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The Jackson Laboratory's EU Symposium

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Advances and Applications of Humanized In Vivo Models in Preclinical Drug Development
Use of FcRn Transgenic mice for drug discovery of therapeutic antibodies with Roche's Michael Otteneder, PhD

Use of FcRn Transgenic mice for drug discovery of therapeutic antibodies with Roche's Michael Otteneder, PhD

Published Date October 21, 2020

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FcRn model platform

The FcRn platform from The Jackson Laboratory mimics specific aspects of the human IgG physiology providing the ideal model platform to assess the pharmacokinetics (PK) of therapeutic antibody candida
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Evidence-based selection of the starting dose in first-in-human clinical trials using humanized mouse models

The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...

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Humanized Mice Highlights for EU Symposium

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FcRn model platform

The FcRn platform from The Jackson Laboratory mimics specific aspects of the human IgG physiology providing the ideal model platform to assess the pharmacokinetics (PK) of therapeutic antibody candida

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about 3 years ago
Evidence-based selection of the starting dose in first-in-human clinical trials using humanized mouse models

The dose selection for first-in-human (FIH) clinical trials relies on data obtained by a combination of in vitro and in vivo studies designed to evaluate the efficacy, toxicity, and stability of...

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over 2 years ago
In Vivo Evaluation of Bispecific T-Cell Engager Efficacy and Safety

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In vivo Preclinical Efficacy & Safety of CAR-T, -NK, and -Myeloid Based Therapies

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Achieving Relevant Preclinical Characterization of CAR T Cell Therapies

This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.

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over 3 years ago
CRS Studies for CAR T Cell Therapy

Review JAX’s CRS evaluation capabilities and see how a CRS study can help move your CAR T therapeutic into the clinic faster, safer, and more confidently.

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almost 4 years ago
The Humanized FcRn Platform: An Essential Tool for Preclinical PK Assessment of Therapeutic Antibody Candidates

Greg Christianson, Study Director, In Vivo Services, The Jackson Laboratory speaks about the use of human FcRn transgenic mouse models to select antibody therapeutic candidates with optimum pharmacoki

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over 4 years ago
Targeting Natural Killer Cell Activity with Humanized NSG IL-15 Mouse Model

The NEW cord blood CD34+ HSC humanized NSG-IL15 mouse enables efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity.

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JAX Guide: Assessing Antibody Pharmacokinetics Using the JAX FcRn Platform

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Humanized NSG Mouse Models

CD34 and PBMC humanized NSG mice are powerful preclinical models for studying the actions of immuno-modulators, either alone or in combination with other treatments.

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