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JAX Humanized Mice PubCast: CD19-CD28 Bispecific + FcRn mouse model to predict human PK

In this PubCast, we delve into Roche’s integration of humanized mice in their preclinical drug development pipeline to assess the safety and efficacy of their CD19-CD28 bispecific. We focus on their use of FcRn mice to reliably predict human PK to calculate a safe starting dose for their ongoing Phase 1 clinical trial.

Original Publication
HuPK: FcRn Field Guide