HuPK Highlights for EU Symposium
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JAX presented in a European tour in 4 cities to demonstrate how the immunotherapy pipeline can benefit from the expertise of JAX, a major player in the in vivo preclinical pharmacology space. We are discussing why humanized mice are becoming the golden standard for preclinical immunotherapy development.
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The FcRn platform from The Jackson Laboratory mimics specific aspects of the human IgG physiology providing the ideal model platform to assess the pharmacokinetics (PK) of therapeutic antibody candida
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The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...
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This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.
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Review JAX’s CRS evaluation capabilities and see how a CRS study can help move your CAR T therapeutic into the clinic faster, safer, and more confidently.
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Greg Christianson, Study Director, In Vivo Services, The Jackson Laboratory speaks about the use of human FcRn transgenic mouse models to select antibody therapeutic candidates with optimum pharmacoki
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The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.
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CD34 and PBMC humanized NSG mice are powerful preclinical models for studying the actions of immuno-modulators, either alone or in combination with other treatments.
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