Exome Testing For Diagnosis
Watch this video for an overview of the clinical indications for exome testing, associated benefits, risks and limitations, and interpreting results.
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Latest Content
Welcome to our Hub! We hope you find something interesting to read, watch and share.
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The New Era For In Vivo Immunotherapy Testing Is Here
Immunomodulatory therapies are the latest weapon to be added to the cancer-fighting arsenal. These therapies work by generating or augmenting the immune response to a tumor. Discovering and validating
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Progress with long read sequencing
But wait, didn’t the Human Genome Project accomplish that feat about 20 years ago? The simple answer is no, it did not. The first “complete” human genome sequence was actually complete only in...
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JAX Tech Talk Episode 57: Let’s Talk Reducing Bias in Mouse Studies (Jul. 26, 2022)
July 26, 2022 - In this episode, we consider methods to reduce bias in order to increase the translatability of your results to the clinic.
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Acute Myeloid Leukemia: Patient-Derived Xenograft Models
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What are digital badges and why should you consider sharing yours?
As colleges and universities, research institutes and other organizations continue to create more high-quality online courses, these digital badges are becoming a common way for successful...
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JAX Tech Talk Episode 56: Let’s Talk Making Mouse Models with Large Transgenes (Jun. 28, 2022)
June 28, 2022 - In this episode, we chat about making mouse models with large transgene inserts comparing different methodologies, and introducing Bxb1 integrase.
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A MHC Class I & II Deficient Platform Humanized with PBMCs
JAX NSG-MHC I/II KO mice readily engraft tumors and human PBMCs, have delayed GvHD, and deliver translationally-relevant results for various research applications.
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Disaster Preparedness
For over 90 years JAX has been helping researchers reliably and cost-effectively mitigate risk by preserving strains through our reproductive services.
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Onco-Hu® Mouse Models
This video explores Onco-Hu® models, a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells. The platform is based on NSG™ and NSG™-SGM3 tr
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Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer
The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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Cancer Genetic Testing Process (CNE)
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Mouse Models of Coronavirus Infection
In this webinar, we discuss upcoming and established strains in the JAX COVID-19 Model Portfolio, in the context of in vivo findings with SARS-CoV2 and related viruses.
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JAX Tech Episode 55: Let’s Talk of Mice and Monkeys (May 17, 2022)
This discussion focuses on preclinical efficacy and safety testing for novel antibody-based therapeutics.
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Evidence-based selection of the starting dose in first-in-human clinical trials using humanized mouse models
The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...
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Predictive Pre Clinical Oncology Studies Using Patient-Derived Xenograft Platforms
This on-demand webinar provides strategies for using PDX models in predictive preclinical research and an introduction to PDX models for immuno-oncology research.
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JAX Tech Talk Episode 54: Let's talk HET3 Mice Used to Test Anti-Aging Compounds (Apr. 19, 2022)
April 19, 2022 - Is your team involved in aging studies? In this episode, we dive into the advantages of aged HET3 mice from The Jackson Laboratory.
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How To Make Your New NSG Variant in a Fraction of the Time
CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...
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In Vivo Preclinical Efficacy & Safety of CAR-T, -NK, and -Myeloid Based Therapies
Technical Information Services Manager, Brian Soper, Ph.D., explores recent advances in CAR mediated strategies for human immuno-oncology. Recorded on 4-7-22
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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies
Introduction Since the first chimeric antigen receptor (CAR) T cell therapy received FDA approval in 2017, this promising immunotherapy modality has only continued to gather momentum. Existing...
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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies
This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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