Precision Medicine for Your Practice: Interpreting Results from Somatic Cancer Panels (CME)
Self-paced • 0.5 credits
About this Course
Precision Medicine for Your Practice is a series of short (20-30 min), online modules covering specific topics in genomics and precision medicine. In this module, Interpreting Results from Somatic Cancer Panel Testing, participants will learn how to find and use important information on somatic cancer testing panel reports. What are the key components of a test report? What do specific findings mean? Learn how to identify important test characteristics to compare and contrast offerings from different labs, find actionable information on the test report, and interpret results in the context of the individual patient using the five parts of this module: overview information via an animated video; practice cases to facilitate learning-by-doing; "dig deeper" for more in-depth topics; and logistics and additional resources for more detail.
CME Disclosures
Release Date: June 6, 2017
Renewal Date: June 4, 2020
Expiration Date: June 4, 2023
Objectives
Upon completion of this educational activity, the learner will be able to:
- Identify important test characteristics to compare and contrast offerings from different labs
- Find actionable information on the report
- Interpret results in the context of the individual patient
Statement of Need
Genetic technology is rapidly expanding, often too quickly for physicians and other health professionals to become familiar with new technologies before their patients inquire about them, and too quickly for adequate evidence regarding the clinical utility of the technologies to be produced. This educational module will assist physicians and health professionals to determine when somatic cancer panel testing is appropriate for their patients and how to interpret the results of such testing.
Statement of Competency
This activity is designed to address the following ABMS/ACGME competencies: patient care, medical knowledge, and interpersonal and communication skills.
Accreditation Statement
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Credit Designation Statement
The American Medical Association designates this enduring material for a maximum of .50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Claiming Your CME Credit
In order to claim AMA PRA Category 1 Credit™, you must: 1) answer the pre-assessment questions, 2) work through the module in its entirety, 3) successfully complete the post-assessment by answering 2 out of 3 questions correctly and 4) complete the evaluation.
Planning Committee
- Barry D. Dickinson, PhD, CME Program Committee, AMA
- Abdallah Elias, MD, Department of Medical Genetics, Shodair Children's Hospital
- Jeanette McCarthy, MPH, PhD, Visiting Associate Professor, Division of Medical Genetics, UCSF School of Medicine
- Laura Nicholson, MD, Co-Director of Education, Scripps Translational Science Institute
- James O'Leary, MBA, Chief innovation Officer, Genetic Alliance
- Janet K. Williams, PhD, RN, FAAN, Professor of Nursing, Chair of Behavioral and Social Science Research, University of Iowa
Faculty
- Barry D. Dickinson, PhD, CME Program Committee, AMA (Content Reviewer)
- Emily Edelman, MS, CGC, Associate Director, Clinical and Continuing Education, The Jackson Laboratory (Author)
- Abdallah Elias, MD, Department of Medical Genetics, Shodair Children's Hospital (Content Reviewer)
- Marilyn J. Heine, MD, Hematologist/Oncologists, Regional Hematology Oncology Associates (Content Consultant)
- Therese Ingram Nissen, MA, Senior Instructional Designer/Technologist, The Jackson Laboratory (Author)
- Katie Johansen Taber, PhD, Principal Policy Analyst, Science and Biotechnology, AMA (Author)
- Barbara L. McAneny, MD, CEO, New Mexico Oncology Hematology Consultants (Content Consultant)
- Laura Nicholson, MD, Co-Director of Education, Scripps Translational Science Institute (Author)
- James O'Leary, MBA, Chief innovation Officer, Genetic Alliance (Content Reviewer)
- Kate Reed, MPH, ScM, CGC, Director, Clinical and Continuing Education, The Jackson Laboratory (Author)
- Suzanna Schott, ScM, CGC, Medical Writer, The Jackson Laboratory (Author)
Disclosure Statement
In order to assure the highest quality of certified CME programming, and to comply with the ACCME Standards for Commercial Support, the AMA requires that all faculty, planners and members of the AMA CME Program Committee disclose relevant financial relationships with any commercial or proprietary entity producing health care goods or services relevant to the content being planned or presented. The following disclosures are provided:
- Barbara L. McAneny, MD, CEO of Innovative Oncology Business Solutions, and CEO or New Mexico Hematology Oncology Consultants Ltd
- Jeanette McCarthy, PhD, MPH, Consultant to Big Science Media, Omicia, and Precision Medicine Advisors
- Suzanna Schott, ScM, CGC, Stockholder of Merck, Amgen, and Teva
- Janet K. Williams, PhD, RN, FAAN, Stockholder of Pfizer
No other planners or faculty have relevant financial relationships to disclose.
References
Bardia A et al. Metastatic Breast Cancer With ESR1 Mutation: Clinical Management Considerations From the Molecular and Precision Medicine (MAP) Tumor Board at Massachusetts General Hospital. The Oncologist. 2016;21:1035–1040.
Gray PN et al. Not All Next Generation Sequencing Diagnostics are Created Equal: Understanding the Nuances of Solid Tumor Assay Design for Somatic Mutation Detection. Cancers (Basel). 2015. 7(3): 1313–1332.
Hegde M et al. Reporting incidental findings in genomic scale clinical sequencing: a clinical laboratory perspective: a report of the Association for Molecular Pathology. J Mol Diagn. 2015. 17: 107–117
Hofstatter EW, Bale AE. The Promise and Pitfalls of Genomics-Driven Cancer Medicine. American Medical Association Journal of Ethics. 2013. 15(8): 681-686.
Jones S et al. Personalized genomic analyses for cancer mutation discovery and interpretation. Sci Transl Med. 2015. 7(283):283ra53.
Kalia SS et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med. 2017. 19(2):249-255.
Le Tourneau C et al. Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials. JNCI. 2016. 108(4).
Li MM et al. Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer. Journal of Molecular Diagnostics. 2017. 19(1):4-23.
National Comprehensive Care Network Guidelines. Colon Cancer. Version 1.2017. 11/23/16.
Raymond VM et al. Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories. JNCI. 2016. 108 (4)
Schrader KA et al. Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA. JAMA Oncol. 2016 Jan;2(1):104-11.
Sholl LM et al. Institutional implementation of clinical tumor profiling on an unselected cancer population. JCI Insight. 2016. 1(19):e87062.
Tafe LJ et al. Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center. The Oncologist. 2015. 20:1011
Hardware/software Requirements
Audio speakers or headphones
Screen resolution of 800X600 or higher
Adobe Reader 5.0 or higher
As of June 4, 2016, we support the following versions of Flash and popular web browsers:
- Internet Explorer 11 and Edge
- Chrome 50 and 51
- Safari 8 and 9
- Firefox 45 and 46 (Extended Releases (Links to an external site.) are not supported)
- Flash 20 and 21 (used for recording or viewing audio/video and uploading files)
- Respondus Lockdown Browser (supporting the latest system requirements (Links to an external site.))
Operating Systems
- Windows 7 and newer
- Mac OSX 10.6 and newer
- Linux - chromeOS
Mobile Operating System Native App Support
- iOS 7 and newer
- Android 4.2 and newer
Should you have questions regarding the content of the activity or if you need technical support, please email Clinical and Continuing Education at the Jackson Laboratory.