JAX Tech Talk Episode 56: Let’s Talk Making Mouse Models with Large Transgenes (Jun. 28, 2022)
June 28, 2022 - Did you know there are novel methods to generate transgenic mouse models for preclinical drug testing and human disease modeling that are quick and easy using methods other than CRISPR? In this episode, we’ll chat about making mouse models with large transgene inserts comparing different methodologies, and introducing Bxb1 integrase.
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Important Considerations for Generating Genetic Humanized Mouse Models
Efficient targeted transgenesis of large donor DNA into multiple mouse genetic backgrounds using bacteriophage Bxb1 integrase