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De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)

Understanding the pharmacokinetics (PK) of lead compounds is crucial when selecting the best drug candidate for clinical development. The humanized FcRn platform is an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules, providing an accessible and efficient alternative to non-human primates. By utilizing JAX humanized FcRn models, researchers can obtain valuable data to guide the lead optimization process and minimize the risks associated with candidate selection. Join this webinar to learn more about this invaluable tool and how it can benefit your research. During this presentation, we discuss:

  • The biology of FcRn and its impact on immunoglobulin and albumin half-life
  • The advantages of using a humanized FcRn platform for immunoglobulin-based therapeutic lead selection
  • Selecting and using specific variants of humanized FcRn models for drug evaluation
  • Designing a pharmacokinetic study with humanized FcRn models based on in vivo data of several therapeutics