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Designing Smarter ALS Studies: Best Practices with JAX Mouse Models

Published Date

ALS research warrants careful study design and planning to ensure your studies are set up for success. In this webinar, you will learn best practices for study design using JAX ALS models to support your ALS research.

The TIS team will cover:

  • Guidance on the informed selection of relevant in vivo mouse models for ALS
  • Discussion of the scientific rationale for key study design elements — including model selection (e.g., SOD1, TDP-43, C9orf72 models), endpoint and biomarker selection, timing of dosing relative to disease onset, and incorporation of the Envision™ platform
  • Common pitfalls in preclinical ALS study execution including copy number variation affecting phenotypes, the impact of the genetic background on the expression of the phenotypes, and managing terminal tissue collection in strains with short survival