Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics
Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.
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The Humanized Mice Journal Club meets virtually once a month and is an opportunity for fellow scientists to present their published work to peers. The presentations all span a variety of preclinical research using humanized mouse models.
Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.
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Leading this session, our guest speaker, Dr. Talar Tokatlian from A2 Biotherapeutics, shares information on a new dual receptor CAR T cell therapy for mesothelin-expressing solid tumors.
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In this session, we take a look at the relative difference in the efficacies of CAR T therapies for solid and liquid tumors and the role of IFNγR signaling in mediating their responses.
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Using lentiviral shRNA constructs, this presentation demonstrates that DROSHA, but not DICER, is required for the differentiation of human HSCs after engraftment into immunodeficient NSG-SGM3 mice.
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Ashwin Ajith Ph.D., a postdoctoral fellow at the Georgia Cancer Center, Augusta University, discusses using humanized mouse models to study alloimmune responsiveness between donor and recipients.
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Meenard Herlyn, DVM, DSc discusses the development of a variety of 3D models, from human skin equivalents to organoids, mimicking cellular interactions in normal and malignant tissues.
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The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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Hong Zheng, M.D., Ph.D., Associate Professor of Medicine at Penn State Cancer Institute, Penn State University College of Medicine joined us to lead a discussion on a new immune-humanized mouse model.
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Madeleine Lehander, Ph.D. Student, Woll and Jacobsen Groups, Karolinska Institute - Department of Medicine, Huddinge, Sweden leads a discussion on T cells targeted to TdT kill leukemic lymphoblasts wh
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Veronika Weß leads an informative discussion on the use of the immune-humanized mouse platform to explore the biological underpinnings of inflammatory bowel disease (IBD).
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Gabrielle Leclercq, Ph.D. presents findings that Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.
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Jeremy A. Goettel, Ph.D., Assistant Professor of Medicine at Vanderbilt University Medical Center, Division of Gastroenterology, presented the latest research demonstrating the utility of standard imm
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Scott Kitchen, PH.D., Director of UCLA CFAR/JCCC Humanized Mouse Laboratory, presents at Humanized Mice Journal Club on October 26, 2021.
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Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.
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Modeling chimeric antigen receptor (CARS) and T cell bispecific (TCB) therapies in mice
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Frederic Thalheimer, Ph.D. Talk title: Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors
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Christian Münz, Ph.D. - Professor and Co-director of the Institute of Experimental Immunology, University of Zürich, Switzerland Talk Title: Humanized mouse models for the influence of genetic variati
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Ali Roghanian, Ph.D. - University of Southampton Title: The application of humanized mouse models to study LILRB-mediated regulation of myeloid cells
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Johannes Sam, Roche Title: Studying the Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors and Immunomodulators in Humanized Mice
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Valery Volk, Hannover Medical School Title: PD1 Blockade Aggravates Epstein-Barr Virus+ Post-Transplant Lymphoproliferative Disorder In Humanized Mice Resulting In Central Nervous System Involvement a
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