The Jackson Laboratory
Bispecifics and CAR-T sequences
Human cord blood-derived hematopoietic CD34+ stem cells. Validated: greater than 25% human CD45+ cells in peripheral blood. Humanized NSG variants (hu-CD34+).
Infectious disease, gene therapy, cancer,
Assessing efficacy and toxicity in CAR-T studies in an accessible translational model. The Jackson Laboratory's in vivo PBMC-humanized mouse platform provides a wider window to look at cytokine releas
The FcRn platform from The Jackson Laboratory mimics specific aspects of the human IgG physiology providing the ideal model platform to assess the pharmacokinetics (PK) of therapeutic antibody candida
Introductory animation for the Jackson Laboratory's Humanized Mice Journal Club series. Profiling infectious disease, target validation, immunotherapies and gene therapy.
A really important component of IgG antibodies is their ability to have a really long half-life in circulation, as opposed to other Ig subclasses.
Lower pH causes the IgG antibodies, not the IgM or I
Immunomodulatory therapies are the latest weapon to be added to the cancer-fighting arsenal. These therapies work by generating or augmenting the immune response to a tumor. Discovering and validating
With The Jackson Laboratory’s novel humanized mouse models for CRS, you can test for both, immunotoxicity, and drug efficacy at the same time.
You can test candidate therapies, with or without the pre
What is Cytokine Release Syndrome? CRS occurs when the innate and adaptive immune systems are overactivated, releasing too many cytokines, which are substances that can affect other cells.