2022 SfN Poster: TGN1412-Induced Cytokine Release Syndrome and Pathological Evaluation in a Humanized PBMC Mouse Model

A poster presented at the Society of Toxicology Annual Meeting and Expo in 2022. The PBMC humanized mouse model for CRS assessment may be a valuable tool for preclinical assessment of CRS adverse events of experimental human therapeutic antibodies including TGN1412. The poster describes the novel humanized mouse model established for testing CRS that is rapid, sensitive, and reproducible. A novel humanized mouse model has been established for testing CRS that is rapid, sensitive and reproducibleA novel humanized mouse model has been established for testing CRS that is rapid, sensitive and reproducible