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Advancing Translational Relevance in Preclinical Mouse Models for Alzheimer’s Disease

Published Date

Alzheimer’s disease (AD) is a genetically complex neurodegenerative disorder that poses significant challenges for the development and validation of predictive mouse models for preclinical research. In this presentation, we will address the following topics:

  • Evaluation of widely used traditional AD mouse models, such as 5xFAD and 3xTg, which represent familial AD conditions accounting for less than five percent of Alzheimer’s disease cases
  • Discussion of the scientific rationale for the development of next-generation models through the MODEL AD consortium, including late-onset Alzheimer’s disease (LOAD) models designed to better capture the genetic risk architecture and disease heterogeneity associated with sporadic AD
  • Guidance on the informed selection of in vivo mouse models for the preclinical evaluation of therapeutic candidates for Alzheimer’s disease