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Immuno-Oncology/Oncology
Immunomodulatory Profile

Immunomodulatory Profile

Published Date August 28, 2023

Bispecifics and CAR-T sequences

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Previous Flipbook

2023 AALAS P402 Evaluating sub-renal capsule cavity tumor growth in immunodeficient NSG-MHC I/II double knock-out mice
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Of Mice and Men - FcRn Biology and it's Implications in a Therapeutic Perspective

Other content in this Stream

11 months ago
Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models

Peripheral blood mononuclear cell (PBMC)-engrafted NSG mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention.

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6 months ago
Enhanced Development of Human Innate Immunity in Humanized Mice

Learn about JAX's enhanced innate immune models: the CD34+ engrafted NSG-FLT3 and NSG-FLT3-IL15 mice, presented by Michael Brehm, Ph.D., UMass Medical School.

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about 1 year ago
Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research

During this webinar, we will discuss the most widely used immunodeficient mouse models and important considerations for selecting the most appropriate model.

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6 months ago
JAX Humanized Mice PubCast: Acute Myeloid Leukemia + NSG-MHC I/II DKO Mice

In this episode, we delve into a publication that established a novel humanized mouse model of graft-versus-leukemia that better recapitulates the characteristics of AML relapse seen in patients.

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6 months ago
Comparing Immune-Humanized Mouse Platforms for Preclinical Applications

During this presentation, we will compare strategies for immune humanization of NSG variants to support translatable preclinical immunology, and oncology research. researchers a powerful tool for cha

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6 months ago
NSG-FLT3-IL15: A More Comprehensive Immune Humanized Model for Natural Killer Cells

In this presentation, we introduce The Jackson Laboratory’s most comprehensive immune humanized mouse platform to date: NSG- FLT3-IL15.

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over 2 years ago
Cancer immunotherapy: getting a little help from ourselves

We review strategies and mouse models used to develop highly promising therapeutic treatments using the body’s own immune system in the fight against cancer.

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over 2 years ago
SITC 2023 Comparison of Blinatumomab and Biosimilar CD19xCD3 BiTE responses in PBMC-Humanized Mice Used as a Preclinical Lymphoma Mouse Mode

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6 months ago
De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms (Oct. 24, 2023)

In this webinar, we discuss the humanized FcRn platform, an effective tool that provides relevant PK data for candidate therapeutic antibodies and albumin-conjugated molecules.

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about 1 year ago
New Immune-humanized Models Support More Diverse Human Immune Cell Lineages

In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3.

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almost 3 years ago
PEGS EU 2023 - Predicting the Clinical PK of Candidate Therapeutic Antibodies

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almost 3 years ago
2023 AALAS P403 Comparing tumor erosion rate following P16MC38 subcutaneous (SC) vs. mammary fat pad (MFP) injections

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almost 3 years ago
2023 AALAS P402 Evaluating sub-renal capsule cavity tumor growth in immunodeficient NSG-MHC I/II double knock-out mice

Read More
about 3 years ago
Of Mice and Men - FcRn Biology and it's Implications in a Therapeutic Perspective

Read More
about 3 years ago
The Next Generation of Humanized Mice for Translational Research - Dr. Michael Brehm

Read More
about 1 year ago
Humanized Mice: FcRn Biology

Simone Mester, PhD, Authera Biotech, speaking at The Jackson Laboratory EU Symposium. Of Mice and Men - FcRn biology and its implications in a therapeutic perspective.

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about 1 year ago
Humanized Mice: Hematopoietic Stem Cells and Antibody-Mediated Depletion

Frank Lehmann, PhD, Cimeio Therapeutics, speaking at The Jackson Laboratory EU Symposium. Molecular shielding protects hematopoietic stem cells from antibody-mediated depletion.

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about 1 year ago
Humanized Mice: Next Generation Mesenchymal Cell Therapy: From CAR-T to COVID-19

Tomer Bronshtein, PhD speaking at The Jackson Laboratory EU Symposium. Preclinical to clinical development of next-generation mesenchymal cell therapy: from CAR-T induced CRS in humanized models to re

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about 3 years ago
CRS Highlights for EU Symposium

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about 3 years ago
Using the Hu-PK Platform to Predict the PK of Candidate Therapeutic Antibodies

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