The Jackson Laboratory

Biology's Complexity Creates Problems We Can't Ignore

Science depends on reproducibility, yet getting consistent results in biological systems can often be challenging. The inherent complexity of these systems makes it difficult to observe...

Breeding Better: Strategies for Increasing Reproductive Performance in Laboratory Mice

Are you experiencing suboptimal breeding performance in your mouse colonies? Navigating mouse husbandry requires specialized knowledge. In this article we offer expert, JAX-approved guidance, in...

The Hallmarks of Cancer – a Celebration of the 2026 Edition

Introduction: The History of “The Hallmarks of Cancer”Cancer researchers around the world are familiar with the landmark publication “The Hallmarks of Cancer,” initially set out by Hanahan and...

Immune Cell Humanized Mouse Models: PBMC Engrafted Mice

Charu Gupta, Ph.D., Senior Technical Information ScientistKey PBMC Takeaways:Rapid engraftment: PBMCs engraft in 2-3 days with mature, human-protein expressing T cells.Human-relevant modeling:...

Immune Cell Humanized Mice: CD34+ Hematopoietic Stem Cell Engrafted Mice

Charu Gupta, Ph.D., Senior Technical Information Scientist Key Takeaways:Diverse and Functional Immune Populations: HSC engraftment supports maturation of both adaptive and innate immune...

Short Course on Experimental Models of Human Cancer

Cre Lox Breeding for Beginners, Part 1

Simply put, the Cre/lox system rocks. It is one of the most powerful tools in the mouse geneticist’s toolbox. Why? Well, it enables them to generate tissue-specific and inducible knockouts and...