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S15-DKO: New Platform for Engraftment of Human PBMC Supporting Multilineage Immune Cells, Low GvHD

Published Date

Join us to review the engraftment profiles of multiple human PBMC donors in blood and tissues of the new S15-DKO recipient strain as well as data demonstrating memory B cell immune responses and NK cell functionality.

In this webinar, we explore:-

  • Creation of the S15-DKO strain (NSG-NSG-MHC I/II DKO × NSG-SGM3-IL15), which supports broader human immune cell engraftment (T, B/plasma, NK, cDC, macrophages, γδ T cells) without acute xGvHD
  • Human PBMC donor specific engraftment profiles of immune cells over time in blood, spleen, lung, liver and bone marrow
  • Data demonstrating memory B cell immune responses and NK cell functionality