Skip to main content

The Jackson Laboratory

Home

Recent Searches

Share this Post

Share on facebook
Share on twitter
Share on linkedin
Share on email

Home
Humanized Mice Journal Club
Keck J., The Jackson Laboratory. A new humanized model for the prediction of CRS in vivo

Keck J., The Jackson Laboratory. A new humanized model for the prediction of CRS in vivo

Published Date October 19, 2020

Fill form to unlock content

Loading, please wait

Error - something went wrong!

Access the On-Demand Video

Thank you!

Previous Video

Predicting CRS using humanized mice

Alba Matas Céspedes, Astra Zeneca Title: Use of human splenocytes in an innovative humanized mouse model for prediction of immunotherapy-inducedcytokine release syndrome
Next Video

IgG production in humanized mice

Sebastian Theobald, Hannover Medical School Title: Modeling human cytomegalovirus infections in humanized mice for preclinical development of novel cellular and antibody-based therapies

Most Recent Videos

over 1 year ago
Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics

Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.

Watch Video
over 1 year ago
Mesothelin-specific CAR-T Cell Therapy with HLA-gated Safety Mechanism Selectively Kills Tumor Cells

Leading this session, our guest speaker, Dr. Talar Tokatlian from A2 Biotherapeutics, shares information on a new dual receptor CAR T cell therapy for mesothelin-expressing solid tumors.

Watch Video
over 1 year ago
CAR T-cell Cytotoxicity of Solid Tumors is Dependent on IFNγR Signaling & Downstream Adhesion

In this session, we take a look at the relative difference in the efficacies of CAR T therapies for solid and liquid tumors and the role of IFNγR signaling in mediating their responses.

Watch Video
over 1 year ago
DROSHA but not DICER is Required for Human Haematopoietic Stem Cell Function

Using lentiviral shRNA constructs, this presentation demonstrates that DROSHA, but not DICER, is required for the differentiation of human HSCs after engraftment into immunodeficient NSG-SGM3 mice.

Watch Video
over 1 year ago
Novel Humanized Mouse Model for Assessment of Human Allogeneic Responses in Organ Transplantation

Ashwin Ajith Ph.D., a postdoctoral fellow at the Georgia Cancer Center, Augusta University, discusses using humanized mouse models to study alloimmune responsiveness between donor and recipients.

Watch Video
almost 2 years ago
Modeling Human Melanoma To Understand And Treat Resistance To Immunotherapy

Meenard Herlyn, DVM, DSc discusses the development of a variety of 3D models, from human skin equivalents to organoids, mimicking cellular interactions in normal and malignant tissues.

Watch Video
almost 2 years ago
Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer

The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm

Watch Video
about 2 years ago
A Novel Clinically Relevant Graft-Versus-Leukemia Model in Humanized Mice

Hong Zheng, M.D., Ph.D., Associate Professor of Medicine at Penn State Cancer Institute, Penn State University College of Medicine joined us to lead a discussion on a new immune-humanized mouse model.

Watch Video
about 2 years ago
T Cells Targeted to TdT Kill Leukemic Lymphoblasts While Sparing Normal Lymphocytes

Madeleine Lehander, Ph.D. Student, Woll and Jacobsen Groups, Karolinska Institute - Department of Medicine, Huddinge, Sweden leads a discussion on T cells targeted to TdT kill leukemic lymphoblasts wh

Watch Video
about 2 years ago
NOD/scid IL-2Rγnull Mice Reconstituted with Peripheral Blood Mononuclear Cells of Crohn’s Disease

Veronika Weß leads an informative discussion on the use of the immune-humanized mouse platform to explore the biological underpinnings of inflammatory bowel disease (IBD).

Watch Video
about 2 years ago
Src/lck Inhibitor Dasatinib Reversibly Switches Off Cytokine Release and T Cell Cytotoxicity

Gabrielle Leclercq, Ph.D. presents findings that Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.

Watch Video
over 2 years ago
HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2

Jeremy A. Goettel, Ph.D., Assistant Professor of Medicine at Vanderbilt University Medical Center, Division of Gastroenterology, presented the latest research demonstrating the utility of standard imm

Watch Video
over 2 years ago
Robust CAR-T Memory Formation and Function via Hematopoietic Stem Cell Delivery

Scott Kitchen, PH.D., Director of UCLA CFAR/JCCC Humanized Mouse Laboratory, presents at Humanized Mice Journal Club on October 26, 2021.

Watch Video
over 2 years ago
Human KIT+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma

Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.

Watch Video
almost 3 years ago
Modeling Chimeric Antigen Receptor (CARS) and T Cell Bispecific (TCB) Therapies in Mice

Modeling chimeric antigen receptor (CARS) and T cell bispecific (TCB) therapies in mice

Watch Video
almost 3 years ago
Combining T-cell-specific activation & in vivo gene delivery through CD3-targeted lentiviral vectors

Frederic Thalheimer, Ph.D. Talk title: Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors

Watch Video
almost 3 years ago
HuMouse models for the influence of genetic variation on the immune control of Epstein Barr

Christian Münz, Ph.D. - Professor and Co-director of the Institute of Experimental Immunology, University of Zürich, Switzerland Talk Title: Humanized mouse models for the influence of genetic variati

Watch Video
about 3 years ago
The application of humanized mouse models to study LILRB-mediated regulation of myeloid cells

Ali Roghanian, Ph.D. - University of Southampton Title: The application of humanized mouse models to study LILRB-mediated regulation of myeloid cells

Watch Video
about 3 years ago
Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors

Johannes Sam, Roche Title: Studying the Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors and Immunomodulators in Humanized Mice

Watch Video
about 3 years ago
PD1 Blockade Aggravates Epstein-Barr Virus+

Valery Volk, Hannover Medical School Title: PD1 Blockade Aggravates Epstein-Barr Virus+ Post-Transplant Lymphoproliferative Disorder In Humanized Mice Resulting In Central Nervous System Involvement a

Watch Video

Return to Home

© The Jackson Laboratory