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Advancing Immunotherapy Research with PBMC-Engrafted NSG* Models

Published Date

Are you looking for a translationally relevant preclinical platform to evaluate human T cell immunomodulatory therapies? Peripheral blood mononuclear cell (PBMC)-engrafted NSG* mice serve as a robust model for studying T cell activation, immune modulation, and therapeutic intervention. These models play a critical role in research on graft-versus-host disease (GvHD), immuno-oncology, and much more.

In this webinar, we will explore:

  • The importance of immunotherapies in disease treatment
  • Key differences between PBMC and CD34+ stem cell engraftment
  • Comparison of NSG and NSG-MHC I/II DKO models for studying immune responses
  • Applications beyond immuno-oncology: Utility of PBMC-engrafted models in autoimmune and infectious disease research

*NOTE: NSG is a registered trademark in the USA and other countries.