology model platforms available from The Jackson Laboratory
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Latest Content
Welcome to our Hub! We hope you find something interesting to read, watch and share.
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Tools with a Mission: Using Disease Models to Find a Treatment for PURA Syndrome
This webinar explores the urgent need for innovative models and highlights JAX’s development of iPSC lines to advance understanding of PURA syndrome and enable drug discovery.
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PDX Models
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Immune Cell Humanized Mouse Models: PBMC Engrafted Mice
Charu Gupta, Ph.D., Senior Technical Information ScientistKey PBMC Takeaways:Rapid engraftment: PBMCs engraft in 2-3 days with mature, human-protein expressing T cells.Human-relevant modeling:...
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Immune Cell Humanized Mice: CD34+ Hematopoietic Stem Cell Engrafted Mice
Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...
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Supporting Reproducibility & the 3R’s with Effective Mouse Colony Management
In this webinar, we share advice on maintaining mouse colonies that align with the 3Rs principles: replacement, reduction, and refinement.
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Short Course on Experimental Models of Human Cancer
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Cre Lox Breeding for Beginners, Part 1
Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...
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6 facts you should know about Nnt, C57BL/6J and diabetes
The NntC57BL/6J mutation in the nicotinamide (NAD) nucleotide transhydrogenase (Nnt) gene is found exclusively in B6/J-derived mice and has not been detected in any other B6 substrains, including...
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Navigating Mouse Nomenclature and Genetic Drift: Best Practices for Research Integrity
This webinar provides key information about mouse strain nomenclature and genetic drift in the context of supporting research integrity.
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MorPhiC: Decoding Human Protein-Coding Gene Function at Scale in iPSC-Derived Multicellular Systems
Learn about the MorPhiC Consortium and its initiative to generate a comprehensive catalog of molecular and cellular phenotypes for null alleles of every human protein-coding gene.
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AACR A new tumor-bearing humanized mouse model to evaluate the efficacy of bispecific T cell engager and monoclonal checkpoint antibodies
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Redefining Preclinical Gene Delivery Testing: Humanized Mouse Models as an Ethical and Effective Alternative to NHPs
As gene therapy continues to revolutionize modern medicine, the demand for reliable, translational, and ethically sound preclinical models has never been higher. In vivo gene delivery systems,...
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Cryopreservation of Transgenic Mice: Protect Valuable Mouse Strains and Reduce Costs
Cryopreservation is a powerful tool for colony management, protecting strains from loss while ensuring they remain available upon demand and at the scale needed (see IVF Speed Expansion...
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Aged NASH Tech Spec Sheet
This document highlights the key differences between aged and young C57BL/6J mice when it comes to NASH.
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Efficient Mouse Colony Management: FAQs on JAX’s Cryopreservation, Cryorecovery, and Breeding Services
At The Jackson Laboratory (JAX), cryopreservation is a cornerstone of our research and colony management strategy. With decades of experience, we have optimized our cryopreservation protocols and...
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The Consequences of Sex Bias in Preclinical Research Studies
Sam Eck, Ph.D. - Technical Information ScientistIntroduction: The Historical Context of Sex Bias In 1993, the NIH issued the Revitalization Act which for the first time required the inclusion of...
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Preclinical Therapeutic Antibody and Albumin-Conjugate Evaluation
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JAX’s Contributions to Metabolics Featured in Nature Metabolism
The Jackson Laboratory Contributes to Landmark Consensus Standards for Metabolic ResearchScientific progress depends on standardization. Just as consensus standards in genomics and metabolics...
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Mouse Breeding & Colony Management Services | Industry-Leading Care with JAX
As the industry leader in laboratory mouse breeding, care, and colony management, we know how complex—and fragile—animal research can be. Maintaining animal colonies and developing experimental...
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