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Humanized Mice
Case Study: Evaluation of Bispecific Antibody Efficacy and Drug-Induced Cytokine Release

Case Study: Evaluation of Bispecific Antibody Efficacy and Drug-Induced Cytokine Release

Published Date October 6, 2020

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CRS Evaluation Studies: An Overview
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Data Set - Bispecific Antibody Efficacy and CRS

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JAX Humanized Mice PubCast: HIV-1 in Humanized Mice (Mar. 14, 2024)

In this PubCast, we discuss a study from Yale University that employed humanized PBMC-NSG mice to model HIV and test the efficacy of two novel long-acting antiretroviral delivery systems. Resource

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Translatable Efficacy & Safety Testing of mAb, Bispecific, & CAR T Therapies

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De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)

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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages

In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.

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Rapid In Vivo Evaluation of Immuno-Modulatory Therapies Using Hu-PBMC NSG™ Mice

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over 1 year ago
Leveraging Gene Therapy to Achieve Long-Term Continuous or Controllable Expression of Biotherapeutics

Leading this presentation is guest speaker Dr. Timothy Cripe from Nationwide Children’s Hospital and The Ohio State University.

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over 1 year ago
DROSHA but not DICER is Required for Human Haematopoietic Stem Cell Function

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almost 2 years ago
Novel Humanized Mouse Model for Assessment of Human Allogeneic Responses in Organ Transplantation

Ashwin Ajith Ph.D., a postdoctoral fellow at the Georgia Cancer Center, Augusta University, discusses using humanized mouse models to study alloimmune responsiveness between donor and recipients.

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almost 2 years ago
Modeling Human Melanoma To Understand And Treat Resistance To Immunotherapy

Meenard Herlyn, DVM, DSc discusses the development of a variety of 3D models, from human skin equivalents to organoids, mimicking cellular interactions in normal and malignant tissues.

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almost 2 years ago
Immune-Humanized PDX Model-Estrogen-Independent, Hormone Receptor-Positive Metastatic Breast Cancer

The most common type of breast cancer is estrogen receptor-positive (ER+). ER+ tumors can be successfully treated with hormone therapy, but many tumors acquire endocrine resistance which limits treatm

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almost 2 years ago
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This discussion focuses on preclinical efficacy and safety testing for novel antibody-based therapeutics.

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about 2 years ago
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CRISPR/Cas9 can quickly generate new translational mouse models directly on the genetic background needed for your preclinical research. This saves valuable research time by reducing the need for...

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about 2 years ago
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Hong Zheng, M.D., Ph.D., Associate Professor of Medicine at Penn State Cancer Institute, Penn State University College of Medicine joined us to lead a discussion on a new immune-humanized mouse model.

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about 2 years ago
Achieving Relevant Preclinical Characterization of CAR T Cell Therapies

This whitepaper examines the constraints and challenges inherent in each CAR T study type and how to overcome them with in vivo studies using fully humanized mouse models.

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Review JAX’s CRS evaluation capabilities and see how a CRS study can help move your CAR T therapeutic into the clinic faster, safer, and more confidently.

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