Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics
Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.
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Humanized Mice Journal Club
The Humanized Mice Journal Club meets virtually once a month and is an opportunity for fellow scientists to present their published work to peers. The presentations all span a variety of preclinical research using humanized mouse models.
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Mesothelin-specific CAR-T Cell Therapy with HLA-gated Safety Mechanism Selectively Kills Tumor Cells
Leading this session, our guest speaker, Dr. Talar Tokatlian from A2 Biotherapeutics, shares information on a new dual receptor CAR T cell therapy for mesothelin-expressing solid tumors.
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CAR T-cell Cytotoxicity of Solid Tumors is Dependent on IFNγR Signaling & Downstream Adhesion
In this session, we take a look at the relative difference in the efficacies of CAR T therapies for solid and liquid tumors and the role of IFNγR signaling in mediating their responses.
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DROSHA but not DICER is Required for Human Haematopoietic Stem Cell Function
Using lentiviral shRNA constructs, this presentation demonstrates that DROSHA, but not DICER, is required for the differentiation of human HSCs after engraftment into immunodeficient NSG-SGM3 mice.
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Novel Humanized Mouse Model for Assessment of Human Allogeneic Responses in Organ Transplantation
Ashwin Ajith Ph.D., a postdoctoral fellow at the Georgia Cancer Center, Augusta University, discusses using humanized mouse models to study alloimmune responsiveness between donor and recipients.
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Modeling Human Melanoma To Understand And Treat Resistance To Immunotherapy
Meenard Herlyn, DVM, DSc discusses the development of a variety of 3D models, from human skin equivalents to organoids, mimicking cellular interactions in normal and malignant tissues.
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Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer
The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm
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A Novel Clinically Relevant Graft-Versus-Leukemia Model in Humanized Mice
Hong Zheng, M.D., Ph.D., Associate Professor of Medicine at Penn State Cancer Institute, Penn State University College of Medicine joined us to lead a discussion on a new immune-humanized mouse model.
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T Cells Targeted to TdT Kill Leukemic Lymphoblasts While Sparing Normal Lymphocytes
Madeleine Lehander, Ph.D. Student, Woll and Jacobsen Groups, Karolinska Institute - Department of Medicine, Huddinge, Sweden leads a discussion on T cells targeted to TdT kill leukemic lymphoblasts wh
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NOD/scid IL-2Rγnull Mice Reconstituted with Peripheral Blood Mononuclear Cells of Crohn’s Disease
Veronika Weß leads an informative discussion on the use of the immune-humanized mouse platform to explore the biological underpinnings of inflammatory bowel disease (IBD).
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Src/lck Inhibitor Dasatinib Reversibly Switches Off Cytokine Release and T Cell Cytotoxicity
Gabrielle Leclercq, Ph.D. presents findings that Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.
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HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2
Jeremy A. Goettel, Ph.D., Assistant Professor of Medicine at Vanderbilt University Medical Center, Division of Gastroenterology, presented the latest research demonstrating the utility of standard imm
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Robust CAR-T Memory Formation and Function via Hematopoietic Stem Cell Delivery
Scott Kitchen, PH.D., Director of UCLA CFAR/JCCC Humanized Mouse Laboratory, presents at Humanized Mice Journal Club on October 26, 2021.
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Human KIT+ Myeloid Cells Facilitate Visceral Metastasis By Melanoma
Chun Yu, Ph.D., Associate Research Scientist at The Jackson Laboratory speaks about Human KIT+ myeloid cells and how they facilitate visceral metastasis by melanoma.
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Modeling Chimeric Antigen Receptor (CARS) and T Cell Bispecific (TCB) Therapies in Mice
Modeling chimeric antigen receptor (CARS) and T cell bispecific (TCB) therapies in mice
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Combining T-cell-specific activation & in vivo gene delivery through CD3-targeted lentiviral vectors
Frederic Thalheimer, Ph.D. Talk title: Combining T-cell-specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors
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HuMouse models for the influence of genetic variation on the immune control of Epstein Barr
Christian Münz, Ph.D. - Professor and Co-director of the Institute of Experimental Immunology, University of Zürich, Switzerland Talk Title: Humanized mouse models for the influence of genetic variati
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The application of humanized mouse models to study LILRB-mediated regulation of myeloid cells
Ali Roghanian, Ph.D. - University of Southampton Title: The application of humanized mouse models to study LILRB-mediated regulation of myeloid cells
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Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors
Johannes Sam, Roche Title: Studying the Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors and Immunomodulators in Humanized Mice
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PD1 Blockade Aggravates Epstein-Barr Virus+
Valery Volk, Hannover Medical School Title: PD1 Blockade Aggravates Epstein-Barr Virus+ Post-Transplant Lymphoproliferative Disorder In Humanized Mice Resulting In Central Nervous System Involvement a
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