The Consequences of Sex Bias in Preclinical Research
In mouse-based preclinical research, researchers often favor selection of one sex over the other for their studies. While sex-based model selection may sometimes have scientific justification, overlooking sex as a biological variable has several consequences. Single- sex studies can lead to skewed research, translatability issues, or flawed conclusions, and raise concerns regarding ethical practices and the 3Rs.
During this presentation, you will learn more about:
- Scientific rationale for sex-specific mouse selection
- The scientific impact of sex bias on multiple biological disciplines
- The significant effects of sex bias on animal welfare
- 3Rs guidelines and recommendations for eliminating sex bias in preclinical studies