A New Way to Study Cytokine Release Syndrome
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JAX Tech Talk Episode 48: Developing Immunotherapies with Hu-NSG-MHC I/II DKO Mice (Jan. 11, 2022)
January 11, 2022 - In this episode, we will discuss using PBMC humanized NSG-MHC I/II DKO mice in preclinical research to develop and assess efficacy of human immuno-therapeutics.
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Src/lck Inhibitor Dasatinib Reversibly Switches Off Cytokine Release and T Cell Cytotoxicity
Gabrielle Leclercq, Ph.D. presents findings that Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.
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JAX Tech Talk Episode 47: Let’s Talk Navigating the JAX Clinical Knowledgebase (Dec. 14, 2021)
oin us as we talk with a JAX-CKB curator about what goes into the knowledgebase.
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JAX Diversity Outbred Mice: A Genetically Diverse Mouse for a Diverse Human Population
Most traditional laboratory mouse strains were established by taking a mouse with unique characteristics and inbreeding it to produce a mouse population that is composed of virtually identical...
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History and Development of the Mouse Model System
Learn the history behind the development of the mouse as a model system for human disease through landmark experiments, classical genetics and groundbreaking discoveries.
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Genotyping Mice
Learn how to successfully run a JAX protocol to genotype your JAX mice.
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Mutant and Transgenic Mouse Strains: A Beginner's Guide
Learn how to create and use mutant and transgenic mouse strains for your research, through topics on genetic engineering, genetic background, nomenclature, selecting genetic controls and more.
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Basics of CRISPR/Cas9
Get your research started with CRISPR/Cas9 genetic engineering technology by learning about nuclease biology, somatic and germline gene editing, avoiding off-target events and more.
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Breeding Strategies: Simple to Complex
Depending on your research needs, breeding can be simple or complex. This course will help you figure out the most efficient breeding strategies for your experimental and control mice. Don't be afraid
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Cre-lox Technology in Mouse Modeling
Learn how to best use Cre-lox gene editing technology to genetically engineer general, tissue specific and inducible knockouts, apply the FLP-FRT system and turn on fluorescent reporter genes.
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Beyond Genes: Epigenetics, Environment, and Health
Gain a basic understanding of genetics versus epigenetics and learning about environmental causes and consequences of epigenetic changes in human and mouse model studies.
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Reproductive Biology of the Laboratory Mouse
Gain a basic understanding of laboratory mouse reproductive biology by examining basic anatomy, sex determination, the fertilization process, estrous cycle and more.
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Sizing Mouse Colonies: A Beginner’s Guide
Learn how to size experimental mouse colonies to accurately match your research needs in a consistent manner with a minimum use of resources!
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Mapping Complex Traits in Mice
Learn about the study of complex traits genetics in mice. Find out how inbred mouse strains and advanced mouse populations enable complex traits genetics techniques, such as QTL mapping.
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Diversity Outbred Mice
Interested in using genetically diverse mouse models as opposed to inbred strains? Learn about the Collaborative Cross (CC) & Diversity Outbred (DO) populations.
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Common Laboratory Mouse Strains: A Beginner's Guide
This MiniCourse introduces inbred, outbred, and hybrid mouse strains and explains breeding schemes, nomenclature, genetic drift, finding phenotypic information, animal health and more.
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CRS Model Platform
With The Jackson Laboratory’s novel humanized mouse models for CRS, you can test for both, immunotoxicity, and drug efficacy at the same time. You can test candidate therapies, with or without the pre
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Strategies for Creating Complex Breeding Schemes
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Q&A: Studying Cytokine Release Syndrome in a Diverse Population
Our immune system is incredibly complex and powerful—sometimes almost too powerful. Occasionally, it responds to a disease or drug with an inflammatory overreaction known as cytokine release...
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Practicing culturally competent genomic medicine
Cultural competency is defined as the ability to understand, appreciate and interact with people from a culture or belief systems different from one’s own (American Psychological Society 2015)....
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