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New Immune-humanized Models Support More Diverse Human Immune Cell Lineages

Published Date

Humanized NOD scid gamma (NSG™) mice are an invaluable tool in the field of immuno-oncology. In this webinar, we will introduce two new enhanced NSG models developed at The Jackson Laboratory: NSG-SGM3-IL15 and NSG-FLT3. When engrafted with CD34+ hematopoietic stem cells, these new models support the development of more diverse human immune cell lineages. These new breakthrough platforms surpass the capabilities of other humanized strains for recapitulating the human immune system. We invite you to join this presentation as we discuss:

  • Advantages of using CD34 humanized NSG-SGM3-IL15 and NSG-FLT3 mouse strains in immuno-oncology research
  • Data demonstrating NSG-SGM3-IL15 mice support the development of multilineage human immune cell populations following CD34+ engraftment, particularly myeloid and mature natural killer cells
  • Data showing NSG-FLT3 mice support the development of human myeloid cell populations following CD34+ engraftment, with special emphasis on dendritic cells • Sample tumor growth kinetics in NSG-SGM3-IL15 and NSG-FLT3