A New Way to Study Cytokine Release Syndrome
In vivo CRS assays have the potential to simultaneously derisk and accelerate the process of bringing successful therapies to the patients who need them most.
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PEGS Europe: Protein & Antibody Engineering Summit
We invite you to explore the 2021 PEGS posters and additional antibody drug development resources from The Jackson Laboratory.
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Poster: A Humanized In Vivo System to Predict Antibody-induced Cytokine Release Syndrome
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A Humanized Preclinical in Vivo System to Predict the Immunotoxicity of Antibody Drug Candidates
James Keck, Ph.D., Senior Director, Innovation and Product Development, at JAX speaks about a humanized preclinical in vivo system to predict the the immunotoxicity of antibody drug candidates.
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CRS: FAQs
The JAX CRS assay has a highly flexible design applicable to a wide variety of human specific immune modulatory therapies. The assay can test both immunostimulatory and immunosuppressive therapies.
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Choosing the Appropriate Humanized FcRn Mouse Model to Test the Pharmacokinetics of Antibody Therapeutics
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The Humanized FcRn Platform: An Essential Tool for Preclinical PK Assessment of Therapeutic Antibody Candidates
Greg Christianson, Study Director, In Vivo Services, The Jackson Laboratory speaks about the use of human FcRn transgenic mouse models to select antibody therapeutic candidates with optimum pharmacoki
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JAX Guide: Assessing Antibody Pharmacokinetics Using the JAX FcRn Platform
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Poster: Choosing the Appropriate Immune System- Humanized Mouse Model for Immuno-Modulatory Therapies
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Human Immune System Engrafted Mice and Their Role in Human Antibody-Based Drug Development
Brian Soper, Ph.D., Senior Manager, Technical Information Services, The Jackson Laboratory speaks about human immune system engrafted mice and their role in human antibody-based drug development.
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Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors
Johannes Sam, Roche Title: Studying the Mode of Action of TCell Bispecific Antibodies and their Combinations with Checkpoint Inhibitors and Immunomodulators in Humanized Mice
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Testing the Efficacy of Immuno-Modulatory Antibodies in Humanized Mice
Aaron Rose, Ph.D., Senior Study Director, In Vivo Services, The Jackson Laboratory speaks about testing the efficacy of immunomodulatory antibodies in humanized mice.
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The ABC’s of CAR T Cell Therapies
All that glitters… Cancer cells have found ingenious ways to evade the body’s immune system. These cells can shut off cytotoxic activity of anti-tumor...
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